A5100719583- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Hepatitis C virus research
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Tea Polyphenols and Effects
- Electrospun Nanofibers in Biomedical Applications
- Adipose Tissue and Metabolism
- Cardiac Fibrosis and Remodeling
- Hepatitis Viruses Studies and Epidemiology
- 3D Printing in Biomedical Research
- Phagocytosis and Immune Regulation
- Single-cell and spatial transcriptomics
- PI3K/AKT/mTOR signaling in cancer
Henan University of Science and Technology
2025
Harvard University
2012-2023
Massachusetts General Hospital
2012-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
China Academy of Chinese Medical Sciences
2023
Chongqing Medical University
2016-2017
Dana-Farber Cancer Institute
2006
Beth Israel Deaconess Medical Center
2006
Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer-related mortality in United States. Because lack viable treatment options for HCC, prevention high-risk patients has been proposed as an alternative strategy. The main risk factor HCC cirrhosis and several lines evidence implicate epidermal growth (EGF) progression development HCC. We therefore examined effects EGF receptor (EGFR) inhibitor erlotinib on liver fibrogenesis hepatocellular transformation three...
Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice.
Accumulating researches have shown that epithelial-mesenchymal transition (EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes, shapes the microenvironment, potentiates migration of breast cancer cells and angiogenesis, is also involved in EMT. However, potential mechanism remains unknown. This study aims explore effect leptin on EMT underlying mechanism. With assessment EMT-associated marker expression MCF-7, SK-BR-3, MDA-MB-468 cells, was analyzed....
Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways and has been reported as biomarker for human hepatocellular carcinoma (HCC). We sought to investigate the mechanism by which SYK promotes liver fibrosis evaluate therapeutic target fibrosis. evaluated cellular localization of association between expression fibrogenesis normal, hepatitis B virus (HBV)‐infected, C (HCV)‐infected non‐alcoholic steatohepatitis (NASH) tissue (n=36, 127, 22 30, respectively). A...
BACKGROUND Hepatocellular carcinoma (HCC)‐associated mortality is increasing at an alarming rate, and there a readily identifiable cohort of at‐risk patients with cirrhosis, viral hepatitis, nonalcoholic fatty liver disease, diabetes. These are candidates for chemoprevention. Metformin attractive agent chemoprevention because it inexpensive, has favorable safety profile, well tolerated over long time periods. METHODS The authors studied the efficacy metformin as prevention in clinically...
Hepatic fibrosis is associated with an overproduction of matrix proteins and a pathological increase liver stiffness. Noninvasive magnetic resonance (MR) quantification can be assessed collagen‐binding molecular MR probe stiffness by elastography, complementary techniques. This study used both imaging techniques to more accurately stage hepatic in rat model. Thirty rats varying levels diethylnitrosamine‐induced were imaged before 45 minutes after injection collagen‐specific EP‐3533....
We examined a novel farnesoid X receptor agonist, EDP‐305, for its antifibrotic effect in bile duct ligation (BDL) and choline‐deficient, L‐amino acid‐defined, high‐fat diet (CDAHFD) models of hepatic injury. used molecular magnetic resonance imaging with the type 1 collagen‐binding probe EP‐3533 oxidized collagen‐specific gadolinium hydrazide to noninvasively measure treatment response. BDL rats (n = 8 each group) were treated either low or high doses EDP‐305 starting on day 4 after imaged...
Abstract Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple robust human cell-based system modeling clinical prognostic signature (PLS) predicting long-term progression toward HCC. Using the PLS as readout, followed by validation in nonalcoholic steatohepatitis/fibrosis/HCC animal patient-derived spheroids,...
Background In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. We hypothesized that MRI with the allysine-targeted probe Gd-oxyamine (OA) could be used to measure this process and noninvasively detect renal fibrosis. Methods Two mouse models were used: hereditary nephritis in Col4a3-deficient mice (Alport model) a glomerulonephritis model, nephrotoxic (NTN). measured difference kidney relaxation rate, ΔR1, after intravenous Gd-OA...
Abstract Hepatocellular carcinoma (HCC) is a highly morbid condition with lack of effective treatment options. HCC arises from chronically inflamed and damaged liver tissue; therefore, chemoprevention may be useful strategy to reduce incidence. Several reports suggest that epigallocatechin gallate (EGCG), extracted green tea, can suppress inflammation fibrosis in animal models, but its role not well established. In this study, male Wistar rats were injected diethylnitrosamine at 50 mg/kg for...
A recent gene expression classification of hepatocellular carcinoma (HCC) includes a poor survival subclass termed S2 representing about one-third all HCC in clinical series. cells express E-cadherin and c-myc secrete AFP. As the fibroblast growth factor receptors (FGFRs) differs between non-S2 HCC, this study investigated whether molecular subclasses predict sensitivity to FGFR inhibition. cell lines were significantly more sensitive (p < 0.001) inhibitors BGJ398 AZD4547. decreased MAPK...
WISP2 is a novel adipokine, most highly expressed in the adipose tissue and primarily undifferentiated mesenchymal cells. As secreted protein, it an autocrine/paracrine activator of canonical WNT signaling and, as intracellular helps to maintain precursor cells undifferentiated. To examine effects increased vivo, we generated aP2-WISP2 transgenic (Tg) mouse. These mice had serum levels WISP2, lean body mass whole energy expenditure, hyperplastic brown/white tissues larger hearts. Obese Tg...
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, hepatocellular carcinoma (HCC) chronic hepatitis C. Whether these SNPs independently or combination predict clinical deterioration C virus (HCV)-related cirrhosis is unknown. We genotyped EGF, PNPLA3, IL28B from liver tissue 169...
Myocardial fibrosis (MF) is the characteristic pathological feature of various cardiovascular diseases that lead to heart failure (HF) or even fatal outcomes. Alternatively, activated macrophages are involved in development and tissue remodeling. Although receptor for advanced glycation end products (RAGE) MF, its potential role regulating macrophage function cardiac has not been fully investigated. We aimed determine RAGE transverse aortic constriction (TAC)-induced MF. In this study, we...
Tamoxifen has been reported to be associated with antagonism of estrogen-mediated cell growth signaling and activation estrogen receptor–independent apoptosis events. It demonstrated that mammalian sterile 20-like kinase 1 is a direct target Caspases amplify the apoptotic pathway. Here, we presented breast cancer MCF-7 SKBR3 cells under treatment 4-hydroxytamoxifen displayed decreased level pyruvate M2. Western blot results also showed induced activity pro-apoptotic protein Caspase-3 in...