A5017336839- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Cardiac Imaging and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Magnetism in coordination complexes
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound and Hyperthermia Applications
- Liver physiology and pathology
- Effects of Radiation Exposure
- Monoclonal and Polyclonal Antibodies Research
- Ureteral procedures and complications
- Radiation Therapy and Dosimetry
- Kidney Stones and Urolithiasis Treatments
- Gallbladder and Bile Duct Disorders
- Advanced Biosensing Techniques and Applications
- Occupational and environmental lung diseases
Collagen Medical (United States)
2017-2024
Harvard University
2017
Massachusetts General Hospital
2017
Beth Israel Deaconess Medical Center
2005-2009
Justus-Liebig-Universität Gießen
2008
University of Liège
1999-2006
Invisible near-infrared light is safe and it penetrates relatively deeply through tissue blood without altering the surgical field. Our hypothesis was that fluorescence imaging would enable visualization of ureteral anatomy flow intraoperatively in real time.CW800-CA (LI-COR, Lincoln, Nebraska), carboxylic acid form fluorophore IRDye 800CW, injected intravenously, its renal clearance kinetics performance were quantified 350 gm rats 35 kg pigs. High liquid chromatography electrospray...
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, to assess its ability help quantify liver fibrosis in animal models. Materials Methods Biodistribution, pharmacokinetics, stability CM-101 rats were measured with mass spectrometry. Bile duct-ligated (BDL) sham-treated imaged 19 days after procedure by using 1.5-T clinical MR imaging unit. Mice treated carbon tetrachloride (CCl4) or vehicle two...
Abstract Purpose: To evaluate the prognostic value of posttreatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, standard contrast agent, Gd-DOTA, for their abilities identify FOLFIRINOX-induced murine model PDAC. Experimental Design: Ninety-three chemoradiation-treated samples were stained outcomes evaluated. For imaging, C57BL/6 FVB mice orthotopically implanted with cells FOLFIRINOX was administered. Mice imaged Gd-DOTA CM-101. Results: In...
SNIO–CBP, a single-nanometer iron oxide (SNIO) nanoparticle functionalized with type I collagen-binding peptide (CBP), was developed as T 1 -weighted MRI contrast agent only endogenous elements for fast and noninvasive detection of liver fibrosis. SNIO–CBP exhibits 6.7-fold higher relaxivity compared to molecular gadolinium-based CM-101 on per CBP basis at 4.7 T. Unlike most nanoparticles, elimination from the bloodstream 5.7 min half-life, high renal clearance, low, transient enhancement in...
Surgical resection remains a definitive treatment for prostate cancer. Yet, cancer surgery is performed without image guidance tumor margin, extension beyond the capsule and lymph node positivity, verification of other occult metastases in surgical field. Recently, several imaging systems have been described that exploit near-infrared (NIR) fluorescent light sensitive, real-time detection disease pathology intraoperatively. In this study, we describe high-affinity (9 nM), single...
Adamantane scaffolds for affinity maturation of prostate cancer specific ligands low molecular mass are described. These modular and can be used conjugation up to three an additional effector molecule by standard peptide coupling techniques. The potential the is demonstrated with multimerization GPI 1, a small molecule. A detailed study multimerized conjugates near-infrared fluorophores their binding properties different cell lines shows these types positive membrane antigen (PSMA). We...
PhenHDO3A is a ditopic ligand featuring tetraazacyclododecane unit substituted by three acetate arms and one 6-hydroxy-5,6-dihydro-1,10-phenanthroline group (PhenHDO3A = rel-10-[(5R,6R)-5,6-dihydro-6-hydroxy-1,10-phenantholin-5-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid). This was specially designed so as to obtain highly stable heteropolymetallic assemblies. has been prepared starting from phenanthroline epoxide either triprotected or tert-butyl triester of N,N',N'...
Small-molecule ligands specific for prostate-specific membrane antigen (PSMA) have the potential to improve prostate cancer imaging. However, highly charged are difficult label with 99mTc and purify. In this study, we present an adamantane-trimerized small molecule that has nanomolar binding PSMA also 12 negative charges.To convert into a clinically viable SPECT diagnostic, developed simple, cartridge-based, solid-phase prelabeling strategy that, within 25 min, converts readily available...
Abstract The production of disease‐targeted agents requires the covalent conjugation a targeting molecule with contrast agent or therapeutic, followed by purification product to homogeneity. Typical molecules, such as small molecules and peptides, often have high charge‐to‐mass ratios and/or hydrophobicity. Contrast therapeutics themselves are also diverse, include lanthanide chelates for MRI, 99m Tc SPECT, 90 Y radiotherapy, 18 F derivatives PET, heptamethine indocyanines near‐infrared...
High-risk atherosclerosis is an underlying cause of cardiovascular events, yet identifying the specific patient population at immediate risk still challenging. Here, we used a rabbit model atherosclerotic plaque rupture and human carotid endarterectomy specimens to describe potential molecular fibrin imaging as tool identify thrombotic plaques.Atherosclerotic plaques in rabbits were induced using high-cholesterol diet aortic balloon injury (N=13). Pharmacological triggering was group (n=9)...
Liver fibrosis is a common pathway shared by all forms of progressive chronic liver disease. There an unmet clinical need for noninvasive imaging tools to diagnose and stage fibrosis, which presently relies heavily on percutaneous biopsy. Here we explored the feasibility using novel type I collagen-targeted manganese (Mn)-based MRI probe, Mn-CBP20, imaging. In vitro characterization Mn-CBP20 demonstrated its high binding affinity human collagen (Kd = 9.6 µM), T1-relaxivity (48.9 mM-1s-1 at...
Patients with advanced gastric cancer (GCa) have limited treatment options, and alternative approaches are necessary to improve their clinical outcomes. Because fibrin is abundant in tumors but not healthy tissues, we hypothesized that could be used as a high-concentration depot for high-energy beta-emitting cytotoxic radiopharmaceutical delivered tumor cells. We showed present 64 75% of primary 50 100% metastatic adenocarcinoma cores. First-in-human Cu-FBP8 fibrin–targeted positron emission...
Radiation-induced lung injury (RILI) is a progressive inflammatory process commonly seen following irradiation for cancer. The disease can be insidious, often characterized by acute pneumonitis followed chronic fibrosis with significant associated morbidity. No therapies are approved RILI, and accurate quantification major barrier to improved management.
<p>Supplementary Legends, Table</p>
<div>AbstractPurpose:<p>To evaluate the prognostic value of posttreatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, standard contrast agent, Gd-DOTA, for their abilities identify FOLFIRINOX-induced murine model PDAC.</p>Experimental Design:<p>Ninety-three chemoradiation-treated samples were stained outcomes evaluated. For imaging, C57BL/6 FVB mice orthotopically implanted with cells FOLFIRINOX was administered. Mice...
<div>AbstractPurpose:<p>To evaluate the prognostic value of posttreatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, standard contrast agent, Gd-DOTA, for their abilities identify FOLFIRINOX-induced murine model PDAC.</p>Experimental Design:<p>Ninety-three chemoradiation-treated samples were stained outcomes evaluated. For imaging, C57BL/6 FVB mice orthotopically implanted with cells FOLFIRINOX was administered. Mice...
<p>Supplementary figures</p>
<p>Supplementary Legends, Table</p>
<p>Supplementary figures</p>
Objectives: There is a need for better stratification of atherosclerotic patients to identify individuals at high risk cardiovascular event. Two key hallmarks plaque rupture are intraplaque hemorrhage and evidence prior rupture. The protein fibrin strongly associated with both but it not present in earlier stages development, suggesting that imaging would be sensitive versus stable/early disease. Here, we describe properties fibrin-specific PET probe rabbits. Methods: Rabbits were fed...