A5010268909- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Chemical Synthesis and Analysis
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Medical Imaging Techniques and Applications
- Mitochondrial Function and Pathology
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Prion Diseases and Protein Misfolding
- Cerebrovascular and Carotid Artery Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Adenosine and Purinergic Signaling
- Computational Drug Discovery Methods
- Sphingolipid Metabolism and Signaling
- Cholinesterase and Neurodegenerative Diseases
- biodegradable polymer synthesis and properties
- Liver Disease Diagnosis and Treatment
Athinoula A. Martinos Center for Biomedical Imaging
2010-2021
Massachusetts General Hospital
2011-2021
Harvard University
2009-2020
Myongji University
2013
McLean Hospital
2007
Boston University
1999-2002
Significance The periaqueductal gray is a brainstem region that critical for autonomic regulation and defensive responses (e.g., “fight,” “flight,” “freeze”). It has been studied extensively in rodents cats, but less known about the human gray. small size shape of makes it challenging to study using standard noninvasive MRI techniques. We used high-field strength magnet examine this at high resolution while participants viewed emotionally aversive or neutral images. Emotion-related...
Abstract Sphingosine 1-phosphate (SP1) receptors may be attractive targets for modulation of inflammatory processes in neurodegenerative diseases. Recently fingolimod, a functional S1P1 receptor antagonist, was introduced treatment multiple sclerosis. We postulated that anti-inflammatory mechanisms fingolimod might also protective Alzheimer’s disease (AD). Therefore, we treated mouse model AD, the 5xFAD model, with two doses (1 and 5 mg/kg/day) measured response numerous markers Aβ pathology...
The remarkable binding properties of serum albumin have been investigated extensively, but little is known about an important class fatty acids, the very long-chain saturated acids (VLCFA; >18 carbons). Although VLCFA are metabolized efficiently in normal individuals, they markers for and possibly causative agents several peroxisomal disorders. We studied [13C]carboxyl-enriched arachidic (C20:0), behenic (C22:0), lignoceric (C24:0), hexacosanoic (C26:0) to bovine (BSA) by 13C-NMR...
Recent theoretical advances have motivated the hypothesis that periaqueductal gray (PAG) participates in behaviors involve changes autonomic control of visceromotor activity, including during cognitively demanding tasks. We used ultra-high-field (7 tesla) fMRI to measure human brain activity at 1.1 mm resolution while participants completed a working memory task. Consistent with prior work, were less accurate and responded more slowly increasing load—signs task difficulty. Whole-brain...
We examined a novel farnesoid X receptor agonist, EDP‐305, for its antifibrotic effect in bile duct ligation (BDL) and choline‐deficient, L‐amino acid‐defined, high‐fat diet (CDAHFD) models of hepatic injury. used molecular magnetic resonance imaging with the type 1 collagen‐binding probe EP‐3533 oxidized collagen‐specific gadolinium hydrazide to noninvasively measure treatment response. BDL rats (n = 8 each group) were treated either low or high doses EDP‐305 starting on day 4 after imaged...
Abstract Lipid metabolism is abnormal in Alzheimer’s disease (AD) brain leading to ceramide and sphingosine accumulation reduced levels of sphingosine-1-phosphate (S1P). We hypothesize that changes S1P signaling are central the inflammatory immune-pathogenesis AD therapeutic benefits fingolimod, a structural analog FDA approved for treatment multiple sclerosis. recently reported neuroprotective effects fingolimod 5xFAD transgenic mice treated from 1–3 months age were greater at 1 mg/kg/day...
Abstract Relative to common clinical magnetic field strengths, higher fields benefit functional brain imaging both by providing additional signal for high‐resolution applications and improving the sensitivity of endogenous contrast due blood oxygen level dependent (BOLD) mechanism, which has limited detection power at low relative use exogenous agent. This study evaluates utility iron oxide agent gradient echo MRI 9.4 T in rodents using cocaine methylphenidate as stimuli. BOLD method, high...
Abstract Although previous studies of focal hand dystonia have detected cortical sensorimotor abnormalities, little is known about the role basal ganglia in this disorder. We report here that when dystonic patients performed finger‐tapping tasks, functional magnetic resonance imaging showed persisting elevations activity after tasks ended. posit inhibitory control may be faulty dystonia, and increases we observe “resting” mask abnormalities standard contrast analyses.
Abstract We studied the metabolic responses to different DA concentrations elicited by four doses of D‐amphetamine (AMPH, 0, 0.25, 0.5, 1.0, or 3.0 mg/kg). compared degree release (via microdialysis) with striatal cAMP activity and whole brain maps cerebral blood volume (rCBV) changes pharmacological MRI, phMRI). Results: AMPH increased in caudate/putamen (CPu) CPu, nucleus accumbens (NAc), medial prefrontal cortex (mPFC) a linear dose‐dependent manner ( P < 0.0001). The data suggest...
The periaqueductal gray (PAG) is a small midbrain structure that surrounds the cerebral aqueduct, regulates brain–body communication, and often studied for its role in “fight-or-flight” “freezing” responses to threat. We used ultra-high-field 7 T fMRI resolve PAG humans distinguish it from examining vivo function during working memory task ( N = 87). Both mild moderate cognitive demands elicited spatially similar patterns of whole-brain blood oxygenation level-dependent (BOLD) response,...
We investigated the effects of disease progression on brain regional neurochemistry in a mutant mouse model familial amyotrophic lateral sclerosis (FALS; G93A model) using vivo and vitro magnetic resonance spectroscopy (MRS). There were numerous changes spectra that region dependent. At early time points starting around 80 days age there increases glutamate. later more extensive including decreased N-acetyl aspartate glutamate increased glutamine, taurine myo-inositol. The most severe spinal...