A5037493753- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Enhanced Recovery After Surgery
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- Tracheal and airway disorders
- Appendicitis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- COVID-19 diagnosis using AI
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Patient Safety and Medication Errors
- Trauma and Emergency Care Studies
- Respiratory viral infections research
- Climate Change and Health Impacts
- Anesthesia and Sedative Agents
- Medical Malpractice and Liability Issues
- Abdominal Surgery and Complications
- Surgical Simulation and Training
- Pain Management and Opioid Use
- Colorectal Cancer Surgical Treatments
- Otolaryngology and Infectious Diseases
- Hemodynamic Monitoring and Therapy
University College London
2013-2024
University College Hospital
2015-2024
Co-operative College
2024
Mubadala (United Arab Emirates)
2024
University College London Hospitals NHS Foundation Trust
2018-2023
University of Southampton
2022
Royal London Hospital
2022
West Hertfordshire Hospitals NHS Trust
2020-2021
Target (United States)
2021
Royal College of Anaesthetists
2015-2020
Abstract Background older patients aged ≥65 years constitute the majority of National Emergency Laparotomy Audit (NELA) population. To better understand this group and inform future service changes, paper aims to describe patient characteristics, outcomes process measures across age cohorts temporally in 4-year period (2014–2017) since NELA was established. Methods patient-level data were populated from set 1–4 linked with Office Statistics mortality data. Descriptive compared between groups...
Summary Acute postoperative pain is common, distressing and associated with increased morbidity. Targeted interventions can prevent its development. We aimed to develop internally validate a predictive tool pre‐emptively identify patients at risk of severe following major surgery. analysed data from the UK Peri‐operative Quality Improvement Programme logistic regression model predict on first day using pre‐operative variables. Secondary analyses included use peri‐operative Data 17,079...
Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring laparotomy managed by general surgeons an elective special interest focused on either upper or lower tract. This study investigated impact mortality after laparotomy.Adult patients having colorectal gastroduodenal were identified from National Emergency Laparotomy Audit database grouped according to operative procedure. Outcomes included...
Identify predictors of clinical deterioration in a virtual hospital (VH) setting for COVID-19.Real-world prospective observational study.VH remote assessment service West Hertfordshire NHS Trust, UK.Patients with suspected COVID-19 illness enrolled directly from the community (postaccident and emergency (A&E) or medical intake assessment) postinpatient admission.Death (re-)admission to inpatient care during VH follow-up 2 weeks post-VH discharge.900 patients diagnosis (455 referred A&E 445...
Enhanced recovery pathways are associated with improved postoperative outcomes. However, as enhanced have become more complex and varied, compliance has reduced. The 'DrEaMing' bundle re-prioritises early delivery of drinking, eating, mobilising. We investigated relationships between DrEaMing compliance, hospital length stay (LOS), complications in a prospective multicentre major surgical cohort.
Summary The probability of death after emergency laparotomy varies greatly between patients. Accurate pre‐operative risk prediction is fundamental to planning care and improving outcomes. We aimed develop a model limited few factors that performed well irrespective surgical indication: obstruction; sepsis; ischaemia; bleeding; other. derived with data from the National Emergency Laparotomy Audit for patients who had December 2016 November 2018. tested on underwent 2018 2019. There were...
Summary Complications are common following major surgery and associated with increased use of healthcare resources, disability mortality. Continued reliance on mortality estimates risks harming patients health systems, but existing tools for predicting complications unwieldy inaccurate. We aimed to systematically construct an accurate pre‐operative model postoperative complications; compare its performance against tools; identify sources inaccuracy in predictive models more generally....
Abstract This protocol contains the steps and dosages used for acute in vivo integrated stress response activation experiment using tunicamycin treatment young mice (P12-14). (Wang et al., 2015) indicates may not be as effective older mice.
<ns4:p>We present two cases of coronavirus disease 2019 (COVID-19)-related laryngotracheitis in good-prognosis, ventilated patients who had failed extubation. As the pandemic continues to unfold across globe and better management those with respiratory failure develops, this may be an increasingly common scenario. Close ENT-intensivist liaison, meticulous team preparation, early consideration rigid endoscopy prospective data collection case sharing are recommended.</ns4:p>
Summary Pre‐operative anaemia is associated with poor outcomes after elective surgery but its relationship emergency unclear. We analysed National Emergency Laparotomy Audit data from 1 December 2013 to 30 November 2017, excluding laparotomy for haemorrhage. Anaemia was classified as ‘mild’ 129–110 g.l−1; ‘moderate’ 109–80 or ‘severe’ ≤ 79 g.l−1. The primary outcome 90‐day mortality. Secondary were 30‐day mortality, return theatre and postoperative hospital stay. available 86,763 patients,...
Summary Pregnant women should receive information about what they might expect to experience during their delivery. Despite this, research shows many are inadequately prepared for anaesthetic interventions labour. We surveyed 903 postnatal across 28 Greater London hospitals about: the analgesic and that recalled receiving pregnancy delivery; confidence make decisions on analgesia; satisfaction with analgesia used. Wide variation was observed between hospitals. Overall, 67 of 749 (9.0%)...
Over 1.5 million major surgical procedures take place in the UK NHS each year and approximately 25% of patients develop at least one complication. The most widely used risk-adjustment model for postoperative morbidity is physiological operative severity score enumeration mortality morbidity. However, this was derived more than 30 years ago now overestimates risk In addition, contemporary definitions some predictors are markedly different compared with when tool developed. A second clinical...
Abstract Background Pulmonary complications are the most common morbidity after oesophagectomy, contributing to mortality and prolonged postoperative recovery, have a negative impact on health-related quality of life. A variety single or bundled interventions in perioperative setting been developed reduce incidence pulmonary complications. Significant variation practice exists across UK. The aim this modified Delphi consensus was deliver clear evidence-based recommendations regarding...