A5046185021- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- Asymmetric Synthesis and Catalysis
- Molecular spectroscopy and chirality
- Axial and Atropisomeric Chirality Synthesis
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- MRI in cancer diagnosis
- GDF15 and Related Biomarkers
- Peptidase Inhibition and Analysis
- Glioma Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Aortic Disease and Treatment Approaches
- Mesenchymal stem cell research
- Radiation Dose and Imaging
- Anatomy and Medical Technology
- Protease and Inhibitor Mechanisms
- Lysosomal Storage Disorders Research
- Coordination Chemistry and Organometallics
- Aortic aneurysm repair treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Surgical Simulation and Training
Stanford University
2013-2025
Regenxbio (United States)
2024
Stanford Medicine
2022-2023
Center for Innovation
2023
Engineering Service Center und Handel (Germany)
2023
University of Basilicata
2008-2017
Lucile Packard Children's Hospital
2017
Jichi Medical University
2014
Agilent Technologies (United States)
2014
Jichi Medical University Saitama Medical Center
2014
Four different hexahelicenes, 5-aza-hexahelicene (1), hexahelicene (2), 2-methyl-hexahelicene (3), and 2-bromo-hexahelicene (4), were prepared their enantiomers, which are stable at r.t., separated. Vibrational circular dichroism (VCD) spectra measured for compound 1; all the compounds, electronic (ECD) circularly polarized luminescence (CPL) recorded. Each type of experimental spectrum was compared with corresponding theoretical spectrum, determined via Density Functional Theory (DFT)....
CD47 monoclonal antibodies (mAbs) activate tumor-associated macrophages (TAMs) in sarcomas to phagocytose and eliminate cancer cells. Though mAbs have entered clinical trials, diagnostic tests for monitoring therapy response vivo are currently lacking. Ferumoxytol is an FDA-approved iron supplement which can be used "off label" as a contrast agent: the nanoparticle-based drug phagocytosed by TAM detected with magnetic resonance imaging (MRI). We evaluated if ferumoxytol-enhanced MRI monitor...
Aim: To develop a clinically applicable MRI technique for tracking stem cells in matrix-associated stem-cell implants, using the US FDA-approved iron supplement ferumoxytol. Materials & methods: Ferumoxytol-labeling of adipose-derived (ADSCs) was optimized vitro. A total 11 rats with osteochondral defects both femurs were implanted ferumoxytol- or ferumoxides-labeled unlabeled ADSCs, and underwent up to 4 weeks post implant. The signal-to-noise ratio different implant compared t-tests...
Abstract Background ‘ Long read ’ sequencing methods have been used to identify previously uncharacterized structural variants that cause human genetic diseases. Therefore, we investigated whether long could facilitate analysis of murine models for Results The genomes six inbred strains (BTBR T + Itpr3tf/J, 129Sv1/J, C57BL/6/J, Balb/c/J, A/J, SJL/J) were analyzed using sequencing. Our results revealed (i) Structural are very abundant within the genome (4.8 per gene) and (ii) cannot...
Pathological high shear stress (HSS, 100 dyn/cm
Theranostic nanoparticles (NPs) have been designed for simultaneous therapeutic and diagnostic purposes, thereby enabling personalized cancer therapy in vivo drug tracking. However, studies thus far focused on imaging NP tumor accumulation at the macroscopic level correlating results with ex histology. Limited evidence exists whether contrast enhancement magnetic resonance (MRI) correlates microscopic level. To address this gap, purpose of our study was to correlate quantitative MRI...
To develop a clinically applicable imaging technique for monitoring differential migration of macrophages into viable and apoptotic matrix-associated stem cell implants (MASIs) in arthritic knee joints.With institutional animal care use committee approval, six athymic rats were injected with intravenous ferumoxytol (0.5 mmol iron per kilogram body weight) to preload the reticuloendothelial system oxide nanoparticles. Forty-eight hours later, all animals received MASIs adipose-derived cells...
Objective Ultra-small superparamagnetic iron oxide nanoparticles (USPIO) are promising contrast agents for magnetic resonance imaging (MRI). USPIO mediated proton relaxation rate enhancement is strongly dependent on compartmentalization of the agent and can vary depending their intracellular or extracellular location in tumor microenvironment. We compared T1- T2-enhancement pattern mouse models cancer pilot data from patients. A better understanding these MR signal effects will enable...
Purpose To determine whether endogenous labeling of macrophages with clinically applicable nanoparticles enables noninvasive detection innate immune responses to stem cell transplants magnetic resonance (MR) imaging. Materials and Methods Work human cells was approved by the institutional review board research oversight committee, animal experiments were administrative panel on laboratory care. Nine immunocompetent Sprague-Dawley rats received intravenous injection ferumoxytol, 18 Jax...
Ascending aortic dissection and rupture remain a life-threatening complication in patients with Marfan syndrome. The extracellular matrix provides strength elastic recoil to the wall, thereby preventing radial expansion. We have previously shown that ascending aneurysm formation mice (Fbn1(C1039G/+)) is associated decreased wall elastogenesis increased elastin breakdown. In this study, we test feasibility of quantifying content using MRI gadolinium-based elastin-specific magnetic resonance...
Rationale: As a cancer, Glioblastoma (GBM) is highly lethal and difficult-to-treat. With the aim of improving therapies to GBM, we developed novel target-specific theranostic nanoparticles (TNPs) that can be selectively cleaved by cathepsin B (Cat B) release potent toxin monomethyl auristatin E (MMAE). Methods: We synthesized TNPs composed ferumoxytol-based nanoparticle carrier peptide prodrug with Cat-B-responsive linker tubulin inhibitor MMAE. hypothesized intratumoral Cat cleave our MMAE...
Multiecho echo-planar imaging (EPI) was implemented for blood-oxygenation-level-dependent functional MRI at 1.5 T and compared to single-echo EPI with without parallel acceleration. A time-normalized breath-hold task using a block design protocol carried out in combination up four echo trains per excitation acceleration factors R = 1–3. Experiments were conducted five human subjects, each scanned three sessions. Across all reduction factors, both signal-to-fluctuation-noise ratio the total...
Tumor‐associated macrophages (TAM) maintain a chronic inflammation in cancers, which is associated with tumor aggressiveness and poor prognosis. The purpose of this study was to: (1) evaluate the pharmacokinetics tolerability novel ultrasmall superparamagnetic iron oxide nanoparticle (USPIO) compound GEH121333; (2) assess whether GEH121333 can serve as MR imaging biomarker for TAM; (3) compare enhancement profiles between ferumoxytol. Blood half‐lives ferumoxytol were measured by relaxometry...
Objectives Iron oxide nanoparticles have been used to track the accumulation of chimeric antigen receptor (CAR) T cells with magnetic resonance imaging (MRI). However, only nanoparticle available for clinical applications date, ferumoxytol, has caused rare but severe anaphylactic reactions. MegaPro (MegaPro-NPs) provide an improved safety profile. We evaluated whether MegaPro-NPs can be applied in vivo tracking CAR a mouse model glioblastoma multiforme. Materials and Methods labeled...
Abstract Purpose To describe approaches for determining optimal spatial and temporal resolutions the proton resonance frequency shift method of quantitative magnetic temperature imaging (MRTI) guidance transurethral ultrasonic prostate ablation. Materials Methods Temperature distributions two ultrasound applicators (90° sectored tubular planar arrays) canine ablation were measured via MRTI during in vivo sonication, agree well with two‐dimensional finite difference model simulations at...
Flexible biphenyls have been applied as efficient and practical chiroptical probes for absolute configuration assignment to chiral primary amines. The mechanism of the central-to-axial chirality transfer from amine moiety conformationally flexible biphenyl system has determined by NMR computational studies. This allowed proposing a general non-empirical rule in order establish, simply looking at sign 250 nm A band ECD spectrum derivative, torsion thus amine. method proved be very reliable...
Abstract The preparation of new chiral amino alcohols that possess a flexible biphenylazepine moiety and can work as tropos catalysts, is presented. In these compounds, the sign induced axial chirality depends on nature stereogenic centers near fragment determine stereochemical outcome in asymmetric reactions mediated by them. efficiency ligands has been explored addition arylzinc species prepared situ to aromatic aldehydes. Among them, alcohol (1 R ,2 S )‐ 4 gave best results afforded...