A5087118610- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Cardiac, Anesthesia and Surgical Outcomes
- Sirtuins and Resveratrol in Medicine
- Infant Nutrition and Health
- Ovarian cancer diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Frailty in Older Adults
- Cancer Genomics and Diagnostics
- Appendicitis Diagnosis and Management
- Organ Donation and Transplantation
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Mitochondrial Function and Pathology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Surgical Simulation and Training
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease Diagnosis and Treatment
- Breastfeeding Practices and Influences
- Hip and Femur Fractures
- Phagocytosis and Immune Regulation
- Renal Transplantation Outcomes and Treatments
Virginia Commonwealth University
2022-2025
Virginia Cancer Institute
2025
VCU Massey Comprehensive Cancer Center
2025
Hunter Holmes McGuire VA Medical Center
2021-2024
VA Central California Health Care System
2022-2024
Saint John's Health Center
2019-2022
St. John's School
2021
Jewish Hospital
2018
Northwell Health
2018
Hofstra University
2013-2017
Sepsis refers to severe systemic inflammation leading acute lung injury (ALI) and death. Introducing novel therapies can reduce the mortality in ALI. Osteopontin (OPN), a secretory glycoprotein produced by immune reactive cells, plays deleterious role various inflammatory diseases. However, its ALI caused sepsis remains unexplored. We hypothesize that treatment with an OPN-neutralizing antibody (anti-OPN Ab) protects mice against during sepsis.Sepsis was induced 8-week-old male C57BL/6 cecal...
Cold-inducible RNA-binding protein (CIRP) is a nuclear that has been recently identified as novel inflammatory mediator in hemorrhagic shock and sepsis. We hypothesized CIRP acts potent hepatic ischemia-reperfusion (I/R), thus blocking protects against I/R-induced liver injury. Male C57BL/6 mice were subjected to 70% ischemia by microvascular clamping of the hilum left median lobes for 60 min, followed reperfusion. Anti-CIRP antibody (1 mg/kg body weight) or vehicle (normal saline) 0.2 mL...
Background Renal ischemia-reperfusion (I/R) is a major contributor to delayed graft function after renal transplantation. The pathophysiology of I/R can be summarized by primary energy deficit during ischemia and secondary phase oxidative stress inflammation. Sirtuin 1 an energy-sensing enzyme involved in regulating multiple cellular functions. We hypothesized that stimulating would increase mitochondrial biogenesis thereby enhancing metabolism attenuating I/R-induced injury. Methods Adult...
Hepatic ischemia-reperfusion is a major clinical problem with limited treatment options. The pathophysiology of hepatic characterized by mitochondrial dysfunction and cellular energy deficits. Sirtuin 1 an energy-sensing enzyme known to modulate biogenesis. We hypothesized that pharmacologic activation sirtuin protective after injury.Animal study.University-based experimental laboratory.Wild-type C57BL/6 mice.C57BL/6 mice were subjected 60-minute partial posttreated activator, SRT1720 (20...
Renal ischemia-reperfusion (IR) injury (IRI) after shock states or transplantation causes tissue damage and delayed graft function, respectively. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis. We therefore hypothesized that pharmacological activation of the by Wnt agonist, synthetic pyrimidine, could protect kidneys from IRI. Adult male rats were subjected to bilateral clamping renal pedicles with microvascular clips for 60 min, followed reperfusion. agonist (5...
Abstract Background: Colorectal cancer (CRC) is the third most common worldwide. Tumors, often described as wounds that do not heal, exhibit fibrin clot deposition, which may create a niche for stem cells (CSCs). Factor XIII (FXIII), transglutaminase, cross-links (XLF) and functionalizes XLF clots by incorporating additional protein into matrix. Our previous studies suggest FXIII-XLF promotes CSC phenotype. This study aims to identify validate CSC-promoting proteins enriched in Methods: TCGA...
Abstract Background: Total neoadjuvant therapy for rectal cancer has emerged as a favorable treatment plan. However, definitive algorithm not been identified. Our study compares pathological response rates induction regarding short and long course radiation across various demographic disease-specific criteria. Methods: Using the National Cancer Database (NCDB), data were collected patients with clinical stage II III who underwent chemoradiation either or from 2004-2021. Chi-squared test was...
Abstract Colorectal cancer (CRC) is highly treatable when localized, but survival drops sharply with metastasis, especially to the peritoneum (PM). CRC PM particularly resistant chemotherapy, emphasizing need for models that replicate disease biology use in drug discovery. Our study establishes reproducible patient-derived xenografts (PDX) from a racially diverse patient population. Patients were recruited tissue collection at single academic tertiary care center. Tumor samples collected...
Intestinal ischemia-reperfusion (I/R) occurs in various clinical situations and causes local remote organ injury, especially the lungs, leading to significant morbidity mortality. The maintenance of mitochondrial biogenesis is essential for cell survival regulated part by sirtuin 1 (SIRT1), an energy-sensing enzyme. We hypothesized that SIRT1 activation with SRT1720 would reduce injury after intestinal I/R. I/R was induced occlusion superior mesenteric artery adult male C57BL/6 mice 45 min,...
Hemorrhagic shock is a leading cause of morbidity and mortality in surgery trauma patients. Despite large number preclinical trials conducted to develop therapeutic strategies against hemorrhagic shock, there still an unmet need for effective therapy hemorrhage Wnt/β-catenin signaling controls developmental processes cellular regeneration owing its central role cell survival proliferation. We therefore hypothesized that the activation Wnt reduces systemic injury caused by shock.Adult male...
Abstract Background Given the survival advantage of neoadjuvant treatment for locally advanced esophageal cancer, accurate clinical staging is necessary. The aim this study was to assess (c) and pathologic (p) concordance rates presumably early stage adenocarcinoma patients that had upfront esophagectomy (UFE) evaluate if (OS) negatively affected by inaccurate preoperative subsequent selection. Methods An NCDB retrospective review nonmetastatic UFE. between c p system OS were calculated....
A 54-year-old African-American male presented to the colorectal surgery clinic with chief complaint of a painful anal swelling that had been ongoing for several weeks. An adequate rectal examination was not possible due severe pain. Therefore, he taken operating room an exam under anesthesia where presacral mass identified. transgluteal core needle biopsy performed which consistent gastrointestinal stromal tumor. Computed tomography imaging identified 16 cm ×10 ×9 cmrectal Given size and...
Open cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a therapeutic option for the management of malignancies peritoneal carcinomatosis and origin. Robotic shows promise as minimally invasive approach select patients. We aimed to evaluate differences in outcomes between robotic versus open CRS/HIPEC hypothesized less morbidity faster recovery group.
Selecting frail elderly patients with pancreatic cancer (PC) for pancreas resection using biologic age has not been elucidated. This study determined the feasibility of deficit accumulation frailty index (DAFI) in identifying such and its association surgical outcomes.The DAFI, which assesses based on age, was used to identify clinical health-related quality-of-life data. The characteristics nonfrail were compared.Of 242 (median 75.5 years), 61.2% 32.6% had undergone (surgery group). Median...
Abstract Background and Objectives Most breast cancer (BC) patients present with early disease clinically negative lymph nodes (cN0). Timing of surgery has not been standardized. We hypothesized that surgical delay results in an increased likelihood nodal metastasis. Methods Patients diagnosed cN0 BC undergoing sentinel node biopsy as initial therapy between 2006 2014 were identified the NCDB divided into four groups based on time intervals diagnosis (<4 weeks, 4–8 8–12 >12 weeks)....