A5100668765- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Sphingolipid Metabolism and Signaling
- MicroRNA in disease regulation
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Cholesterol and Lipid Metabolism
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- RNA Research and Splicing
- Cerebrovascular and Carotid Artery Diseases
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Genomics and Diagnostics
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Histone Deacetylase Inhibitors Research
Soochow University
2012-2025
Guiyang Medical University
2019-2025
Xuzhou Central Hospital
2022-2024
Xinqiao Hospital
2012-2024
Army Medical University
2014-2024
Hebei General Hospital
2024
Huazhong Agricultural University
2024
First Affiliated Hospital of Soochow University
2023
Chongqing Medical University
2018-2023
Second Affiliated Hospital of Chongqing Medical University
2018-2023
Metabolic reprogramming is critical for the polarization and function of tumor-associated macrophages (TAM) hepatocarcinogenesis, but how this occurs unknown. Here, we showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, downregulated hepatocellular carcinoma (HCC)-associated macrophages, which correlated with tumorigenesis enhanced accumulation M2 TAMs. Mechanistically, RIPK3 deficiency TAMs reduced reactive oxygen species significantly inhibited...
Although the prognostic outcomes of liver cancer (LC) cases have improved with advancement in diagnostic technology and treatment methods, transferability recurrence HCC 5-year 10-year survival rates patients remained unsatisfactory. As a result, there is need for more accurate indicators that can detect early, effectively improving prognosis patients. Whole-genome sequencing (WGS) revealed circ-ZEB1 PIK3CA are highly expressed tissues, whereas miR-199a-3p significantly downregulated HCC....
The presence of circulating tumor cells (CTCs) in peripheral blood is associated with metastasis and prognosis hepatocellular carcinoma (HCC) patients. epithelial–mesenchymal transition (EMT) has a pivotal role invasion dissemination. To identify more sensitive biomarkers for evaluating prognosis, we investigated the expression EMT markers, including vimentin, twist, ZEB1, ZEB2, snail, slug E-cadherin CTCs, primary HCC tumors adjacent non-tumoral liver tissues. After isolating viable CTCs...
Cancer stem cells (CSCs) are responsible for cancer formation, recurrence and drug resistance. c-Myc, one of the core markers cells, has recently been considered to serve as a link between malignancy 'stemness'. However, precise function c-Myc in colon CSCs is still unclear. In present study, subpopulation expressing CD133 surface phenotype was isolated from human HT-29 cell line, which possess greater tumor sphere-forming efficiency have higher expression 'stemness'-associated genes...
Abstract Receptor-interacting protein kinase 3 (RIPK3) is essential for mucosal repair in inflammatory bowel diseases (IBD) and colorectal cancer. However, its role tumor immunity unknown. Here, we report that decreased RIPK3 cancer correlates with the accumulation of myeloid-derived suppressor cells (MDSC). Deficiency boosted tumorigenesis via immunosuppressive activity MDSCs. Reduction MDSC elicited NFκB-transcribed COX-2, which catalyzed synthesis prostaglandin E2 (PGE2). PGE2 exacerbated...
AIMTo investigate whether fecal microbiota transplantation (FMT) prevents hepatic encephalopathy (HE) in rats with carbon tetrachloride (CCl4)-induced acute dysfunction. METHODSA rat model of HE was established CCl4.Rat behaviors and spatial learning capability were observed, necrosis, intestinal mucosal barrier, serum ammonia levels permeability determined receiving FMT treatment.Furthermore, the expression tight junction proteins (Claudin-1, Claudin-6 Occludin), Toll-like receptor (TLR)...
The mechanism underlying HCC metastasis remains unclear, many oncogenes are known to regulate this process. However, the role of alternative splicing (AS) in pro-metastatic is poorly understood.By performing RNA sequencing on nine pairs primary tissues with extrahepatic (EHMH) and metastasis-free (MFH) tissues, we depicted AS landscape found a higher frequency events EHMH compared MFH. Moreover, 28 differentially expressed regulators were identified Among these, DEAD-box helicase 17 (DDX17)...
Rationale:Recent studies indicate that microglial activation and the resulting inflammatory response could be potential targets of adjuvant therapy for ischemic stroke.Many have emphasized a well-established function Annexin-A1 (ANXA1) in immune system, including regulation activation.Nevertheless, few therapeutic interventions targeting ANXA1 microglia stroke been conducted.In present study, Tat-NTS, small peptide developed to prevent from entering nucleus, was utilized.We discovered...
Abstract Background A growing body of evidence suggests that microRNAs (miRNAs) play an important role in cancer diagnosis and therapy. MicroRNA-99a (miR-99a), a potential tumor suppressor, is downregulated several human malignancies. The expression function miR-99a, however, have not been investigated renal cell carcinoma (RCC) so far. We therefore examined the miR-99a RCC lines tissues, assessed impact on tumorigenesis RCC. Methods MiR-99a levels 40 pairs matched adjacent non-tumor tissues...
Parkinson's disease (PD) is characterized by the selective degeneration of neuronal populations presumably due to pathogenic interactions between aging and predisposing factors such as increased levels α-synuclein. Here, we genetically modulate activity transcription factor Forkhead box protein O3 (FOXO3) in adult nigral dopaminergic neurons using viral vectors explore how this determinant longevity impacts on fate normal diseased conditions. We find that are particularly vulnerable changes...
SIRT1 is a multifaceted NAD+-dependent protein deacetylase known to act as tumor promoter or suppressor in different cancers. Here, we describe novel mechanism of SIRT1-induced hepatocellular carcinoma (HCC) metastasis. overexpression was frequently detected human HCC specimens and associated with microvascular invasion (P = 0.0039), advanced node metastasis (TNM) stages 0.0016), recurrence 0.021) poor outcomes 0.039). Lentivirus-mediated knockdown MHCC97H cells reduced vitro vivo. depletion...
Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1α, a master regulator mitochondrial biogenesis cellular antioxidant defense, has emerged as possible therapeutic target for Parkinson’s disease, with important roles function survival dopaminergic neurons substantia nigra. The objective this study is to determine if loss PGC-1α activity contributes α-synuclein-induced degeneration. We explore vulnerability...
Background: Cancer cells undergoing invasion and metastasis possess a phenotype with attenuated glycolysis, but enhanced fatty acid oxidation (FAO). Calcium (Ca2+)-mediated signaling pathways are implicated in tumor metabolism regulation. Stromal-interaction molecule 1 (STIM1) triggered store-operated Ca2+ entry (SOCE) is the major route of influx for non-excitable including hepatocellular carcinoma (HCC) cells. However, whether how STIM1 regulates HCC via metabolic reprogramming unclear....
To understand the cause of Parkinson's disease (PD), it is important to determine functional interactions between factors linked disease. Parkin associated with autosomal recessive early-onset PD, and controls transcription PGC-1α, a master regulator mitochondrial biogenesis. These two functionally interact regulate turnover quality mitochondria, by increasing both mitophagic activity mitochondria In cortical neurons, co-expressing PGC-1α increases number enhances maximal respiration,...
Despite the FDA approval of mTOR inhibitors (mTORi) for treatment renal cell carcinoma (RCC), benefits are relatively modest and few responders usually develop resistance. We investigated whether resistance to mTORi is due upregulation PD-L1 underlying molecular mechanism.The effects transcription factor EB (TFEB) on RCC proliferation, apoptosis, migration were evaluated. Correlation TFEB with expression, as well inhibition was assessed in human primary clear RCCs. The regulation by...
microRNA-122 (miR-122) is the most abundant and specific miRNA in liver. It acts as an important tumor suppressor hepatocellular carcinoma (HCC) through regulating its target genes, but details of own regulation are largely unknown. Farnesoid X receptor (FXR), a transcription factor with multiple functions, plays role protecting against liver carcinogenesis, it unclear whether anti-HCC effect FXR involved miR-122. The levels miR-122 HCC tissues cell lines were examined by quantitative...
Abstract Background Hepatocellular carcinoma (HCC) is associated with a dismal prognosis, and prediction of the prognosis HCC can assist in therapeutic decision-makings. An increasing number studies have shown that texture parameters images reflect heterogeneity tumors, may potential to predict patients after surgical resection. The aim this study was investigate prognostic value computed tomography (CT) hepatectomy develop radiomics nomogram by combining clinicopathological factors...
Type 2 diabetes (T2D) is one of the most escalating global metabolic diseases, which highly associated with insulin resistance (IR) and risk combination nonalcoholic fatty liver disease (NAFLD). Previous studies suggest that soluble klotho (sKL) could serve as a circulating hormone to mediate energy metabolism, but detailed mechanism poorly understood. In this study, we generated T2D models wild-type (WT), sKL heterozygous (KL+/-), transgenic (TgKL) mice continuously fed high-fat diet (HFD)...
Background & Aims: Liver cancer stem cells (LCSCs) mediate therapeutic resistance and correlate with poor outcomes in patients hepatocellular carcinoma (HCC). Fibroblast growth factor (FGF)-19 is a crucial oncogenic driver gene HCC correlates prognosis. However, whether FGF19 signaling regulates the self-renewal of LCSCs unknown. Methods: were enriched by serum-free suspension. Self-renewal characterized sphere formation assay, clonogenicity sorafenib assay tumorigenic potential assays. Ca2+...
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder that frequently exhibits low-grade inflammation, pro-oxidant activity, and gut dysbiosis. PCOS has become one of the leading causes female infertility worldwide. Recently, omega-3 polyunsaturated fatty acids (PUFAs) have been proven to benefit metabolic disorders in patients. However, its roles regulation endocrinal balances pathophysiology are not clear. In present study, we aimed explore how PUFAs alleviate...