A5017676817- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Mass Spectrometry Techniques and Applications
- Receptor Mechanisms and Signaling
- Cancer-related Molecular Pathways
- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Analytical Methods in Pharmaceuticals
- Epigenetics and DNA Methylation
- Molecular spectroscopy and chirality
- Axial and Atropisomeric Chirality Synthesis
- Gene Regulatory Network Analysis
- Hedgehog Signaling Pathway Studies
Sapienza University of Rome
2015-2019
Delft University of Technology
2016
Glioma is the most common and primary brain tumors in adults. Despite available multimodal therapies, glioma patients appear to have a poor prognosis. The Hedgehog (Hh) signaling involved tumorigenesis emerged as promising target for tumors. Glabrescione B (GlaB) has been recently identified first direct inhibitor of Gli1, downstream effector pathway. We established overexpression Gli1 murine cells (GL261) GlaB effect on cell viability. used 1H-nuclear magnetic resonance (NMR) metabolomic...
ABSTRACT Microorganisms have developed an elaborate spectrum of mechanisms to respond and adapt environmental stress conditions. Among these is the expression dps , coding for D NA-binding p rotein from s tarved cells. Dps becomes dominant nucleoid-organizing protein in stationary-phase Escherichia coli cells required robust survival under conditions, including carbon or nitrogen starvation, oxidative stress, metal exposure, irradiation. To study complex regulation E. we utilized time-lapse...
Clobazam, a 1,5-benzodiazepin-2,4-dione, is chiral molecule because its ground state conformation features nonplanar seven-membered ring lacking reflection symmetry elements. The two conformational enantiomers of clobazam interconvert at room temperature by simple ring-flipping process. Variable HPLC on the Pirkle type (R)-N-(3,5-dinitronenzoyl)phenylglycine and (R,R)-Whelk-O1 stationary phases (CSPs) allowed us to separate for first time observe peak coalescence-decoalescence phenomena due...