A5072818219- Sepsis Diagnosis and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Intensive Care Unit Cognitive Disorders
- Acute Kidney Injury Research
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Patient Safety and Medication Errors
- Cardiac, Anesthesia and Surgical Outcomes
- Innovations in Medical Education
- Health Sciences Research and Education
- Bacterial Identification and Susceptibility Testing
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Vitamin C and Antioxidants Research
- Hemodynamic Monitoring and Therapy
- Pharmaceutical studies and practices
- Anesthesia and Neurotoxicity Research
- Antibiotic Use and Resistance
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Alcoholism and Thiamine Deficiency
- Healthcare cost, quality, practices
University of Kentucky
2016-2025
University of Kentucky HealthCare
2015-2024
American College of Clinical Pharmacy
2024
National Heart Lung and Blood Institute
2023
Portola Pharmaceuticals (United States)
2019
Advisory Board Company (United States)
2019
West Virginia University
2019
University of Arkansas for Medical Sciences
2017
Albert B. Chandler Hospital
2017
Medical University of South Carolina
2012
Abstract The American College of Clinical Pharmacy (ACCP) Pharmacotherapy Didactic Curriculum Toolkit has been used by colleges and schools pharmacy as a guide for curricular development revisions since its inaugural publication in 2009. toolkit was last revised updated the 2019 Publications Committee. 2023 ACCP Committee charged with reviewing Update to determine any necessary revisions/updates. committee tier classifications, shifting focus content within Pharm.D. curriculum. Multiple...
Mounting evidence has shown that critically ill patients are commonly thiamine deficient. We sought to test the hypothesis with septic shock exposed would demonstrate improved lactate clearance and more favorable clinical outcomes compared those not receiving thiamine.Retrospective, single-center, matched cohort study.Tertiary care academic medical center.Adult admitted an International Classification of Diseases, 9th Edition, or 10th diagnosis code either medicine surgery ICU.None.Patients...
Abstract Introduction The American College of Clinical Pharmacy (ACCP) Pharmacotherapy Didactic Curriculum Toolkit was created by the 2008 ACCP Educational Affairs Committee to provide guidance schools and colleges pharmacy for didactic pharmacotherapy curricular development. toolkit revised updated 2016 Committee. Objectives In accordance with Board Regents decision update every 3 years, 2019 Publications charged updating guide adequate disease state inclusion depth coverage in curricula....
Abstract Objective Administration of diuretics has been shown to assist fluid management and improve clinical outcomes in the critically ill post-shock resolution. Current guidelines have not yet included standardization or guidance for diuretic-based de-resuscitation patients. This study aimed evaluate impact a multi-disciplinary protocol diuresis-guided ill. Methods was pre-post single-center pilot within medical intensive care unit (ICU) large academic center. Adult patients admitted...
Despite the established role of critical care pharmacist on ICU multiprofessional team, workloads are likely not optimized in ICU. Medication regimen complexity (as measured by Regimen Complexity-ICU [MRC-ICU] scoring tool) has been proposed as a potential metric to optimize workload but lacked robust external validation. The purpose this study was test hypothesis that MRC-ICU is related both patient outcomes and interventions diverse population.This multicenter, observational cohort...
Importance Individuals who survived COVID-19 often report persistent symptoms, disabilities, and financial consequences. However, national longitudinal estimates of symptom burden remain limited. Objective To measure the incidence changes over time in disability, status after COVID-19–related hospitalization. Design, Setting, Participants A US multicenter prospective cohort study with 1-, 3-, 6-month postdischarge visits was conducted at 44 sites participating National Heart, Lung, Blood...
A framework for evaluating pharmacists’ impact on cost avoidance in the intensive care unit ( ICU ) and emergency department ED has not been established. This scoping review was registered CRD 42018091217) conducted to identify, aggregate, qualitatively describe highest quality evidence generated by clinical pharmacists interventions performed an or . Searches were PubMed, Scopus, CINAHL , Cochrane Central Register of Controlled Trials, Database Systematic Reviews from inception until April...
To comprehensively classify interventions performed by emergency medicine clinical pharmacists and quantify cost avoidance generated through their accepted interventions.A multicenter, prospective, observational study was between August 2018 January 2019.Community academic hospitals in the United States.Emergency pharmacists.Recommendations classified into one of 38 intervention categories associated with avoidance.Eighty-eight at 49 centers 13,984 during 917 shifts that were on 8,602...
Sepsis-associated acute kidney injury often leads to disease (AKD), predisposing patients long-term complications such as chronic (CKD), failure with replacement therapy (KFRT), or mortality. Risk stratification of AKD represents an opportunity assist prognostication complications.Single-center retrospective cohort.6,290 critically ill admitted the intensive care unit severe sepsis septic shock. Patients were separated into cohorts based on incident not, and survivors identified who alive...
Abstract Background Preliminary studies have suggested that the renin-angiotensin system is activated in critical illness and associated with mortality kidney outcomes. We sought to assess a larger, multicenter study relationship between serum renin Major Adverse Kidney Events (MAKE) intensive care unit (ICU) patients. Methods Prospective, at two institutions of patients without acute injury (AKI). Blood samples were collected for measurement median 2 days into index ICU admission 5–7 later....
Introduction: Clinical pharmacists bring unparalleled medication expertise, but quantifying their impact on a health system’s bottom line remains unestablished. Objective: To classify interventions by with and without board certification quantify the cost avoidance (CA) from accepted interventions. Methods: This multicenter prospective observational study, conducted between August 2018 January 2019, included certified (BPS) non-board (Non-BPS) emergency medicine (EM) intensive care unit...
The definition of sepsis-associated acute kidney injury (SA-AKI) was updated in 2023. This study aims to describe the epidemiology SA-AKI using consensus and evaluate clinical outcomes. a retrospective cohort analysis conducted at two academic medical centers. Adult patients admitted intensive care units (ICU) between 2010 2022 were included categorized as SA-AKI, sepsis alone, or AKI alone. further classified by time onset (early < 2 days from diagnosis vs. late 2–7 following diagnosis)...
Although the potential dangers of hyperchloremia from resuscitation fluids continue to emerge, no study date has considered contribution medication diluents cumulative volume and hyperchloremia. This compares saline versus dextrose 5% in water as primary diluent occurrence critically ill patients.Prospective, open-label, sequential period pilot study.Medical ICU a large academic medical center.Adult patients admitted were eligible for inclusion. Patients who less than 48 hours, 18 years old,...
Consensus guidelines recommend targeting a vancomycin area under the curve to minimum inhibitory concentration (AUC24 :MIC) ratio of 400-600 improve therapeutic success and reduce nephrotoxicity. Although specify either Bayesian software or first-order equations may be used estimate AUC24 , there are currently no large studies directly comparing these methods.To compare calculated using with two-drug concentrations at steady state two- one-concentration estimations.This was single-center,...
The use of high-fidelity simulation training for preparing pharmacy residents various high-stress and high-impact medical emergencies the impact this on residents' perception preparedness are described.During 2015-16 residency year at University Kentucky Medical Center, training, in addition to lecture-based orientation was chosen as a method reinforce skills knowledge learned throughout orientation, before began working on-call shifts. Three different exercises were developed cover five...
The response of ICU patients to continuously infused ketamine when it is used for analgesia and/or sedation remains poorly established.To describe continuous infusion (CI) use in critically ill patients, including indications, dose and duration, adverse effects, patient outcomes, time goal pain/sedation score range, exposure analgesics/sedatives, delirium.Multicenter, retrospective, observational study from twenty-five diverse institutions the United States. Patients receiving CI between...
Due to the inconsistent correlation of vancomycin trough concentrations with 24-hour area under curve (AUC) and a desire reduce rates vancomycin-associated acute kidney injury, an institutional guideline was implemented by Antimicrobial Stewardship Team in September 2017 monitor using AUC. Three stages were utilized organize process: preparation, implementation, evaluation. The preparation stage used present literature key stakeholders, pharmacy meetings focused on development dosing...
Background: Limited data support high-dose oseltamivir in critically ill patients with influenza. In several recent influenza seasons, there were drug shortages. Methods: This was a retrospective cohort analysis of 57 admitted to the intensive care unit (ICU) confirmed Patients receiving compared those standard dosing. Results: When adjusted for clinically relevant predictors disease severity, including age, duration therapy, Acute Physiology and Chronic Health Evaluation II score, receipt...
Background: Sepsis and septic shock remain a significant burden on the US health care system. A multidisciplinary response system (Coordinated Response to Sepsis, CaRTS) that included pharmacist responder was implemented for patients with newly suspected sepsis. Objective: To evaluate time appropriate antibiotic administration among CaRTS intervention compared historical controls. Method: The an electronic order set as well activation of team pharmacy nursing personnel coordinate...