A5050419318- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Surgical Simulation and Training
- Acute Kidney Injury Research
- Cancer-related gene regulation
- Anatomy and Medical Technology
- Enhanced Recovery After Surgery
- Mathematical Biology Tumor Growth
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diverticular Disease and Complications
- Pancreatic and Hepatic Oncology Research
- Amoebic Infections and Treatments
- Aortic aneurysm repair treatments
- Histone Deacetylase Inhibitors Research
- Simulation-Based Education in Healthcare
- Surgical Sutures and Adhesives
- Abdominal Surgery and Complications
- Surgical site infection prevention
University of Southampton
2021-2025
University Hospital Southampton NHS Foundation Trust
2022-2024
Southampton General Hospital
2021-2022
Portsmouth Hospitals NHS Trust
2022
Cancer Research UK
2022
Isle of Wight NHS Trust
2020-2021
St Mary's Hospital
2020-2021
St. Mary's Hospital
2020-2021
Flinders Medical Centre
2021
University of Birmingham
2020
This study aimed to evaluate the educational impact of integrated haptic feedback in an immersive VR bone drilling simulation on performance a cohort junior surgeons.Block randomised, controlled, double-blinded study.St Georges University Hospital, London, United Kingdom.and methods: 31 trainee doctors (postgraduate years 1-3) with limited orthopaedic experience were recruited participate this randomised controlled through e-mail and poster advertising. They allocated or non-haptic group...
Laparoscopic rectal surgery in obese patients is technically challenging. The technological advantages of robotic instruments can help overcome some those challenges, but whether this translates to superior short-term outcomes largely unknown. aim study compare the surgical (BMI ≥ 30) and laparoscopic cancer patients. All consecutive receiving resection from three centres, two UK one Portugal, between 2006 2017 were identified prospectively collated databases. Robotic propensity score...
Abstract Background Anti-programmed cell death protein1 (anti-PD-1) based immunotherapies improve survival in oesophageal adenocarcinoma (OAC) patients, but not all patients benefit. Inhibitors of the histone methyltransferase EZH2 (EZH2i) have been shown upregulate major histocompatibility complex (MHC) class I and II expression which overcame anti-PD-1 resistance other cancers. This vitro study assessed efficacy EZH2i their impact on MHC OAC. Methods Three OAC lines (FLO1, MFD1, OE33) a...
The tumor microenvironment (TME) comprises all non-tumor elements of cancer and strongly influences disease progression phenotype. To understand biology accurately test new therapeutic strategies, representative models should contain both cells normal the TME. Here we describe characterize co-culture tumor-derived organoids cancer-associated fibroblasts (CAFs), a major component TME, in matrix-embedded assembloid esophageal adenocarcinoma (EAC). We demonstrate that faithfully recapitulate...
The tumor microenvironment (TME) comprises all non-tumor elements of cancer and strongly influences disease progression phenotype. To understand biology accurately test new therapeutic strategies, representative models should contain both cells normal the TME. Here, we describe characterize co-culture tumor-derived organoids cancer-associated fibroblasts (CAFs), a major component TME, in matrix-embedded assembloid esophageal adenocarcinoma (EAC). We demonstrate that faithfully recapitulate...
Robotic systems are designed to address the limitations of laparoscopic surgery, leading a growing interest in robotic rectal surgery. However, certain technical associated with previous (da Vinci S & Si) have arguably slowed down its wholesale adoption. The latest platform, da Xi, addresses these limitations. This study aims examine short-term surgical outcomes 240 single-docking fully-robotic cancer resections and compare cases performed Xi vs Si systems. All consecutive patients receiving...
Abstract Background Pulmonary complications are the most common morbidity after oesophagectomy, contributing to mortality and prolonged postoperative recovery, have a negative impact on health-related quality of life. A variety single or bundled interventions in perioperative setting been developed reduce incidence pulmonary complications. Significant variation practice exists across UK. The aim this modified Delphi consensus was deliver clear evidence-based recommendations regarding...
We utilized a population dataset to compare outcomes for patients where surgery was independently performed by trainees cases led consultant.Emergency laparotomy is common, high-risk, procedure. Although trainee involvement improve future surgeons' experience and ability in the management of such crucial, some studies have suggested this detriment patient outcomes. In UK, appropriately skilled may be entrusted perform emergency without supervision consultant (attending).Patients who...
<h3>Background</h3> Pleural tuberculosis (TB) is one of the most common forms extrapulmonary TB, reported to account for up 25% TB infected adults, and 30% exudative pleural effusions in developing countries. Despite this, little information has been on its incidence within London. <h3>Aims methods</h3> A retrospective observational study was performed at a London tertiary referral centre. The aim identify contribution overall burden both disease, assess diagnostic yields investigation...
Abstract The tumor microenvironment (TME) comprises all non-tumor elements of cancer and strongly influences disease progression phenotype. To understand biology accurately test new therapeutic strategies, representative models should contain both cells normal the TME. Here we describe characterize co-culture tumor-derived organoids cancer-associated fibroblasts (CAFs), a major component TME, in matrix-embedded assembloid esophageal adenocarcinoma (EAC). We demonstrate that faithfully...
A 50-year-old gentleman whilst undergoing neoadjuvant chemotherapy for rectal cancer underwent an emergency Hartman’s procedure a stercoral perforated rectosigmoid colon. One week post-operatively the patient became persistently pyrexial with rising inflammatory markers, two days after withdrawal of abdominal 20 F drain. CT abdomen and pelvis contrast showed 6 × 7.5 cm presacral fluid collection.
Abstract Background Enhancer of zeste homologue 2 (EZH2), the catalytic subunit histone lysine methyltransferase Polycomb Repressor Complex (PRC2), mediates gene silencing target genes epigenetically. It is over-expressed and associated with poor outcomes in numerous malignancies. EZH2 inhibitors are currently used treatment follicular lymphomas epithelioid sarcomas. Oesophageal adenocarcinoma (OAC) has predicted sensitivity to inhibition due high prevalence potentially sensitizing...
Abstract Introduction Colorectal surgery under ERAS reduces postoperative morbidity by 40-50% and shortens length of hospital stay 2-3 days. The 2018 National Bowel Cancer Audit reported a 30-day readmission rate 10.5% for colorectal 90-day mortality 2% nationally. Evidence shows rates increase with discharge C-reactive protein (CRP); 16.5% when CRP &gt;100 mg/L 6% &lt;100 mg/L. Method Data was collected prospectively at small island DGH on 89 patients from September - March 2020....