A5018016311- Adipose Tissue and Metabolism
- Renal function and acid-base balance
- Sepsis Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease and Transplantation
- Cardiovascular Disease and Adiposity
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hydrocarbon exploration and reservoir analysis
- Fatty Acid Research and Health
- Diet and metabolism studies
- Pneumothorax, Barotrauma, Emphysema
- Venous Thromboembolism Diagnosis and Management
- Case Reports on Hematomas
- Biotechnology and Related Fields
- Occupational and environmental lung diseases
- Hemodynamic Monitoring and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Cholesterol and Lipid Metabolism
- Hematological disorders and diagnostics
- Immune Cell Function and Interaction
- Lipid metabolism and biosynthesis
- Evolution and Paleontology Studies
- Alcoholism and Thiamine Deficiency
- Vitamin D Research Studies
- Geological Studies and Exploration
Mayo Clinic
2022-2024
Mayo Clinic in Arizona
2023
St. Luke's Hospital
2022
University of Missouri
2014-2019
University of Illinois Urbana-Champaign
1985-2016
University of Florida
2013
Harvard University
2012
Brigham and Women's Hospital
2012
VA Boston Healthcare System
2012
Newcastle University
1996
Cardiometabolic impairments that begin early in life are particularly critical, because they often predict metabolic dysfunction adulthood. Obesity, high-fat diet (HFD), and inactivity all associated with adipose tissue (AT) inflammation insulin resistance (IR), major predictors of dysfunction. Recent evidence has also the gut microbiome cardiometabolic health.
Objective The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because its size and susceptibility to atherosclerosis, among other characteristics. relationship between adipose tissue inflammation metabolic dysfunction in this was investigated here. Methods Young female pigs were fed a Western‐style high‐fat diet (HFD) ( n = 4) or control low‐fat (LFD) for period 9 months compared outcomes inflammation. Results HFD‐fed “OBESE” 2.5 times heavier P < 0.001)...
Background: The Sepsis-3 guidelines have incorporated serum lactate levels of >2 mmol/L in septic shock definition to account for higher observed mortality. Further evidence is needed support this threshold cirrhosis, as well target mean arterial pressure (MAP) during resuscitation. Methods: This observational cohort study investigated the association between initial and resuscitation MAP on in-hospital mortality patients with without cirrhosis. Patients admitted intensive care unit...
The eosinophilia-myalgia syndrome (EMS) is a recently described disease that has been associated with the ingestion of L-tryptophan containing trace amounts several impurities. first such contaminant to be identified and linked epidemiologically EMS epidemic was 1,1'-ethylidenebis(L-tryptophan) (EBT), but its role in etiology pathogenesis controversial. We report development inflammation fibrosis affecting dermis subcutis, including fascia perimyseal tissues, after daily intraperitoneal...
The precise site of intestinal permeability changes in patients with coeliac and inflammatory bowel disease is unknown.To design a non-invasive technique for the localisation altered gastrointestinal to 51chromium labelled EDTA (51CrEDTA). method depends on comparing defining concentration/time profiles serum series simultaneously ingested indicators well defined absorption (3-0-methyl-D-glucose (jejunal indicator), 57cobalt vitamin B12 (ileal sulphasalazine (caecal-colonic indicator))...
Lipocortin-1 (LC-1; annexin-1) may mediate some anti-inflammatory actions of the glucocorticoids, probably after binding to specific cell surface sites. We have quantified LC-1 levels in bronchoalveolar lavage (BAL) fluid and cells collected from seven healthy volunteers before 7 days treatment with an oral glucocorticoid, prednisolone (30 mg/day). Extracellular BAL was higher cellular lower than [extracellular: before, median 98 ng/mg albumin (range 48–350 albumin); after, 236 (19–414 P...
"Non-compressible" torso hemorrhage (NCTH) is the leading cause of preventable battlefield death, requiring rapid surgical or radiological intervention, which essentially precluded close to point injury. UK Joint Theatre Trauma Registry (JTTR) analysis 2002-2012 showed 85.5% NCTH mortality. JTTR vascular injury data 2003-2008 revealed 100% mortality in named truncal vessel injuries. Gas insufflation and hyper-pressure intraperitoneal fluid animal studies have demonstrated significant...
The storage of red blood cells (RBC) results in increased concentrations plasma free hemoglobin, potassium, glucose, and lactate, among other undesirable substances. These continue to increase as RBC products age can cause deleterious effects the patient. In setting cardiac surgery, autotransfusion devices are routinely used wash that is shed from surgical site. could also be stored units obtained bank. objective this study was compare product created by washing a unit RBCs with AutoLog...
Background. The contribution of ethanol ([EtOH]) to the osmol gap (OG) is commonly described by formula [EtOH (mg/dL)]/k, where k assumed be 4.6 (one-tenth its molecular weight) if behaves ideally in solution. However, several studies on convenience samples patients suggest that does not behave and may significantly different from this ideal constant. Objectives. To determine prospectively relationship between serum concentration total osmolality a group healthy volunteers. Methods....
Endothelin-1 (ET-1) is a potent vasoconstrictor and proinflammatory peptide that upregulated in obesity. Herein, we tested the hypothesis ET-1 signaling promotes visceral adipose tissue (AT) inflammation disrupts glucose homeostasis. We also if reduced required mechanism by which exercise ameliorates AT improves glycemic control found 1) diet-induced obesity, inflammation, dysregulation were not accompanied significantly increased levels of or circulation wild-type mice endothelial...
Plasma lipids obtained from swine which had been fed butter or margarine at two dietary magnesium (Mg) levels indicated that the level of Mg was more significant to plasma total cholesterol (TC), low-density lipoprotein (LDL-C) and high-density (HDL-C) than presence margarine. At 270 mg Mg/kg, is considered adequate for swine, there a difference in TC between those butterfat (105 126 %, respectively). LDL-C higher (88 71 In an additional 247 however, no butter. Although Mg/kg HDL-C butter,...
Abstract The aim of this study was to investigate the effect oxysterol 5α‐cholestane‐3β, 5, 6β‐triol (triol) on metabolism linoleic acid (18∶2n−6) arachidonic (20∶4n−6) and cell membrane fatty composition. Porcine kidney cells were incubated in medium with or without 10 μg/mL triol for 24 h, then 1, 6, 12 h a which contained 50 μM either [ 14 C]linoleic unlabeled acid. cellular uptake C] significantly higher triol‐treated than control cells. After 1‐ 6‐h incubations despite increase pool...
To study the anti-inflammatory mechanisms of glucocorticoids, we have compared effects intratracheal carrageenin (2.5 mg) on control rats and those in which inflammation was subdued by prior dexamethasone treatment (10 mg/l drinking water). Inflammation maximal 48 h post-carrageenin. After dexamethasone, caused tittle or oedema (wet lung (mg), n = 6, mean +/- S.E.M.; control, 995 51; + 1144 83; with alone, 1881 198), but had more lavage neutrophils than given alone (PMN x 10(6) /lung, 0.055...
Although aggressive research strides have been made to better understand the relationships between adipose tissue (AT) inflammation and metabolic disease, vast majority of work has done using rodents. The pig more closely models human thus is emerging as an attractive obesity model. Macrophage (Mφ) T cell infiltration into visceral AT (VAT) predictive dysfunction in rodents, but relationship VAT function not clear. We investigated how 9 months western diet (WD; high fat, fructose corn syrup,...
Neophytou, Andreas; Hart, Jaime; Cavallari, Jennifer; Smith, Thomas; Garshick, Eric; Laden, Francine Author Information