A5008258452- Liver Disease and Transplantation
- Palliative Care and End-of-Life Issues
- Liver Disease Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Geriatric Care and Nursing Homes
- Organ Transplantation Techniques and Outcomes
- Innovations in Medical Education
- Cancer survivorship and care
- Medical Education and Admissions
- Diversity and Career in Medicine
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis C virus research
- Economic and Financial Impacts of Cancer
- Optimism, Hope, and Well-being
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
- Healthcare professionals’ stress and burnout
- Family and Patient Care in Intensive Care Units
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- COVID-19 and healthcare impacts
- Enhanced Recovery After Surgery
- Hepatitis B Virus Studies
- Social Media in Health Education
Massachusetts General Hospital
2014-2025
Harvard University
2014-2025
NYU Langone Health
2024
Cedars-Sinai Medical Center
2024
University Hospitals Sussex NHS Foundation Trust
2023
Brighton and Sussex Medical School
2023
Department of Health and Social Care
2023
Brigham and Women's Hospital
2022
European Foundation for the Study of Chronic Liver Failure
2021
Washington University in St. Louis
2009-2014
•Patients with cirrhosis experience high rates of hepatic decompensation and death following SARS-CoV-2 infection.•Mortality increased in stepwise fashion according to Child-Pugh class.•Other risk factors for included advancing age alcohol-related liver disease.•Mortality was higher patients advanced than propensity-score-matched controls without disease.•The majority deaths were from COVID-19-related lung disease. Background & AimsChronic disease (CLD) are associated immune dysregulation,...
Despite concerns that patients with liver transplants might be at increased risk of adverse outcomes from COVID-19 because coexisting comorbidities and use immunosuppressants, the effect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on this patient group remains unclear. We aimed to assess clinical in these patients. In multicentre cohort study, we collected data laboratory-confirmed SARS-CoV-2 infection, who were older than 18 years, had previously received a...
Palliative care is defined as multidisciplinary, specialized medical that addresses the physical, spiritual, and psychosocial needs of patients with serious illness their caregivers.[1, 2] The benefits palliative are increasingly recognized across disease states for decompensated cirrhosis (DC).[3-5] This American Association Study Liver Diseases (AASLD) guidance to providing was developed support oversight AASLD Practice Guidelines Committee. Committee chose commission a guidance, rather...
Background: Health care–related transportation insecurity (delayed or forgone medical care due to barriers) is being increasingly recognized as a social risk factor affecting health outcomes. We estimated the national burden and adverse outcomes of among US adults with chronic liver disease (CLD). Methods: Using U.S. National Interview Survey from 2014 2018, we identified self-reported CLD. used complex weighted survey analysis obtain estimates insecurity. examined associations between...
Hepatitis C virus infection is common in patients with CKD and leads to accelerated progression ESRD. Sofosbuvir a potent direct-acting antiviral therapy against hepatitis virus; however, there are concerns about its safety CKD. The objective of our study was determine the efficacy sofosbuvir CKD.We studied retrospective observational cohort defined by eGFR<60 ml/min per 1.73 m2, ≥30 mg albuminuria 1 g creatinine, or ≥200 proteinuria creatinine who received sofosbuvir-based large health care...
Sofosbuvir-based direct-acting antiviral therapy revolutionized the treatment of hepatitis C virus (HCV) infection. However, sofosbuvir use is not approved for patients with severe renal insufficiency (estimated glomerular filtration (eGFR) rate below 30 ml/min) or end-stage disease (ESRD) based on concerns raised during premarket animal testing over hepatobiliary and cardiovascular toxicity in this population. We report first published data sofosbuvir-based regimens ESRD, focusing clinical...
To assess the association between internal medicine (IM) residents' race/ethnicity and clinical performance assessments.The authors conducted a cross-sectional analysis of assessment scores at 6 U.S. IM residency programs from 2016 to 2017. Residents underrepresented in (URiM) were identified using self-reported race/ethnicity. Standardized calculated for Accreditation Council Graduate Medical Education core competencies. Cross-classified mixed-effects regression assessed competency scores,...
The financial impact of liver transplantation has been underexplored. We aimed to identify associations between high burden (≥10% annual income spent on out-of-pocket medical costs) and work productivity, distress (coping behaviors in response the burden), toxicity (health-related quality life, HRQOL) among adult recipients transplant. Between June 2021 May 2022, we surveyed 207 transplant across 5 US centers. Financial were measured by 25 items adapted from national surveys cancer...
Background: While there is a growing need for interventions addressing symptom burden in patients with decompensated cirrhosis (DC), the lack of validated assessment tools critical barrier. We investigated psychometric properties revised Edmonton Symptom Assessment System (ESAS-r) longitudinal cohort DC. Methods: Adult outpatients DC were prospectively recruited from liver transplant center and completed ESAS-r at baseline week 12. examined reliability, floor/ceiling effects, structural...
Adherence to the American Association for Study of Liver Disease (AASLD) guidelines management chronic hepatitis B (CHB) has not been systematically assessed. We sought comprehensively evaluate adherence five key areas these guidelines. also evaluated physician and patient factors underlying nonadherence, predictors nonadherence such as type, demographic factors, phase CHB infection.Nine hundred sixty-two adult patients were retrospectively identified. Each chart was reviewed in detail. The...
Specialty palliative care (PC) is underused for patients with end‐stage liver disease (ESLD). We sought to examine attitudes of hepatologists and gastroenterologists about PC ESLD. conducted a cross‐sectional survey these specialists who provide Participants were recruited from the American Association Study Liver Diseases membership directory. Using questionnaire adapted prior studies, we examined physicians’ whether varied based on patients’ candidacy transplantation. identified predictors...
<h3>Importance</h3> Gender bias may affect assessment in competency-based medical education. <h3>Objective</h3> To evaluate the association of gender with internal medicine residents. <h3>Design, Setting, and Participants</h3> This multisite, retrospective, cross-sectional study included 6 residency programs United States. Data were collected from July 1, 2016, to June 30, 2017, analyzed 7 November 6, 2019. <h3>Exposures</h3> Faculty assessments resident performance during general inpatient...
Background: Symptom-focused trials are critically needed for patients with cirrhosis. However, this work would benefit from standard processes and validated measures. Methods: A writing group was formed among hepatologists, nurses, palliative care providers, pharmacists, clinical trial experts focused on symptom management in cirrhosis to define the key (1) components of design, (2) targets, (3) measurement, (4) outcomes each target. From July 2022 January 2023, panelists participated an...
Hematopoietic stem cell transplantation (HCT) is an intensive and potentially curative therapy for patients with hematologic malignancies. Patients admitted HCT experience a prolonged, isolating hospitalization endure substantial physical psychological symptoms. However, there paucity of research on the impact post-traumatic stress disorder (PTSD) symptoms in transplant recipients. This secondary analysis 250 who underwent autologous allogeneic examined PTSD using Checklist-Civilian measured...