A5083858630- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Colorectal and Anal Carcinomas
- Art Therapy and Mental Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Diagnosis and Treatment
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Advanced biosensing and bioanalysis techniques
- Advances in Oncology and Radiotherapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ethics in Clinical Research
Massachusetts General Hospital
2016-2025
Brigham and Women's Hospital
2022-2024
Harvard University
2016-2024
The University of Texas MD Anderson Cancer Center
2020-2024
Southern Illinois University School of Medicine
2024
Mass General Brigham
2022-2023
Dana-Farber Cancer Institute
2021-2023
Dana-Farber Brigham Cancer Center
2022-2023
Radiation Oncology Associates
2022
National Security Agency
2018
Robot-assisted radical cystectomy is being performed with increasing frequency, but it unclear whether total intracorporeal surgery improves recovery compared open for bladder cancer.
Stimulating the innate immune system has been explored as a therapeutic option for treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations IDH-mutant astrocytomas, have implicated dysfunctional signaling. However, little is known about interplay between ATRX loss and IDH mutation on immunity. To explore this, we generated ATRX-deficient glioma models presence absence IDH1R132H mutation. cells are sensitive to dsRNA-based agonism exhibit impaired lethality...
Pancreatic ductal adenocarcinoma (PDAC) is an invasive and rapidly progressive malignancy. A major challenge in patient management the lack of a reliable imaging tool to monitor tumor response treatment. Tumor-associated fibrosis characterized by high type I collagen hallmark PDAC, further increases neoadjuvant chemoradiotherapy (CRT). We hypothesized that molecular positron emission tomography (PET) using collagen-specific probe,
Importance The value to payers of robot-assisted radical cystectomy with intracorporeal urinary diversion (iRARC) when compared open (ORC) for patients bladder cancer is unclear. Objectives To compare the cost-effectiveness iRARC that ORC. Design, Setting, and Participants This economic evaluation used individual patient data from a randomized clinical trial at 9 surgical centers in United Kingdom. Patients nonmetastatic were recruited March 20, 2017, January 29, 2020. analysis health...
Purpose Chemoradiation-induced lymphopenia is common and associated with poorer survival in multiple solid malignancies. However, the association between chemoradiation-related outcomes rectal cancer yet unclear. The objective of this study was to evaluate prognostic impact its predictors patients undergoing neoadjuvant chemoradiation. Methods inclusion criteria for single-institution retrospective were as follows: (1) biopsy-proven diagnosis adenocarcinoma, (2) receipt chemoradiation...
Ethos adaptive radiotherapy is employed frequently in the pelvis to improve treatment accuracy by adapting daily anatomical changes. The use of this CBCT-guided platform for abdominal treatments made challenging motion-related image artifacts that are detrimental auto-contouring process. We present a preliminary silico study enabled synthetic CBCT data pancreatic cancer. Simulation CT and images were collected from nonadaptive patients treated on Ethos. Contoured CBCTs drove structure-guided...
452 Background: We performed a single-arm phase II study of neoadjuvant NALIRIFOX and chemoradiation (CRT) with concurrent carboplatin/taxol (C/T) followed by surgery in patients locally advanced gastroesophageal (GE) cancer. Methods: Patients were enrolled on an NCI sponsored, prospective, single arm (NCT04656041). Key eligibility criteria included: histologically confirmed T3/4 or lymph node (LN) positive GE junction esophageal cancer, ECOG PS ≤1, age 18+, life expectancy > 3 months....
213 Background: Total neoadjuvant therapy (TNT) is increasingly used for locally advanced rectal cancer. However, which patients benefit most from TNT remains to be elucidated. In this study we sequenced a cohort with long-term follow-up identify genomic correlates of efficacy. Methods: Patients cancer who underwent followed by surgery (Oct 2016-June 2020) were identified at our institution. MSS paired tissues (normal, biopsy, and surgery) successful DNA extraction sequencing analyzed....
The variant rs26232, in the first intron of chromosome 5 open reading frame 30 (C5orf30) locus, has recently been associated with both risk developing rheumatoid arthritis (RA) and severity tissue damage. biological activities human C5orf30 are unknown, neither gene nor protein show significant homology to any other characterized sequences. is present only vertebrate genomes a high degree conservation, implying central function these organisms. Here, we report that highly expressed synovium...
<h3>Background:</h3> Medical students9 comfort level working with dementia is poorly understood, and may impact subsequent experiences patients caregivers. Early that take place in a nonmedical setting allow students to gain more comprehensive understanding of quality life disease management everyday life. <h3>Methods:</h3> We studied Columbia University preclinical medical perceptions relative attending nonclinical art-centered, museum-based experience designed for people their Participants...
In combination with cell intrinsic properties, interactions in the tumor microenvironment modulate therapeutic response. We leveraged high-plex single-cell spatial transcriptomics to dissect remodeling of multicellular neighborhoods and cell-cell human pancreatic cancer associated specific malignant subtypes neoadjuvant chemotherapy/radiotherapy. developed Spatially Constrained Optimal Transport Interaction Analysis (SCOTIA), an optimal transport model a cost function that includes both...
4143 Background: Metastatic pancreatic ductal adenocarcinoma (PDAC) is incurable for most patients. While immune checkpoint inhibitors (ICIs) have limited efficacy in microsatellite stable (MSS) tumors, radiation therapy (RT) may promote responsiveness to ICIs. In our phase 2 trial (NCT03104439), 25 patients with metastatic MSS PDAC were enrolled receive ipilimumab and nivolumab RT (24 Gy/3 fractions) starting on C2D1. The disease control rate (DCR) was 20% (5/25) overall response (ORR) 12%...
Because humans age at different rates, a person's physical appearance may yield insights into their biological and physiological health more reliably than chronological age. In medicine, however, is incorporated medical judgments in subjective non-standardized fashion. this study, we developed validated FaceAge, deep learning system to estimate from easily obtainable low-cost face photographs. FaceAge was trained on data 58,851 healthy individuals, clinical utility evaluated 6,196 patients...
3584 Background: Immune checkpoint inhibitors (ICIs) have limited efficacy in patients with microsatellite stable (MSS) colorectal cancer (CRC). Radiation therapy (RT) may increase the response rate to ICIs through multiple mechanisms. In our phase 2 trial (NCT03104439), 40 metastatic MSS CRC were enrolled receive ipilimumab and nivolumab RT (24 Gy/3 fractions) starting on C2D1. Among 27 who received (33% dropout rate), disease control (DCR) was 37% objective (ORR) 15%. To confirm this...
752 Background: The role of immunotherapy (IO) in microsatellite stable (MSS) pancreatic and colorectal cancer is limited. Stereotactic body radiation therapy (SBRT) increasingly used the limited metastatic setting, however its use with IO remains an area investigation for both target response overall systemic response. Here we evaluate local failure rate irradiated lesions without IO. Methods: We pooled four prospective phase II single-arm studies patients MSS or treated SBRT alone Those...
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 APP