A5101654769- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Insect-Plant Interactions and Control
- Chronic Lymphocytic Leukemia Research
- Mechanical Circulatory Support Devices
- Chronic Myeloid Leukemia Treatments
- Cardiac electrophysiology and arrhythmias
- Sphingolipid Metabolism and Signaling
- Cancer-related gene regulation
- Cytomegalovirus and herpesvirus research
- Plant and animal studies
- Angiogenesis and VEGF in Cancer
- Plant Parasitism and Resistance
- Intravenous Infusion Technology and Safety
- Liver Disease Diagnosis and Treatment
- Medicinal plant effects and applications
- Ubiquitin and proteasome pathways
- Glioma Diagnosis and Treatment
- Signaling Pathways in Disease
- Renal and related cancers
Qingdao University
2017-2024
Affiliated Hospital of Qingdao University
2017-2024
Medtronic (United States)
2013-2024
Army Medical University
1997-2023
Southwest Hospital
2018-2023
Chongqing Medical University
2023
Zhejiang University
2016-2021
WuXi AppTec (China)
2020
University of Oxford
2019
Hospital Universitario de San Vicente Fundación
2019
Abstract Despite optimal medical management (OMM), low back pain (LBP) can be disabling, particularly after spinal surgery. Spinal cord stimulation (SCS) is effective in reducing neuropathic leg pain; however, evidence limited for LBP. This prospective, open-label, parallel-group trial randomized (1:1) failed surgery syndrome (FBSS) patients with predominant LBP to SCS plus OMM (SCS group) or alone (OMM at 28 sites Europe and the Americas. If was successful, a multicolumn system implanted....
Dysregulation of tumor-relevant proteins may contribute to human hepatocellular carcinoma (HCC) tumorigenesis. FBXO45 is an E3 ubiquitin ligase that frequently elevated expression in HCC. However, it remains unknown whether associated with hepatocarcinogenesis and how treat HCC patients high expression. Here, IHC qPCR analysis revealed protein mRNA were highly expressed 54.3% (57 105) 52.2% (132 253) the tissue samples, respectively. Highly promoted liver tumorigenesis transgenic mice....
IntroductionIn the PROMISE study, a multinational randomized controlled trial (RCT) of effectiveness spinal cord stimulation (SCS) with multicolumn surgical leads as treatment low back pain, clinicians followed their usual practice. An early, unplanned safety analysis revealed that infection rate in Belgium (5/23), where duration was median 21.5 days, significantly higher than 1/64 observed other study countries (median 5.8 p < 0.01). This report reviews infections after completion.Materials...
FBXW7 is a tumor suppressive E3 ligase, whereas RAS-ERK and mechanistic target of rapamycin kinase (mTORC1) are two major oncogenic pathways. Whether how regulates these pathways unknown. Here, we showed that SHOC2, RAS activator, substrate. Growth stimuli trigger SHOC2 phosphorylation on Thr507 by the mitogen-activated protein (MAPK) signal, which facilitates binding for ubiquitylation degradation. FBXW7-mediated degradation terminates RAS-MAPK signals inhibits proliferation. Furthermore,...
Mycophenolate mofetil is used increasingly to provide immunosuppression after nonmyeloablative allogeneic hematopoietic cell transplantation. There wide variability in the pharmacokinetics of mycophenolic acid (MPA), active metabolite, and low concentrations are associated with rejection organ We hypothesized that MPA was poorer engraftment a higher incidence acute graft versus host disease. evaluated 87 adult subjects undergoing nonmyeloablative-related nonmyeloablative-unrelated...
Abstract The tripartite motif (TRIM) family proteins play a great role in carcinogenesis. However, the expression pattern, prognostic value and biological functions of containing 23 (TRIM23) colorectal cancer (CRC) are poorly understood. Here, we found that TRIM23 is up‐regulated associated with tumour size, lymph node metastasis, American Joint Committee on Cancer (AJCC) stage poor prognosis CRC. Multivariate Cox regression analyses revealed overexpression could be identified as an...
Abstract Background Although results of case series support the use spinal cord stimulation in failed back surgery syndrome patients with predominant low pain, no confirmatory randomized controlled trial has been undertaken this patient group to date. PROMISE is a multicenter, prospective, randomized, open-label, parallel-group study designed compare clinical effectiveness plus optimal medical management alone and pain. Method/Design Patients will be recruited approximately 30 centers across...
Abstract Background Fucoidan, a water-soluble polysaccharide, exerts anticoagulant and antiviral functions. It was recently reported that fucoidan also an antitumor function. Lung cancer is one of the most common cancers in world. The aim this study to investigate anti-tumor,apoptosis anti-metastasis effects both cell-based assays mouse xenograft model, as well clarify possible role m-TOR pathway protection. Methods In vitro: Different concentrations were given act on non-small cell lung...
Abstract Background Radiation therapy is the cornerstone of treatment for adult-type diffuse gliomas, but recurrences are inevitable. Our study assessed prognosis and recurrence pattern different radiotherapy volumes after temozolomide-based chemoradiation in our institution. Methods The plans were classified into two groups, plan 1 intentionally involved entire edema area while 2 did not. Retrospectively investigate differences outcomes 118 gliomas patients between these plans. Then, who...
<h3>Background and Objectives</h3> We evaluated the infusion accuracy device-related safety of implantable drug pumps in subjects with chronic pain or severe spasticity. <h3>Methods</h3> Nine centers United States enrolled patients receiving intrathecal delivery systems to manage and/or Infusion was assessed at 6 12 months by comparing syringe-measured delivered volumes programmer-predicted volumes. Safety through analysis adverse events. Separate laboratory testing conducted manufacturer...
In this study, we aim to evaluate the prognostic role of serum uric acid and gamma-glutamyltransferase in advanced gastric cancer patients.A total 180 patients pathologically diagnosed with were included retrospective study. We used time-dependent receiver operating characteristic (ROC) curves identify optimal cut-off value (UA) (GGT). Survival analysis was performed using Kaplan-Meier method log-rank test, multivariate Cox regression analyses applied. A nomogram formulated, calibration...
In our previous study, cardiac glycosides including bufalin, a group of sodium pump (Na+/K+-ATPase) inhibitors widely used to treat heart failure for many years, have been demonstrated induce delay mitotic entry and arrest in cancer cells. However, the underlying mechanism remains poorly understood. Here, we reported first time that glycoside bufalin induced prometaphase by inhibition activation Aurora A/B. Furthermore, prevented A recruitment centrosomes B unattached kinetochores....
In plants, sphingolipids, such as long-chain bases (LCBs), act bioactive molecules in stress responses. Until now, it is still not clear if these lipids are involved biotic responses to herbivore. Herein we report that a rice LCB gene, OsLCB2a1 encoding subunit of serine palmitoyltransferase (SPT), key enzyme responsible for the de novo biosynthesis plays critical role plant defense response brown planthopper (BPH) attack and its up-regulation protects plants from herbivore infestation....
Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumour suppression, but whether its downregulation cancers is associated with posttranslational regulation remains unclear. Here, we observed that HLTF was significantly downregulated hepatocellular carcinoma (HCC) tissues positively survival HCC patients. Mechanistically, decreased expression attributed elevated β-TrCP-mediated ubiquitination degradation. Knockdown enhanced p62...
Background Head and neck cancers are a heterogeneous, aggressive, genetically complex collection of malignancies the oral cavity, nasopharynx, oropharynx, hypopharynx, larynx, paranasal sinuses salivary glands, which difficult to treat. Regional lymph nodes metastasis is significant poor prognosis factor for head squamous cell carcinoma. Metastasis regional reduces 5-year survival rate by 50% compared with that patients early-stage disease. Accurate evaluation cervical node vital component...
Lung squamous cell carcinoma (LUSC) represents 30% of all non-small lung carcinoma. Targeted therapy is not sufficient for LUSC patients because the low frequency targeted-effective mutation in whereas immunotherapy offers more options with LUSC. We explored a ferroptosis-related prognostic signature that can potentially assess prognosis and efficacy patients. A total 502 were downloaded from The Cancer Genome Atlas (TCGA). external validation data obtained Gene Expression Omnibus (GEO):...
Insecticide overuse in crop production systems often results detrimental effects on predators and parasitoids, which regulate important insect pests. The natural enemies are also unable to survive monocrop landscapes with the absence of shelter or food sources. Diversified vegetation, especially flowering plants, can enhance enemy abundance diversity, thus strengthening biological control, enabling farmers reduce insecticides. In this study, we conserved bund vegetation manipulated existing...
Aberrantly low expression of NF-κB inhibitor α (IκBα) is observed in hepatocellular carcinoma (HCC), yet the underlying mechanism via which IκBα regulates HCC remains largely unknown. Therefore, to determine potential function hepatocarcinogenesis, present study used immunohistochemistry (IHC) staining analyze associations between protein and clinicopathologic characteristics 107 patients with HCC. It was found that significantly associated tumor recurrence. Moreover, decreased tissue...