A5076954902- Cancer Research and Treatments
- Spine and Intervertebral Disc Pathology
- Nanoparticle-Based Drug Delivery
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Ubiquitin and proteasome pathways
- Cerebrospinal fluid and hydrocephalus
- Peptidase Inhibition and Analysis
- GDF15 and Related Biomarkers
- Cervical and Thoracic Myelopathy
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Protease and Inhibitor Mechanisms
- Anesthesia and Pain Management
- RNA Interference and Gene Delivery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Nanoplatforms for cancer theranostics
- Pain Management and Opioid Use
- Spinal Hematomas and Complications
- Pelvic and Acetabular Injuries
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Brain Metastases and Treatment
Northwestern University
2019-2024
Neurological Surgery
2018-2024
Lucile Packard Children's Hospital
2021
Stanford University
2018-2021
University Surgical Associates
2021
Palo Alto University
2021
Oxford University Press (United Kingdom)
2020
University of California San Francisco Medical Center
2018-2020
Stanford Medicine
2020
Skidmore College
2017
CD47 monoclonal antibodies (mAbs) activate tumor-associated macrophages (TAMs) in sarcomas to phagocytose and eliminate cancer cells. Though mAbs have entered clinical trials, diagnostic tests for monitoring therapy response vivo are currently lacking. Ferumoxytol is an FDA-approved iron supplement which can be used "off label" as a contrast agent: the nanoparticle-based drug phagocytosed by TAM detected with magnetic resonance imaging (MRI). We evaluated if ferumoxytol-enhanced MRI monitor...
We aim to demonstrate the safety and efficacy of utilizing 3D-printed spine models facilitate freehand pedicle screw placement in complex spinal deformity correction. Currently there is no data on using for correction.All patients undergoing correction over a 16-month period (September 2015 - December 2016) at Spine Hospital Columbia University Medical Center by senior surgeon were reviewed. used intraoperative with severe deformities. Intraoperative O-arm imaging was obtained after all...
Abstract BACKGROUND Opioid requirements in the perioperative period patients undergoing lumbar spine fusion surgery remain problematic. Although minimally invasive (MIS) techniques have been developed, there still substantial challenges to reducing length of hospital stay (LOS) because postoperative opioid requirements. OBJECTIVE To study effect implementing an enhanced recovery after (ERAS) pathway a 1-level MIS transforaminal interbody (MIS TLIF) at our institution. METHODS We implemented...
The long‐term survival of osteosarcoma patients with metastatic or recurrent disease remains dismal, and new therapeutic options are urgently needed. purpose our study was to compare the efficacy CD47 mAb plus doxorubicin combination therapy in mouse models monotherapy. Forty‐eight NOD scid gamma (NSG) mice intratibial MNNG/HOS tumors received mAb, doxorubicin, therapy, control IgG treatment. Twenty‐four ( n = 6 per group) underwent pre‐ post‐treatment magnetic resonance imaging (MRI) scans...
Background Cartilage repair outcomes of matrix-associated stem cell implants (MASIs) in patients have been highly variable. Conventional MRI cannot help distinguish between grafts that will and not the underlying cartilage defect until many months after repair. Purpose To determine if ferumoxytol nanoparticle labeling could be used to depict successful or failed MASIs compared with conventional a large-animal model. Materials Methods Between January 2016 December 2017, 10 Göttingen minipigs...
Annually, 20% of all practicing neurosurgeons in the United States are faced with medical malpractice litigation. The average indemnity paid a closed neurosurgical civil claim is $439,146, highest specialties. majority claims result from dissatisfaction following spinal surgery, although after cranial surgery tend to be costlier. On societal scale, increasing prevalence catalyst for practice defensive medicine, resulting record-level healthcare costs. Outside obvious financial strains, have...
To investigate if a deep learning convolutional neural network (CNN) could enable low-dose fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/MRI for correct treatment response assessment of children and young adults with lymphoma.In this secondary analysis prospectively collected data (ClinicalTrials.gov identifier: NCT01542879), 20 patients lymphoma (mean age, 16.4 years ± 6.4 [standard deviation]) underwent 18F-FDG between July 2015 August 2019 at baseline after induction chemotherapy....
Intraoperative stimulation has emerged as a crucial adjunct in neurosurgical oncology, aiding maximal tumor resection while preserving sensorimotor and language function. Despite increasing use clinical practice of this stimulation, there are limited data on both intraoperative seizure (IS) frequency the presence afterdischarges (ADs) patients undergoing such procedures. The objective study was to determine risk factors for IS or ADs, consequences these events.
Intraoperative stimulation is used as a crucial adjunct in neurosurgical oncology, allowing for greater extent of resection while minimizing morbidity. However, limited data exist regarding the impact cortical on frequency perioperative seizures these patients.A retrospective chart review patients undergoing awake craniotomy with electrocorticography by single surgeon at authors' institution between 2013 and 2020 was conducted. Eighty-three were identified, electrocorticography, stimulation,...
The aims of this study were to quantify inpatient healthcare costs, describe patient demographics, and analyze variables influencing costs for pediatric adult hydrocephalus shunt-related admissions in the US.
Background: Bioabsorbable meshes have seen increasing clinical use to reinforce soft tissue, and exist on a spectrum of strength loss versus absorption: several retain their for months, but remain in situ years. Others lose fully by 6 weeks. An intermediate profile, with some 3 -4 consistent absorption less than year, may be an optimal balance near-term support long-term safety. In this large animal study, we evaluate such mesh (DuraSorb, SIA), assessing its utility porcine model abdominal...
Lumbar spinal stenosis (LSS) is characterized by narrowing of the central canal, lateral recesses, or foramina leading to compression neural tissue. The clinical syndrome associated with LSS usually neurogenic claudication, which often presents as lower back and extremity pain, numbness, tingling upon ambulation. Autonomic dysfunction rarely observed in patients LSS; however, a subset male has been reported experience intermittent priapism onset claudication symptoms. We present case...