A5065588757- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Acute Kidney Injury Research
- Drug-Induced Hepatotoxicity and Protection
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Electrolyte and hormonal disorders
- Healthcare Policy and Management
- Heart Failure Treatment and Management
- Muscle and Compartmental Disorders
- Chronic Kidney Disease and Diabetes
- Takotsubo Cardiomyopathy and Associated Phenomena
- Artificial Intelligence in Healthcare
- Hepatitis Viruses Studies and Epidemiology
- Kidney Stones and Urolithiasis Treatments
- Folate and B Vitamins Research
- Health Literacy and Information Accessibility
- Pharmaceutical Practices and Patient Outcomes
- Alcoholism and Thiamine Deficiency
- Gallbladder and Bile Duct Disorders
- Global Cancer Incidence and Screening
Baylor College of Medicine
2023-2025
Michael E. DeBakey VA Medical Center
2023-2025
Baylor University
2023-2025
Indiana University School of Medicine
2019-2024
Indiana University – Purdue University Indianapolis
2019-2024
Indiana University
2020-2023
University School
2022-2023
Loma Linda University Health Care
2022
Virginia Commonwealth University
2013-2018
Hunter Holmes McGuire VA Medical Center
2014-2018
Despite the high prevalence of covert hepatic encephalopathy (CHE) in cirrhotics without previous overt HE (OHE), its independent impact on predicting clinically relevant outcomes is unclear. The aim this study was to define CHE time OHE, hospitalization, and death/transplant prospectively followed up patients OHE.Outpatient OHE were enrolled administered a standard paper-pencil cognitive battery for diagnosis. They systematically first development, hospitalization (liver-related/unrelated),...
Objectives: Diagnosing minimal hepatic encephalopathy (MHE) is challenging, and point-of-care tests are needed. Stroop EncephalApp has been validated for MHE diagnosis in single-center studies. The objective of the study was to validate a multicenter study. Methods: Outpatient cirrhotics (with/without prior overt (OHE)) controls from three sites (Virginia (VA), Ohio (OH), Arkansas (AR)) underwent two gold standards, psychometric score (PHES) inhibitory control test (ICT)....
Abstract Background & Aims Readmissions are a major burden in cirrhosis. A proportion of readmissions cirrhosis, especially because hepatic encephalopathy ( HE ) could be avoided through patient and caregiver engagement. We aimed to define the feasibility using Patient Buddy App its impact on 30‐day by engaging educating cirrhotic inpatients caregivers pilot study. Methods Cirrhotic with were enrolled followed for 30 days post‐discharge. On separately assigned devices loaded Buddy, they...
<h3>Importance</h3> Changes in the characteristics of patients with cirrhosis are likely to affect future outcomes and important understand planning for care this population. <h3>Objective</h3> To identify changes demographic clinical newly diagnosed cirrhosis. <h3>Design, Setting, Participants</h3> A retrospective cohort study a new diagnosis was conducted using Indiana Network Patient Care, large statewide regional health information exchange, between 2004 2014. Patients at least 1 year...
Background Liver transplantation (LT) is the final step in a complex care cascade. Little known about how race, gender, rural versus urban residence, or neighborhood socioeconomic indicators impact patient's likelihood of LT waitlisting risk death during evaluation. Methods We performed retrospective cohort study adults referred for to Indiana University Academic Medical Center from 2011 through 2018. Neighborhood status (SES) were obtained by linking patients addresses their census tract...
Mortality is high for severe alcohol-associated hepatitis (AH). Corticosteroids are the standard of care patients without contraindications. Recent data showed that interleukin-1β receptor antagonist anakinra attenuated inflammation and liver damage. We designed a multicenter, double-blind, randomized controlled trial to assess safety efficacy compared prednisone.
In non-alcoholic fatty liver disease, presence of fibrosis is predictive long-term liver-related complications. Currently, there are no reliable and non-invasive means quantifying in those with disease. Therefore, we aimed to evaluate the performance a panel models predicting disease.The accuracy FibroMeter 4 four other biopsy proven disease was compared. These were constructed post hoc patients who had necessary clinical information collected within 2 months biopsy. The areas under receiver...
Current approaches to determine the cause of acute kidney injury (AKI) in patients with cirrhosis are suboptimal. The aim this study was utility fractional excretion urea (FEUrea) for differential diagnosis AKI cirrhosis. A retrospective analysis performed (n = 50) and ascites admitted AKI. Using adjudicated etiology assessment as reference standard, receiver operating curves optimal cutoff, sensitivity (Sn), specificity (Sp) prerenal azotemia (PRA), type 1 hepatorenal syndrome (HRS),...
Despite the release of a growing number direct-acting antivirals and evolving policy landscape, many those diagnosed with hepatitis C virus (HCV) have not received treatment. Those from vulnerable populations are at particular risk being unable to access treatment, threatening World Health Organization (WHO) HCV elimination goals. The aim this study was understand association between approvals, HCV-related changes treatment in Indiana, explore by race, birth cohort insurance type. We...
The social determinants of health can pose barriers to accessing cancer screening and treatment have been associated with mortality. However, it is not clear whether area deprivation independently mortality in HCC cholangiocarcinoma when controlling for individual-level health.The cohort included individuals over 18 years old diagnosed (N=3460) or (N=781) reported the Indiana State Cancer Registry from 2009 2017. Area disadvantage was measured using index (SDI). SDI obtained by linking...
Importance Patients with decompensated cirrhosis are hospitalized for acute management temporizing and lifesaving procedures. Published data to inform intervention development in this area more than a decade old, it is not clear whether there have been improvements disparities the receipt of these procedures over time. Objective To evaluate associations race ethnicity treat time US. Design, Setting, Participants This retrospective cross-sectional study analyzed National Inpatient Sample on...
<h3>Importance</h3> Millions of Americans gained insurance through the state expansion Medicaid, but several states with large populations racial/ethnic minorities did not expand their programs. <h3>Objective</h3> To investigate implications Medicaid for liver transplant (LT) wait-listing trends minorities. <h3>Design, Setting, and Participants</h3> A cohort study was performed adults wait-listed LT using United Network Organ Sharing database between January 1, 2010, December 31, 2017....
Uromodulin [Tamm-Horsfall protein (THP)] is a glycoprotein uniquely produced in the kidney. It released by cells of thick ascending limbs apically urine and basolaterally renal interstitium systemic circulation. Processing mature urinary THP, which polymerizes into supramolecular filaments, requires cleavage an external hydrophobic patch (EHP) at COOH-terminus. However, THP circulation not polymerized, it remains unclear if nonaggregated forms exist natively urine. We propose that...