A5019942868- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Glioma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Esophageal Cancer Research and Treatment
- Urological Disorders and Treatments
- Cancer Research and Treatments
- Meningioma and schwannoma management
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Venous Thromboembolism Diagnosis and Management
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Radiotherapy Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Brain Metastases and Treatment
- Epilepsy research and treatment
- Family and Disability Support Research
- Radiomics and Machine Learning in Medical Imaging
- Urinary Bladder and Prostate Research
Northwestern University
2018-2025
Neurological Surgery
2018-2025
Massachusetts General Hospital
2016-2023
Harvard University
2016-2023
Northwestern Medicine
2021-2022
Midwestern University
2022
University of Southern California
2021
National Centre for Biological Sciences
2016
Harvard University Press
2014
Mater Misericordiae University Hospital
2005-2009
Seizures are a frequent complication of adult-type diffuse gliomas, and often difficult to control with medications. Gliomas mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) more likely than IDH–wild type (IDHwt) gliomas cause seizures as part their initial clinical presentation. However, whether IDHmut is also associated during the remaining disease course, inhibitors can reduce seizure risk, unclear. Clinical multivariable analyses showed that preoperative seizures, glioma location,...
Abstract Background Progress in extending the survival of glioblastoma (GBM) patients has been slow. A better understanding why patient remains poor is critical to developing new strategies. Postmortem studies on GBM can shed light are dying. Methods The brains 33 were autopsied and examined for gross microscopic abnormalities. Clinical-pathologic correlations accomplished through detailed chart reviews. Data compared with older published autopsy that predated newer treatment strategies,...
Abstract Mutations in isocitrate dehydrogenases 1 and 2 (IDH mut ) are present a variety of cancers, including glioma, acute myeloid leukemia (AML), melanoma, cholangiocarcinoma. These mutations promote hypermethylation, yet it is only favorable prognostic marker for reasons that unclear. We hypothesized the patterns DNA methylation, transcriptome profiles, would vary among IDH especially gliomas. Using Illumina 450K RNA-Seq data from The Cancer Genome Atlas, we show 365,092 analyzed CpG...
The authors conducted a prospective longitudinal study from 2009 to 2016 assess the short and long-term impact of formal mentorship program on junior faculty satisfaction productivity. Junior mentees enrolled in without were administered surveys before after with their mentoring experiences. Long-term retention, promotion, funding data also collected. Twenty-three 91 controls included study. Mentees came Departments Radiation Oncology Anesthesia, Critical Care, Pain Management. After...
The gene F3, encoding Tissue Factor (TF), is expressed in many cancers and contributes to their malignancy. Among adult-type diffuse gliomas, IDH1/2 wild-type (IDHwt) glioblastomas (GBM) express more TF than mutant (IDHmut) gliomas. Tisotumab vedotin (TisVed), an anti-TF antibody conjugated monomethyl auristatin E, a therapeutic designed target cells expressing TF. We therefore sought determine the potential of TisVed IDHwt vs. IDHmut treated patient-derived glioma with control IgG,...
No AccessJournal of UrologyAdult Urology1 Feb 2018Incidence, Clinicopathological Risk Factors, Management and Outcomes Nonmuscle Invasive Recurrence after Complete Response to Trimodality Therapy for Muscle Bladder Cancer Alejandro Sanchez, Matthew F. Wszolek, Andrzej Niemierko, Rebecca H. Clayman, Michael Drumm, Dayron Rodríguez, Adam S. Feldman, Douglas M. Dahl, Niall Heney, William U. Shipley, Anthony L. Zietman, Jason A. Efstathiou SanchezAlejandro Sanchez Department Urology,...
Gliomas with isocitrate dehydrogenase 1 mutations (IDH1mut) are less aggressive than IDH1 wild-type (IDH1wt) gliomas and have global genomic hypermethylation. Yet it is unclear how specific hypermethylation events contribute to the IDH1mut phenotype. Previously, we showed that gene encoding procoagulant tissue factor (TF), F3, among most hypermethylated downregulated genes in gliomas, correlating greatly reduced thrombosis patients glioma. Because TF also increases aggressiveness of many...
Abstract Purpose: Glioblastoma (GBM) is the most common aggressive primary malignant brain tumor in adults with a median age of onset 68 to 70 years old. Although advanced often associated poorer GBM patient survival, predominant source(s) maladaptive aging effects remains be established. Here, we studied intratumoral and extratumoral relationships between adult patients mice tumors across lifespan. Experimental Design: Electronic health records at Northwestern Medicine NCI SEER databases...
This article describes the development of Parents Plus Early Years Programme (PPEY): a video-based early intervention for parents pre-school children with behavioural and developmental difficulties. PPEY combines individual parent-child sessions using video feedback parenting group teaching over 12-week period. As well as detailing research basis, theory practice PPEY, results an initial study 30 children, range conduct, attention problems whose completed programme. Results showed...
This article describes the development and clinic-based evaluation of Parents Plus Children’s Programme (PPCP), a group-based video-modelling-assisted programme for parents children aged 6 to 11 referred Child Mental Health Service with significant behavioural problems both without associated developmental difficulties. In evaluating programme, sequential block design was used assign 74 service PPCP group ( n = 42) or Treatment as Usual (TAU) Comparison Group 32). Assessment took place...
Abstract Definitive treatment for prostate cancer includes radical prostatectomy ( RP ), external beam radiation therapy EBRT and brachytherapy BT ). The different side effect profiles of these options are crucial factors patients clinicians when deciding between treatments. This study reports long‐term health‐related quality life HRQOL ) in their second decade after cancer. We used a validated survey to assess urinary, bowel, sexual function prospective cohort diagnosed with localized 14–18...
No AccessJournal of UrologyAdult Urology1 Jul 2021Complications and Outcomes Salvage Cystectomy after Trimodality TherapyThis article is commented on by the following:Editorial Comment Alberto Pieretti, Ross Krasnow, Michael Drumm, Andrew Gusev, Douglas M. Dahl, Francis McGovern, L. Blute, William U. Shipley, Jason A. Efstathiou, Adam S. Feldman, Matthew F. Wszolek PierettiAlberto Pieretti Department Urology, The University Texas MD Anderson Cancer Center, Houston, , KrasnowRoss Krasnow...
433 Background: Prior randomized controlled trials (RCT) comparing bladder preservation to radical cystectomy (RC) for muscle invasive cancer (MIBC) closed early due lack of accrual. Given that no future RCTs are foreseen, and in the absence level 1 data, we aimed provide best evidence possible on outcomes matched cohorts trimodality therapy (TMT, maximal transurethral resection tumor followed by concurrent chemoradiation) RC order guide management. Methods: This retrospective analysis...
There is an urgent need for biomarkers of radiation response in organ-sparing therapies. Bladder preservation with trimodality therapy (TMT), consisting transurethral tumor resection followed by chemoradiation, alternative to radical cystectomy muscle-invasive bladder cancer (MIBC), but molecular determinants are poorly understood.