A5047041251- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Meningioma and schwannoma management
- Neural dynamics and brain function
- Neuroscience of respiration and sleep
- Advanced Chemical Sensor Technologies
- Memory and Neural Mechanisms
- Infectious Encephalopathies and Encephalitis
- Cancer-related cognitive impairment studies
- Neurological disorders and treatments
- Simulation-Based Education in Healthcare
- Neurobiology of Language and Bilingualism
- Clinical Reasoning and Diagnostic Skills
- Action Observation and Synchronization
- Brain Metastases and Treatment
- Neuroscience and Neural Engineering
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Heart Rate Variability and Autonomic Control
- Head and Neck Surgical Oncology
Northwestern University
2016-2025
Northwestern Medicine
2025
University of Rochester Medical Center
2024
Haukeland University Hospital
2024
Duke University Hospital
2024
Duke Medical Center
2024
Northwestern Memorial Hospital
2020
Neurology, Inc
2018
Objective Evidence suggests that disordered breathing is critically involved in Sudden Unexpected Death Epilepsy (SUDEP). To end, evaluating structures are activated by seizures and can activate brain regions produce cardiorespiratory changes further our understanding of the pathophysiology SUDEP. Past preclinical studies have shown electrical stimulation human amygdala induces apnea, suggesting a role for controlling respiration. In this study, we aimed to both confirm these findings larger...
The hippocampus supports memory encoding and retrieval, which may occur at distinct phases of the theta cycle. These processes dynamically interact over rapid timescales, especially when sensory information conflicts with memory. ability to link hippocampal dynamics memory-guided behaviors has been limited by experiments that lack temporal resolution segregate retrieval. Here, we simultaneously tracked eye movements field potentials while neurosurgical patients performed a spatial task....
Seizures are a frequent complication of adult-type diffuse gliomas, and often difficult to control with medications. Gliomas mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) more likely than IDH–wild type (IDHwt) gliomas cause seizures as part their initial clinical presentation. However, whether IDHmut is also associated during the remaining disease course, inhibitors can reduce seizure risk, unclear. Clinical multivariable analyses showed that preoperative seizures, glioma location,...
Speech is a critical form of human communication and central to our daily lives. Yet, despite decades study, an understanding the fundamental neural control speech production remains incomplete. Current theories model as hierarchy from sentences phrases down words, syllables, sounds (phonemes), actions vocal tract articulators used produce (articulatory gestures). Here, we investigate cortical representation articulatory gestures phonemes in ventral precentral inferior frontal gyri men...
OBJECTIVE Sudden unexpected death in epilepsy (SUDEP) is the leading cause of for patients with refractory epilepsy, and there increasing evidence a centrally mediated respiratory depression as pathophysiological mechanism. The brain regions responsible seizure’s inducing are unclear—the nuclei brainstem thought to be involved, but involvement forebrain structures not yet understood. aim this study was analyze intracranial EEGs combination results monitoring investigate relationship between...
Nasal inhalation is the basis of olfactory perception and drives neural activity in limbic brain regions. Therefore, our ability to investigate underpinnings olfaction respiration can only be as good characterize features respiratory behavior. However, recordings natural breathing are inherently nonstationary, nonsinusoidal, idiosyncratic making feature extraction difficult automate. The absence a freely available computational tool for characterizing behavior hindrance many facets...
Studies of neuronal oscillations have contributed substantial insight into the mechanisms visual, auditory, and somatosensory perception. However, progress in such research human olfactory system has lagged behind. As a result, electrophysiological properties are poorly understood, and, particular, whether stimulus-driven high-frequency play role odor processing is unknown. Here, we used direct intracranial recordings from piriform cortex during an identification task to show that 3 key...
Epilepsy has a profound impact on quality of life. Despite the development new antiseizure medications (ASMs), approximately one-third affected patients have drug-refractory epilepsy and are nonresponsive to medical treatment. Nearly all currently approved ASMs target neuronal activity through ion channel modulation. Recent human animal model studies implicated immunotherapeutic metabolomic approaches that may benefit with epilepsy. In this Review, we detail proinflammatory immune landscape...
Albeit pervasively underutilized, epilepsy surgery remains the gold standard to achieve seizure freedom in patients with drug resistant (DRE).1, 2 In latest episode of ANA Investigates podcast, Dr. Jon Willie, Associate Professor Department Neurological Surgery at Washington University School Medicine, discusses how technological advances have shifted surgical landscape from large open resections and disconnections minimally invasive approaches. This podcast reviews advantages disadvantages...
Abstract Brain-machine interfaces (BMIs) have advanced greatly in decoding speech signals originating from the motor cortices. Primarily, these BMIs target individuals with intact cortices but who are paralyzed by disrupted connections between frontal and their articulators due to brainstem stroke or neuron diseases such as amyotrophic lateral sclerosis. A few studies shown some information outside cortices, parietal temporal lobes, that also may be useful for BMIs. The ability use lobes...
There are several important interactions between antiepileptic drugs (AEDs) and hormonal contraception that need to be carefully considered by women with epilepsy (WWE) their practitioners. Many AEDs induce hepatic enzymes decrease the efficacy of contraception. In addition, estrogen-containing can increase metabolism lamotrigine, most commonly prescribed AED in childbearing age. The intrauterine device (IUD) is a highly effective form reversible without drug many contraceptive choice for...
Purpose: These American Clinical Neurophysiology Society technical standards suggest best practices for electrical stimulation mapping (ESM) with subdural and stereotactic depth electrodes seizure induction of brain function. Methods: A working group was convened from membership expertise in ESM. PubMed searches were performed to identify pertinent peer-reviewed literature. Recurrent meetings reviewed progress, built consensus by discussion, developed evidence-based recommendations the...
The ability to grasp and manipulate objects requires controlling both finger movement kinematics isometric force in rapid succession. Previous work suggests that these behavioral modes are controlled separately, but it is unknown whether the cerebral cortex represents them differently. Here, we asked question of how were represented cortically, when executed sequentially with same finger. We recorded high-density electrocorticography (ECoG) from motor premotor cortices seven human subjects...
Intraoperative stimulation has emerged as a crucial adjunct in neurosurgical oncology, aiding maximal tumor resection while preserving sensorimotor and language function. Despite increasing use clinical practice of this stimulation, there are limited data on both intraoperative seizure (IS) frequency the presence afterdischarges (ADs) patients undergoing such procedures. The objective study was to determine risk factors for IS or ADs, consequences these events.
The American Board of Psychiatry and Neurology the Accreditation Council for Graduate Medical Education (ACGME) developed Milestones that provide a framework residents' assessment. However, do not description how programs should perform assessments.We evaluated graduating status epilepticus (SE) identification management skills they correlate with ACGME reported epilepsy management/treatment by their program's clinical competency committee (CCC).We performed cohort study neurology residents...