A5024136818- Molecular spectroscopy and chirality
- Analytical Chemistry and Chromatography
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Properties of Aromatic Compounds
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Glycosylation and Glycoproteins Research
- Advanced NMR Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Recycling and Waste Management Techniques
- DNA and Nucleic Acid Chemistry
- Supramolecular Self-Assembly in Materials
- Photoreceptor and optogenetics research
- Microplastics and Plastic Pollution
- Neuroscience and Neuropharmacology Research
- Biopolymer Synthesis and Applications
- Analytical Methods in Pharmaceuticals
- Synthesis and Catalytic Reactions
- Polymer crystallization and properties
- Carbon dioxide utilization in catalysis
- Chromatography in Natural Products
- Chemical Reactions and Isotopes
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
Sapienza University of Rome
2012-2021
Four different hexahelicenes, 5-aza-hexahelicene (1), hexahelicene (2), 2-methyl-hexahelicene (3), and 2-bromo-hexahelicene (4), were prepared their enantiomers, which are stable at r.t., separated. Vibrational circular dichroism (VCD) spectra measured for compound 1; all the compounds, electronic (ECD) circularly polarized luminescence (CPL) recorded. Each type of experimental spectrum was compared with corresponding theoretical spectrum, determined via Density Functional Theory (DFT)....
Cationic hetero[6]helicenes 1+, 2+ and 3+ have been recently disclosed. Herein we report on their enantiomeric separation using high-performance liquid chromatography. Separation of the antipodes can be achieved in preparative scale neutral adducts with Chiralcel OD-I or Chiralpak ID CSP. Selectivity factors 1.90, 1.67, 1.96 were obtained for 1-H, 2-H, 3-H, respectively. also performed carbenium ions regular IA CSP water-containing eluents, thus allowing purity determinations aqueous...
The interconverting stereoisomers of tri-o-thymotide have been separated by HPLC on chiral stationary phases and the temperature dependence dynamic chromatographic patterns has interpreted in terms exchange between enantiomeric propeller helical conformations. Computed low energy structures CD spectra were used absolute configuration assignment.
The total synthesis of the Diels–Alder-type adducts (±)-kuwanol E and heptamethyl ether derivative (±)-kuwanon Y has been accomplished via a convergent strategy involving 2′-hydroxychalcone 6 or 9 dehydroprenylstilbene 7, in nine steps. features, as key step, Lewis acid-mediated biomimetic intermolecular Diels–Alder [4+2] cycloaddition for construction cyclohexene skeleton with three stereogenic centers. Notably, endo/exo diastereoselectivity reaction proved to be temperature-controlled.
Clobazam, a 1,5-benzodiazepin-2,4-dione, is chiral molecule because its ground state conformation features nonplanar seven-membered ring lacking reflection symmetry elements. The two conformational enantiomers of clobazam interconvert at room temperature by simple ring-flipping process. Variable HPLC on the Pirkle type (R)-N-(3,5-dinitronenzoyl)phenylglycine and (R,R)-Whelk-O1 stationary phases (CSPs) allowed us to separate for first time observe peak coalescence-decoalescence phenomena due...
Lactic acid is one of the most important compounds in field bio‐renewable chemicals. present nature but can also be produced by chemical synthesis or fermentation biomass. It used as raw material for production biodegradable and environmentally friendly polymers copolymers, such poly lactic (PLA). In this work, equilibrium distribution monomer low molecular weight oligomers aqueous solutions at different overall concentrations (from 0.09 g/g to 0.94 g/g) temperatures (423 K 453 K), was...
In this review, we reported on the Proline-chimeras characterized by resembling skeleton of Alanine (Alanine-Proline chimeras). The synthetic approaches were classified according to position methyl group pyrrolidine ring. Moreover, synthesis pyroglutamic acid derivatives will be discussed due its importance as building block and chiral pool in asymmetric numerous bioactive compounds. present review focused chemical syntheses mono-methyl substituted proline derivatives, including contribution...