A5057671642- Lanthanide and Transition Metal Complexes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Medical Imaging Techniques and Applications
- Molecular Sensors and Ion Detection
- Advanced MRI Techniques and Applications
- Magnetism in coordination complexes
- Radiopharmaceutical Chemistry and Applications
- Ultrasound and Hyperthermia Applications
- Pancreatic and Hepatic Oncology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Function and Risk Factors
- Effects of Radiation Exposure
- Peptidase Inhibition and Analysis
- Radioactive element chemistry and processing
- Radiomics and Machine Learning in Medical Imaging
- Luminescence and Fluorescent Materials
- Inhalation and Respiratory Drug Delivery
- Orthopedic Infections and Treatments
- Pulmonary Hypertension Research and Treatments
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Electron Spin Resonance Studies
- Crystallography and molecular interactions
- Protein Interaction Studies and Fluorescence Analysis
Athinoula A. Martinos Center for Biomedical Imaging
2019-2024
Harvard University
2020-2024
Massachusetts General Hospital
2019-2024
Institute for Learning Innovation
2023
Medical University of the Americas
2020
Janssen (Belgium)
2020
Pliant (United States)
2020
Durham University
2016-2019
Durham Technical Community College
2016-2019
University of Oxford
2016
Abstract A series of three europium complexes bearing picolyl amine moieties was found to possess differing binding affinities towards Zn 2+ and nucleotides: AMP, ADP, ATP. large increase in the total emission intensity observed upon , followed by signal amplification addition nucleotides. The resulting adducts possessed strong induced circularly polarised emission, with ADP ATP signals opposite sign. Model DFT geometries suggest Δ diastereoisomer is preferred for Λ isomer ADP/AMP. This...
Luminescence spectroscopy has been used to monitor the selective and reversible binding of pH sensitive, macrocyclic lanthanide complexes,<bold>[LnL1]</bold>, serum protein α<sub>1</sub>-AGP, whose concentration can vary significantly in response inflammatory processes.
Pancreatic ductal adenocarcinoma (PDAC) is an invasive and rapidly progressive malignancy. A major challenge in patient management the lack of a reliable imaging tool to monitor tumor response treatment. Tumor-associated fibrosis characterized by high type I collagen hallmark PDAC, further increases neoadjuvant chemoradiotherapy (CRT). We hypothesized that molecular positron emission tomography (PET) using collagen-specific probe,
Electromagnetic susceptibility anisotropy can explain the spectroscopy and magnetism of lanthanide containing systems, but current theories have limitations.
Lanthanide complexes LnL3 (Ln = Sm, Eu, Tb, Dy, Tm, Yb, Lu) with aromatic o-phosphorylated ligands (HL(1) and HL(2)) have been synthesized identified. Their molecular structure was proposed on the basis of a new complex approach, including DFT calculations, Sparkle/PM3 modelling, EXAFS spectroscopy luminescent probing. The photophysical properties all were investigated in detail to obtain deeper insight into energy transfer processes.
A luminescent europium probe has been discovered that binds selectively to drug-site I in human serum albumin, signalled by a ‘switching on’ of emission, and accompanied strong induced circularly polarised luminescence.
Abstract A series of three europium complexes bearing picolyl amine moieties was found to possess differing binding affinities towards Zn 2+ and nucleotides: AMP, ADP, ATP. large increase in the total emission intensity observed upon , followed by signal amplification addition nucleotides. The resulting adducts possessed strong induced circularly polarised emission, with ADP ATP signals opposite sign. Model DFT geometries suggest Δ diastereoisomer is preferred for Λ isomer ADP/AMP. This...
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation complex under enzymatic oxidative conditions led to 1.7-fold increase in r1 at 1.4 T was attributed an oligomerization upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection lung inflammation by MRI bleomycin-injured mice.
The 68Ga-Collagen Binding Probe #8, 68Ga-CBP8, is a peptide-based, type I collagen-targeted probe developed for imaging of tissue fibrosis. aim this study was to determine the biodistribution, dosimetry, and pharmacokinetics 68Ga-CBP8 in healthy human subjects. Methods: Nine volunteers (5 male 4 female) underwent whole-body PET/MRI using Biograph mMR scanner. subjects were imaged continuously up 2 h after injection 68Ga-CBP8. A subset an additional session 2-3 injection. OLINDA/EXM software...
ABSTRACT Novel approaches to the prevention of microbial infections after insertion orthopedic external fixators are in great demand because extremely high incidence rates such infections, which can reach up 100% with longer implant residence times. Monolaurin is an antimicrobial agent a known safety record that broadly used food and cosmetic industries; however, its use coatings medical devices has not been studied much detail. Here, we report monolaurin as antibacterial coating on for...
Selective sensing of glyphosate in the micromolar regime water.
The hypersensitive 2F5/2 to 2F7/2 transition of Yb3+ can be used monitor perturbations the coordination sphere in ytterbium(iii) complexes. An envelope Stark components gives rise a relatively broad and asymmetric emission band, whilst changes their relative intensity energy enable ratiometric response. We report new ytterbium complex with sulphonamide arm that binds reversibly as function pH, giving significant pH dependent Yb spectrum.
We propose a state-of-the-art temporary spacer, consisting of cobalt-chrome (CoCr) femoral component and gentamicin-eluting ultra-high molecular weight polyethylene (UHMWPE) tibial insert, which can provide therapeutic delivery gentamicin, while retaining excellent mechanical properties. The proposed implant is designed to replace conventional spacers made from bone cement.Gentamicin-loaded UHMWPE was prepared using phase-separated compression moulding, its drug elution kinetics,...
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology that characterized by excessive deposition and abnormal remodeling collagen. IPF has mean survival time only 2–5 years from diagnosis, creating need to detect at an earlier stage when treatments might be more effective. We sought develop minimally invasive probe could molecular changes in IPF-associated Here, we describe the design, synthesis, performance [68Ga]Ga·DOTA–CMP, which comprises positron-emitting radioisotope...
Abstract The structural properties of copper complexes with (2‐hydroxyphenyl)di‐ p ‐tolylphosphane oxide (Cu L 1 2 ) and 3‐(2‐hydroxyphenyl)‐3,4‐dihydro‐2 H ‐benzo[ f ][1,5,3]dioxaphosphepine 3‐oxide are studied in detail. o ‐phosphorylated phenols demonstrate both bridging chelating behaviour, the main reaction product is a coordination polymer containing dimeric Cu O 8 fragments. peculiarities were revealed by single‐crystal X‐ray diffraction. powder diffraction, IR, Raman photoelectron...
Copper-64 complex with a new dithiadiaza macrocyclic chelator was evaluated as PET tracer.
Abstract Purpose: One of the major challenges in management pancreatic ductal adenocarcinoma (PDAC) is lack a reliable imaging tool to monitor tumor response treatment. A high degree fibrosis, mainly collagen type I, has been recognized as hallmark PDAC, which further increases neoadjuvant chemoradiotherapy (CRT). This study introduces an image-guided paradigm for monitoring treatment using I specific PET probe, 68Ga-CBP8 mouse models and patients with PDAC. Methods: Subcutaneous human PDAC...
Patients with advanced gastric cancer (GCa) have limited treatment options, and alternative approaches are necessary to improve their clinical outcomes. Because fibrin is abundant in tumors but not healthy tissues, we hypothesized that could be used as a high-concentration depot for high-energy beta-emitting cytotoxic radiopharmaceutical delivered tumor cells. We showed present 64 75% of primary 50 100% metastatic adenocarcinoma cores. First-in-human Cu-FBP8 fibrin–targeted positron emission...