A5049112383- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Tracheal and airway disorders
- Transplantation: Methods and Outcomes
- Pluripotent Stem Cells Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- 3D Printing in Biomedical Research
- Systemic Sclerosis and Related Diseases
- Lung Cancer Diagnosis and Treatment
- Congenital heart defects research
- Organ Transplantation Techniques and Outcomes
- Angiogenesis and VEGF in Cancer
- Cardiac Structural Anomalies and Repair
- Respiratory Support and Mechanisms
- Cardiac Valve Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Bone Tissue Engineering Materials
- Mechanical Circulatory Support Devices
- Medical Imaging and Pathology Studies
- Cardiac and Coronary Surgery Techniques
- Esophageal and GI Pathology
- Xenotransplantation and immune response
Harvard University
2015-2024
Massachusetts General Hospital
2015-2024
Thoracic Surgery Foundation
2021-2024
MedStar Georgetown University Hospital
2022
Georgetown University
2022
California Institute for Regenerative Medicine
2021-2022
McGill University
2019
Harvard Stem Cell Institute
2011-2018
University Hospital Münster
2018
Technische Universität Berlin
2017
Rationale: More than 25 million individuals have heart failure worldwide, with ≈4000 patients currently awaiting transplantation in the United States. Donor organ shortage and allograft rejection remain major limitations only ≈2500 hearts transplanted each year. As a theoretical alternative to allotransplantation, patient-derived bioartificial myocardium could provide functional support ultimately impact treatment of failure. Objective: The objective this study is translate previous work...
Background— The importance and therapeutic value of stem cells in lymphangiogenesis are poorly understood. We evaluated the potential human murine mesenchymal (MSCs) to acquire a lymphatic phenotype vitro enhance regeneration vivo. Methods Results— assessed lymphendothelial differentiation MSCs after induction with supernatant derived from dermal microvascular endothelial cells, isolated purified vascular growth factor (VEGF)-C vitro. used or progenitor MSC lines then characterized by...
Abstract Patients with short bowel syndrome lack sufficient functional intestine to sustain themselves enteral intake alone. Transplantable vascularized bioengineered could restore nutrient absorption. Here we report the engineering of humanized intestinal grafts by repopulating decellularized rat matrix human induced pluripotent stem cell-derived epithelium and endothelium. After 28 days in vitro culture, hiPSC-derived progenitor cells differentiate into a monolayer polarized epithelium....
Skeletal muscle harbors quiescent stem cells termed satellite and proliferative progenitors myoblasts, which play pivotal roles during regeneration. However, current technology does not allow permanent capture of these cell populations in vitro. Here, we show that ectopic expression the myogenic transcription factor MyoD, combined with exposure to small molecules, reprograms mouse fibroblasts into expandable induced progenitor (iMPCs). iMPCs express key skeletal markers including Pax7 Myf5...
Bioengineering of viable, functional, and implantable human lung grafts on porcine matrix.Implantable bioartificial organ could revolutionize transplant surgery. To date, several milestones toward that goal have been achieved in rodent models. make bioengineered clinically relevant, scaling to cells graft size are the next steps.We seeded decellularized scaffolds with airway epithelial progenitor derived from rejected donor lungs, banked umbilical vein endothelial cells. We subsequently...
Idiopathic pulmonary fibrosis (IPF) affects the subpleural lung but is considered to spare small airways. Micro-computed tomography (micro-CT) studies demonstrated airway reduction in end-stage IPF explanted lungs, raising questions about involvement early-stage disease. Endobronchial optical coherence (EB-OCT) a volumetric imaging modality that detects microscopic features from proximal