Leopoldo Fernandez

ORCID: 0009-0008-6943-0427
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Intraperitoneal and Appendiceal Malignancies
  • Breast Cancer Treatment Studies
  • Ovarian cancer diagnosis and treatment
  • Appendicitis Diagnosis and Management
  • Breast Lesions and Carcinomas
  • Nutrition and Health in Aging
  • Breast Implant and Reconstruction
  • Gastric Cancer Management and Outcomes
  • Medical Imaging Techniques and Applications
  • Anesthesia and Pain Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Enhanced Recovery After Surgery
  • Colorectal Cancer Surgical Treatments
  • Digital Radiography and Breast Imaging
  • Colorectal Cancer Screening and Detection
  • Vascular Procedures and Complications
  • Renal and Vascular Pathologies
  • Chronic Kidney Disease and Diabetes
  • Multiple and Secondary Primary Cancers
  • Cardiovascular and Diving-Related Complications
  • Nausea and vomiting management
  • Cutaneous lymphoproliferative disorders research
  • Proteoglycans and glycosaminoglycans research
  • Esophageal Cancer Research and Treatment
  • Organ and Tissue Transplantation Research

Virginia Commonwealth University
2015-2024

VCU Massey Comprehensive Cancer Center
2023-2024

VA Central California Health Care System
2024

Children's Hospital of Richmond at VCU
2024

Hunter Holmes McGuire VA Medical Center
2019-2023

Virginia Cancer Institute
2023

University of Richmond
2023

Kharkiv University of Air Force
2023

University Health System
2019

Virginia Commonwealth University Medical Center
2017-2018

Micro-CT is a promising modality to determine breast tumour size in three dimensions intact lumpectomy specimens. We compared the accuracy of measurements using specimen micro-CT with multimodality pre-operative imaging.A tabletop was used image The largest dimension on three-dimensional reconstructed images determined by mammography, ultrasound and MRI. pathologic invasive cancer as gold standard reference assess imaging assessments.50 specimens 50 patients had imaging. 42 were ductal...

10.1259/bjr.20150581 article EN British Journal of Radiology 2015-11-16

Microscopically clear lumpectomy margins are essential in breast conservation, as involved increase local recurrence. Currently, 18-50% of lumpectomies have close or positive that require re-excision. We assessed the ability micro-computed tomography (micro-CT) to evaluate shaved cavity (SCM) intraoperatively determine if this technology could rapidly identify margin involvement by tumor and reduce re-excision rates. Twenty-five SCM from six were evaluated with a Skyscan 1173 table top...

10.1111/tbj.12146 article EN The Breast Journal 2013-06-01

Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic sulfate groups. Devising an approach for oral delivery such highly sulfated molecules would be very useful. This work presents the concept that conjugating cholesterol GAG enables delivery. A focused library was synthesized and found inhibit growth a colorectal cancer cell line under spheroid conditions with wide range potencies ( 0.8...

10.1021/acs.jmedchem.2c01511 article EN cc-by-nc-nd Journal of Medicinal Chemistry 2023-01-12

BACKGROUND Regional nerve blocks ideally provide safe and effective post-operative pain control, decrease opiate requirements, enhance recovery from intense following major thoracic, abdominal, musculoskeletal surgeries. The erector spinae plane block, a recently described novel treatment for chronic neuropathic acute after thoracic surgery, can be performed with in infiltration placement of continuous infusion catheter deep to the muscle at tip transverse process, resulting diffusion local...

10.12659/ajcr.921123 article EN American Journal of Case Reports 2020-01-28

Despite our most advanced medical and surgical treatment 40,000 women die from breast cancer each year. The aging population their increasing burden of comorbidities may not be able to realize the full benefit treatments due a combination side effects patient frailty. aim this study was characterize patients determine if number is significant contributor survival.A database including year 2002 2012 created include health electronic record. Patients were classified into groups according...

10.21037/gs.2018.02.03 article EN Gland Surgery 2018-04-01

A 54-year-old African-American male presented to the colorectal surgery clinic with chief complaint of a painful anal swelling that had been ongoing for several weeks. An adequate rectal examination was not possible due severe pain. Therefore, he taken operating room an exam under anesthesia where presacral mass identified. transgluteal core needle biopsy performed which consistent gastrointestinal stromal tumor. Computed tomography imaging identified 16 cm ×10 ×9 cmrectal Given size and...

10.1177/2050313x231211124 article EN cc-by-nc SAGE Open Medical Case Reports 2024-01-01

Histopathology is the only accepted method to measure and stage breast tumor size. However, there a need find another size when pathological assessment not available. Micro-computed tomography. (micro-CT) has ability in three dimensions an intact lumpectomy specimen. In this study, we aimed determine accuracy of micro-CT primary specimens, as compared histopathology.Seventy-two women who underwent surgery at Massachusetts General Hospital Department Surgery from June 2011 September 2011,...

10.4103/2153-3539.170647 article EN cc-by-nc-sa Journal of Pathology Informatics 2015-01-01

Open cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a therapeutic option for the management of malignancies peritoneal carcinomatosis and origin. Robotic shows promise as minimally invasive approach select patients. We aimed to evaluate differences in outcomes between robotic versus open CRS/HIPEC hypothesized less morbidity faster recovery group.

10.1007/s00464-024-11199-7 article EN cc-by Surgical Endoscopy 2024-10-16

Appendiceal cancer treatment may include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We investigated whether patient race/ethnicity influences outcomes overall survival for patients with appendiceal who undergo CRS/HIPEC. queried the National Cancer Database adult treated CRS/HIPEC from 2006 to 2018. Patients were stratified by race/ethnicity: non-Hispanic White (NHW), Black (NHB), Hispanic, Other. Sociodemographics compared using descriptive statistics....

10.3390/cancers15153990 article EN Cancers 2023-08-06

Abstract Redlining refers to the practice of classifying neighborhoods with racial minorities and low-income residents as “hazardous” for investors. This discriminatory by Home Owners’ Loan Corporation (HOLC) has been shown impact patient cancer incidence outcomes in breast, lung, cervical, colorectal cancers. In this study, we evaluate HOLC status on pancreatic ductal adenocarcinoma (PDAC) Virginia. The Virginia Department Health Cancer Registry was queried adult patients diagnosed from...

10.1158/1538-7445.am2024-2248 article EN Cancer Research 2024-03-22

Smith, Steven Christopher MD, PhD; Diaz-Perez, Julio A. Mochel, Mark Cameron MD; Billings, D. Fernandez, Leopoldo Poklepovic, Andrew S. MD Author Information

10.1097/pas.0000000000002326 article EN The American Journal of Surgical Pathology 2024-11-04

10.1016/s1078-5884(05)80143-1 article EN publisher-specific-oa European Journal of Vascular and Endovascular Surgery 1995-04-01

The objective of the 2006–07 Virginia Tech Turbocharger Project was to obtain and analyze vibrations data from different bearing designs. supporting tasks were divided amongst various sub-teams; a turbocharger team, an engine test operating dynamometer ADRE software team. team has successfully developed procedure for disassembly reassembly turbocharger. A consistent well-documented assembly ensured operation free human error. Consistency in rebuild process is vital properly compare vibration...

10.1115/ijtc2007-44417 article EN ASME/STLE 2007 International Joint Tribology Conference, Parts A and B 2007-01-01

Background and Objectives: Enhanced recovery after surgery (ERAS) pathways are associated with better postoperative recovery; however, evidence is lacking in liver cancer surgery. This study aimed to evaluate the impact of an ERAS pathway US veterans undergoing Methods: We initiated for preoperative, intraoperative, interventions, which included a novel regional anesthesia technique, erector spinae plane block, multimodal analgesia management. A retrospective quality improvement was...

10.1097/qmh.0000000000000389 article EN Quality Management in Health Care 2023-03-06

•Metastatic disease to the small bowel may present with intussusception.•Clinical decision making for malignant obstruction is difficult and individual specific.•Malignant due metastatic year has an average life expectancy of less than 200 days.

10.1016/j.gore.2023.101306 article EN cc-by-nc-nd Gynecologic Oncology Reports 2023-11-22

Advanced cancer states perpetuate health-related disparities. Peritoneal-based cancers are clinically advanced that present a significant clinical dilemma. Peritoneal managed aggressively with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). While racial ethnic disparities prevalent in cancer, there no studies investigating if exist patients peritoneal carcinomatosis CRS HIPEC. We hypothesized this disease state further delineates disparities.A retrospective...

10.3389/fonc.2022.899488 article EN cc-by Frontiers in Oncology 2022-06-08
Coming Soon ...