A5011226747- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Pomegranate: compositions and health benefits
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Parathyroid Disorders and Treatments
- Diverticular Disease and Complications
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Liver physiology and pathology
- Antioxidant Activity and Oxidative Stress
- Gastric Cancer Management and Outcomes
- Hedgehog Signaling Pathway Studies
- Esophageal and GI Pathology
- Mitochondrial Function and Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hormonal Regulation and Hypertension
- Thyroid Cancer Diagnosis and Treatment
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Epigenetics and DNA Methylation
Amazentis (Switzerland)
2021-2025
École Polytechnique Fédérale de Lausanne
2016-2025
University of Palermo
2021
Telethon Institute Of Genetics And Medicine
2019
Sapienza University of Rome
2012-2018
Swiss Integrative Center for Human Health
2016
Centre for Genomic Regulation
2013-2014
Centro de Investigación Biomédica en Red
2013
Centre for Biomedical Network Research on Rare Diseases
2013
Pompeu Fabra University
2013
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet susceptible to senescence during aging. We demonstrate the importance of amount oxidized form cellular nicotinamide adenine dinucleotide (NAD(+)) its effect on mitochondrial activity as a pivotal switch modulate muscle SC (MuSC) senescence. Treatment with NAD(+) precursor riboside (NR) induced unfolded protein response synthesis prohibitin proteins, this rejuvenated MuSCs in aged mice. NR also prevented MuSC mdx...
Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function adapt cellular metabolism stress. Using multiomics approach in mammalian cells treated with four types of stressors, we identify activating transcription factor 4 (ATF4) as the main regulator response. Surprisingly, canonical unfolded protein genes mediated by ATF5 are not activated. Instead, ATF4 expression cytoprotective genes, which reprogram through activation integrated (ISR). promotes...
The mitophagy inducer urolithin A reverts muscular dystrophies.
Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy mitigate muscle decline. We present results from randomized, placebo-controlled trial in middle-aged adults where we administer postbiotic compound Urolithin A (Mitopure), known activator, at two doses for 4 months (NCT03464500). The data show significant improvements strength (∼12%) with intake A. observe clinically meaningful on aerobic endurance (peak oxygen consumption [VO2]) and physical...
<h3>Importance</h3> Aging is associated with a decline in mitochondrial function and reduced exercise capacity. Urolithin A natural gut microbiome–derived food metabolite that has been shown to stimulate mitophagy improve muscle older animals induce gene expression humans. <h3>Objective</h3> To investigate whether oral administration of urolithin improved the 6-minute walk distance, endurance hand leg muscles, biomarkers cellular health. <h3>Design, Setting, Participants</h3> This...
Abstract Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to World Health Organization, OA affects over 500 million people and characterized by degradation of cartilage other tissues, severe pain, impaired mobility. Mitochondrial dysfunction contributes pathology. However, interventions rescue mitochondrial defects in human are not available. Urolithin A (Mitopure) a natural postbiotic compound that promotes mitophagy function...
Crigler-Najjar syndrome type 1 (CN1) is an inherited disorder characterized by the absence of hepatic uridine diphosphoglucuronate glucuronosyltransferase (UDPGT), enzyme responsible for conjugation and excretion bilirubin. We performed allogenic hepatocyte transplantation (AHT) in a child with CN1, aiming to improve bilirubin glucuronidation this condition. A 9-year-old boy CN1 was prepared plasmapheresis immunosuppression prednisolone tacrolimus. When graft made available, 7.5 × 109...
Article4 December 2014Open Access Source Data Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors Paola Infante Center Life [email protected], Istituto Italiano di Tecnologia, Rome, Italy Search more papers by this author Mattia Mori Romina Alfonsi Department of Molecular Medicine, University La Sapienza, Francesca Ghirga Dipartimento Chimica e Tecnologie del Farmaco, Federica Aiello Chemistry and Industrial Chemistry, Pisa, Sara Toscano Cinzia Ingallina Mariangela Siler...
Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and humans. Not everyone a microbiome capable of producing UA, making supplementation with an appealing strategy.This the first detailed investigation prevalence producers healthy population ability direct overcome both dietary variability. Dietary intake glass pomegranate juice (PJ) was used assess producer status (n = 100 participants)...
This prospective study analyzed the dropout probability and intention-to-treat survival rates of patients with hepatocellular carcinoma (HCC) selected treated according to our policy before liver transplantation (LT), particular attention those exceeding Milan criteria. Exclusion criteria for LT were macroscopic vascular invasion, metastases, poorly differentiated disease at percutaneous biopsy. A specific multi-modal adjuvant algorithm was used treat HCC LT. total 100 listed LT: 40 exceeded...
To understand the cause of Parkinson's disease (PD), it is important to determine functional interactions between factors linked disease. Parkin associated with autosomal recessive early-onset PD, and controls transcription PGC-1α, a master regulator mitochondrial biogenesis. These two functionally interact regulate turnover quality mitochondria, by increasing both mitophagic activity mitochondria In cortical neurons, co-expressing PGC-1α increases number enhances maximal respiration,...
Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also translation, thus imposing a low level of stress on eukaryotic cells. We demonstrate cell and germ-free mouse models that tetracyclines induce response (MSR), involving both ATF4-mediated integrative type I interferon (IFN) signaling. To overcome interferences with host microbiome, we identify tetracycline derivatives have minimal...