A5022736757- Metabolomics and Mass Spectrometry Studies
- GABA and Rice Research
- Phytochemicals and Antioxidant Activities
- Hedgehog Signaling Pathway Studies
- Spectroscopy and Chemometric Analyses
- Essential Oils and Antimicrobial Activity
- Epigenetics and DNA Methylation
- Edible Oils Quality and Analysis
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Postharvest Quality and Shelf Life Management
- Advanced Chemical Sensor Technologies
- Cancer-related Molecular Pathways
- Antioxidant Activity and Oxidative Stress
- Natural product bioactivities and synthesis
- NMR spectroscopy and applications
- Identification and Quantification in Food
- Cholesterol and Lipid Metabolism
- Oral and Maxillofacial Pathology
- Cynara cardunculus studies
- Nanoparticle-Based Drug Delivery
- Plant Growth Enhancement Techniques
- Meat and Animal Product Quality
- Characterization and Applications of Magnetic Nanoparticles
- Synthesis of heterocyclic compounds
Sapienza University of Rome
2016-2025
Italian Institute of Technology
2013-2017
King's College London
2017
Istituto Superiore di Sanità
2015
Article4 December 2014Open Access Source Data Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors Paola Infante Center Life [email protected], Istituto Italiano di Tecnologia, Rome, Italy Search more papers by this author Mattia Mori Romina Alfonsi Department of Molecular Medicine, University La Sapienza, Francesca Ghirga Dipartimento Chimica e Tecnologie del Farmaco, Federica Aiello Chemistry and Industrial Chemistry, Pisa, Sara Toscano Cinzia Ingallina Mariangela Siler...
Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach explore chemically biologically both essential oil aromatic water this plant. We reported chemical composition terms cannabinoid content, volatile component, phenolic flavonoid pattern, color characteristics. Then, demonstrated ethnopharmacological relevance plant cultivated Italy as source antioxidant compounds toward large panel enzymes (pancreatic lipase,...
The chemical composition of the inflorescences from four Cannabis sativa L. monoecious cultivars (Ferimon, Uso-31, Felina 32 and Fedora 17), recently introduced in Lazio Region, was monitored over season June to September giving indications on their sensorial, pharmaceutical/nutraceutical proprieties. Both untargeted (NMR) targeted (GC/MS, UHPLC, HPLC-PDA/FD spectrophotometry) analyses were carried out identify quantify compounds different classes (sugars, organic acids, amino cannabinoids,...
The recovery of bioactive compounds from crop byproducts leads to a new perspective way waste reutilization as part the circular economy. present study aimed at an exhaustive metabolite profile characterization globe artichoke and cauliflower (leaves, stalks, florets for only) prerequisite their valorization future implementations. aqueous organic extracts was analyzed using NMR-based metabolomics approach. Free amino acids, sugars, polyols, polyphenols, amines, glucosinolates, fatty...
Abstract Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range cancers. Indeed, aberrant activation Hh pathway occurring either by ligand-dependent or -independent mechanisms is key driver tumorigenesis. The smoothened (Smo) receptor one main upstream transducers signaling and validated target for development anticancer compounds, underlined FDA-approved Smo antagonist Vismodegib (GDC-0449/Erivedge) basal cell carcinoma. However, mutations that confer...
Abstract Notch signaling is considered a rational target in the therapy of several cancers, particularly those harbouring gain function mutations, including T-cell acute lymphoblastic leukemia (T-ALL). Although currently available Notch-blocking agents are showing anti-tumor activity preclinical studies, they not effective all patients and often cause severe side-effects, limiting their widespread therapeutic use. Here, by functional biological analysis most representative molecules an house...
We review the successful application of computer-aided methods to screen a unique and high-diversity <italic>in house</italic> collection library composed around 1000 individual natural products.
The chemical profile of the female inflorescence extracts from seven Cannabis sativa L. dioecious cultivars (Carmagnola, Fibranova, Eletta Campana, Antal, Tiborszallasi, Kompolti, and Tisza) was monitored at three harvesting stages (4, 14, 30 September), reaching beginning flowering to end flowering/beginning seed formation, using untargeted nuclear magnetic resonance (NMR) targeted (ultra-high-performance liquid chromatography (UHPLC) spectrophotometry) analyses. tetrahydrocannabinol...
The quality grade of an olive oil is defined according to the results analytical and organoleptic examinations.The increasing attention towards both verification methods prompted us undertake a "critical" analysis sensory data supplied by International Certificated Body (ICB), relative commercial oils produced in Mediterranean areas purchased Italy USA. ICB included chemical analyses namely free acidity, peroxide index, spectrophotometric UV evaluation, fatty acid ethyl esters stigmadiens...
Extra-virgin olive oil (383 samples; EVOOs) of three consecutive harvesting years from nine Italian regions were collected and submitted to an ¹H NMR-chemometric protocol characterize the samples according their origin (geographical area variety). A more complete assignment spectrum in CDCl₃ DMSOd₆ was reported identifying 24-methylencycolartanol. single classification model provided discrimination EVOOs among geographical macro-areas (North, Islands, Center-South), whereas a hierarchical...
Glioma is the most common and primary brain tumors in adults. Despite available multimodal therapies, glioma patients appear to have a poor prognosis. The Hedgehog (Hh) signaling involved tumorigenesis emerged as promising target for tumors. Glabrescione B (GlaB) has been recently identified first direct inhibitor of Gli1, downstream effector pathway. We established overexpression Gli1 murine cells (GL261) GlaB effect on cell viability. used 1H-nuclear magnetic resonance (NMR) metabolomic...
Anthocyanins are widespread in plants and flowers, being responsible for their different colouring. Two representative members of this family have been selected, cyanidin 3-O-β-glucopyranoside 3-O-β-galactopyranoside, probed by mass spectrometry based methods, testing performance discriminating between the two epimers. The native anthocyanins, delivered into gas phase electrospray ionization, display a comparable drift time ion mobility (IM-MS) common fragment, corresponding to loss sugar...