A5056797693- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Nutrition and Health in Aging
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Inhalation and Respiratory Drug Delivery
- COVID-19 and healthcare impacts
- High Altitude and Hypoxia
- Long-Term Effects of COVID-19
- Pleural and Pulmonary Diseases
- Cancer, Hypoxia, and Metabolism
- Frailty in Older Adults
- Mitochondrial Function and Pathology
- Protease and Inhibitor Mechanisms
- Dysphagia Assessment and Management
- Clinical Nutrition and Gastroenterology
- Obstructive Sleep Apnea Research
- Chronic Disease Management Strategies
- Antifungal resistance and susceptibility
- Muscle metabolism and nutrition
- Blood Coagulation and Thrombosis Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
Cleveland Clinic
2019-2025
Cleveland Clinic Lerner College of Medicine
2019-2025
Saint Joseph University
2021
European Society of Intensive Care Medicine
2020
University Hospitals of Cleveland
2015-2017
Case Western Reserve University
2016
Pulmonary and Critical Care Associates
2015
Louis Stokes Cleveland VA Medical Center
2015
Western Michigan University
2013-2014
Amway (United States)
2014
Background: COPD is a heterogeneous disorder. We developed multidisciplinary evaluation scheme to identify patients with who may benefit from phenotype-specific therapy. Methods: Our team of general and interventional pulmonologists, thoracic surgeons, radiologists, respiratory therapists, advanced practice nurses meets monthly discuss COPD. For each patient, pulmonary function tests, imaging, other pertinent data are reviewed. Emphysema assessed visually by quantitative computed tomography...
Bullous pemphigoid is a cutaneous autoimmune blistering disorder. The etiology for what precipitates this disease not entirely clear at point, although it has been associated with certain medications.We describe the case of 70-year-old male past medical history diabetes type 2 who developed diffuse eruption bullae skin biopsy positive bullous pemphigoid. He had previously prescribed sitagliptin 50 mg daily least one year prior to onset his disease. medication was discontinued and patient...
We sought to determine whether COPD conferred a higher risk for healthcare utilization in terms of hospitalization and clinical outcomes due COVID-19.
Abstract Perturbed metabolism of ammonia, an endogenous cytotoxin, causes mitochondrial dysfunction, reduced NAD + /NADH (redox) ratio, and postmitotic senescence. Sirtuins are ‐dependent deacetylases that delay In multiomics analyses, sirtuin pathways enriched during hyperammonemia. Consistently, Sirtuin3 (Sirt3) expression deacetylase activity were decreased, protein acetylation was increased in human murine skeletal muscle/myotubes. Global acetylomics subcellular fractions from myotubes...
ABSTRACT Background and objective COPD is the third most common cause of death worldwide fourth in United States. In hospitalized patients with COPD, mortality, morbidity healthcare resource utilization are high. Skeletal muscle loss frequent COPD. However, impact on adverse outcomes has not been systematically evaluated. We tested hypothesis that for exacerbation with, compared to those without, a secondary diagnosis phenotype (all ICD‐9 codes associated including cachexia) will have higher...
Signaling and metabolic perturbations contribute to dysregulated skeletal muscle protein homeostasis secondary sarcopenia in response a number of cellular stressors including ethanol exposure. Using an innovative multiomics-based curating unbiased data, we identified molecular therapeutic targets experimentally validated restoration ethanol-fed mouse model liver disease.Studies were performed ethanol-treated differentiated C2C12 myotubes physiological relevance established alcohol-related...
Patients with COPD have an increased risk for severe COVID-19. Symptoms such as high-grade fever, anorexia, and myalgia may distinguish COVID-19 from dyspnea due to a COPD-related exacerbation. Management of in the patient still warrant standard-of-care exacerbation treatment antimicrobial agents corticosteroids. Modalities treat acute respiratory failure can be used some caveats. infection who their illness at home should self-isolate, use nebulizers precautions avoid viral aerosolization,...
Abstract Objectives Skeletal muscle loss or sarcopenia is a frequent complication in heart failure (HF) and contributes to adverse clinical outcomes. We evaluated if age (primary) chronic disease (secondary) related sarcopenia, that we refer as compound impacts outcomes hospitalized patients with HF. Design Cross‐sectional study using patient data. Setting Data from the Agency for Healthcare Research Quality through Cost Utilization Project (HCUP). Participants Hospitalized adult primary...
Sites of entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly expressed in nasal epithelial cells; however, little is known about the impact intranasal corticosteroids (INCS) on disease 2019 (COVID-19)-related outcomes.
Ammonia is a cytotoxic metabolite with pleiotropic molecular and metabolic effects, including senescence induction. During dysregulated ammonia metabolism, which occurs in chronic diseases, skeletal muscle becomes major organ for nonhepatocyte uptake. Muscle disposal mitochondria via cataplerosis of critical intermediary α-ketoglutarate, senescence-ameliorating molecule. Untargeted mitochondrially targeted data were analyzed by multiomics approaches. These analyses validated experimentally...
Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD) patients, associated with skeletal muscle loss or sarcopenia, contributes to adverse clinical outcomes. In COPD, we have defined this as prolonged intermittent hypoxia (PIH) because the duration of occurs through sleep followed by normoxia during day, contrast recurrent brief hypoxic episodes apnoea (OSA). Adaptive cellular responses PIH are not known. Responses induced three cycles 8 h 16 were compared...
Sarcopenia, or loss of skeletal muscle mass and decreased contractile strength, contributes to morbidity mortality in patients with chronic obstructive pulmonary disease (COPD). The severity sarcopenia COPD is variable, there are limited data explain phenotype heterogeneity. Others have shown that several hallmarks cellular senescence, a potential mechanism primary (age-related) sarcopenia. We tested if genetic contributors the variability sarcopenic accelerated senescence COPD.
Introduction The effect of electronic inhaler monitoring (EIM) on healthcare utilization in chronic obstructive pulmonary disease (COPD) has not been studied. We hypothesized that the use EIM conjunction with a management program reduces patients COPD. Methods This is retrospective pre- and post-analysis quality improvement project. Patients COPD high (≥one hospitalization or emergency room visit during year prior to enrolment) were provided devices for controller rescue one year. contacted...
There are limited data on outcomes of older patients with chronic diseases. Skeletal muscle loss aging (primary sarcopenia) has been extensively studied but the impact secondary sarcopenia disease is not as well evaluated. Older diseases have both primary and that we term compound sarcopenia. We evaluated clinical in hospitalized cirrhosis given increasing number high prevalence these patients. The Nationwide Inpatients Sample (NIS) database (years 2010-2014) was analyzed to study cirrhosis....
Inhaled Corticosteroids (ICS) are commonly prescribed to patients with severe COPD and recurrent exacerbations. It is not known what impact ICS cause in terms of COVID-19 positivity or disease severity COPD. This study examined 27,810 from the Cleveland Clinic registry between March 8th September 16th, 2020. Electronic health records were used determine diagnosis COPD, use, clinical outcomes. Multivariate logistic regression was adjust for demographics, month testing, comorbidities be...
Rationale: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Our previous studies have identified that nocturnal hypoxemia causes skeletal muscle loss (i.e., sarcopenia) in vitro models COPD. Objectives: We aimed to extend our preclinical mechanistic findings by analyzing a large sleep registry determine whether associated with sarcopenia patients Methods: Sleep from COPD (n = 479) and control subjects without 275) were analyzed. Patients apnea, as...
Abstract Background Asthma, a chronic inflammatory airway disorder, can increase the risk of hospitalizations in individuals with viral infections such as COVID-19. The impact COVID-19 pandemic on asthma-related United States remains unknown. Objective We hypothesized that led to an economic burden society and decrease hospitalization rates for asthma. Methods analyzed weighted data from National Inpatient Sample (NIS) between January 1, 2018, December 31, 2020. outcomes were asthma rates,...