A5079970405- Air Quality and Health Impacts
- Climate Change and Health Impacts
- COVID-19 impact on air quality
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced organ toxicity mitigation
- Acute Kidney Injury Research
- Glioma Diagnosis and Treatment
- Economic and Environmental Valuation
- Error Correcting Code Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Health, Environment, Cognitive Aging
- Opinion Dynamics and Social Influence
- Pancreatitis Pathology and Treatment
- Environmental Justice and Health Disparities
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Angiogenesis and VEGF in Cancer
- Energy, Environment, Economic Growth
- Global Public Health Policies and Epidemiology
- Cooperative Communication and Network Coding
- Tuberous Sclerosis Complex Research
- Childhood Cancer Survivors' Quality of Life
- Cancer Immunotherapy and Biomarkers
- Nitric Oxide and Endothelin Effects
- Climate Change Policy and Economics
- Chemotherapy-induced cardiotoxicity and mitigation
Harvard University
2021-2025
To develop and externally validate a prediction model for severe cisplatin associated acute kidney injury (CP-AKI).
Vascular endothelial growth factor (VEGF) signaling pathway inhibitors (VSPIs) treat numerous types of cancers by blocking tumor angiogenesis,1 yet are associated with both hypertension and proteinuria. Hypertension is one the earliest on-target effects VSPIs has been reported in 20-90% patients.2,3 The onset can vary from hours to weeks, depending upon half-life VSPI.4 There several proposed mechanisms for VSPI-associated hypertension, including reduced vasodilatory nitric oxide...
The COVID-19 pandemic has induced large-scale behavioral changes, presenting a unique opportunity to study how air pollution is affected by societal shifts. At 455 PM
Pollution from coal-fired power plants has been linked to substantial health and mortality burdens in the US. In recent decades, federal regulatory policies have spurred efforts curb emissions through various actions, such as installation of control technologies on plants. However, assessing impacts these measures, particularly over longer periods time, is complicated by several factors. First, units that potentially receive intervention (power plants) are disjoint those which outcomes...
The substantial effect of air pollution on cardiovascular disease and mortality burdens is well-established. Emissions-reducing interventions coal-fired power plants -- a major source hazardous have proven to be an effective, but costly, strategy for reducing pollution-related health burdens. Targeting the that achieve maximum benefits while satisfying realistic cost constraints challenging. primary difficulty lies in quantifying intervening at particular plants. This further complicated...
Journal Article Accepted manuscript Effect of Mannitol on Cisplatin-Associated AKI: A Target Trial Emulation Get access Shruti Gupta, Gupta Division Renal Medicine, Brigham and Women's Hospital, Boston, MA, USAAdult Survivorship Program, Dana-Farber Cancer Institute, USAHarvard Medical School, USA Correspondence to: Gupta; E-mail: Sgupta21@bwh.harvard.edu https://orcid.org/0000-0002-5747-2151 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ilya G Glezerman,...
ABSTRACT The COVID-19 pandemic has induced large-scale social, economic, and behavioral changes, presenting a unique opportunity to study how air pollution is affected by unprecedented societal shifts. At each of 455 PM 2.5 monitoring sites across the United States, we conduct causal inference analysis determine impacts interventions changes (“lockdowns”) on concentrations. Our approach allows for rigorous confounding adjustment provides highly spatio-temporally resolved effect estimates. We...
Emissions generators, such as coal-fired power plants, are key contributors to air pollution and thus environmental policies reduce their emissions have been proposed. Furthermore, marginalized groups exposed disproportionately high levels of this heightened susceptibility its adverse health impacts. As a result, robust evaluations the heterogeneous impacts regulations justifying designing maximally protective interventions. However, complicated in that much regulatory policy intervenes on...
Short- and long-term changes in electricity generating unit (EGU) emissions were observed during COVID-19 public health interventions the United States. In a generalized synthetic control framework, we employ weekly EGU SO2, NOx, CO2 data from EPA's Clean Air Markets Database location-specific meteorology 2010 to 2019 estimate each EGU's hypothetical business as usual (BAU) throughout 2020. We find that over 60% (covering >50% of total generation) EGUs saw increases relative BAU, with most...
BACKGROUND AND AIM: Given the disproportionately high air pollution exposures experienced by marginalized population groups, robust evaluations of heterogeneous health impacts quality regulations are key to justifying and designing maximally protective future interventions. Such complicated two issues: 1) much regulatory policy is aimed at intervening on large emissions generators while resulting measured in populations exposed from these sources; 2) due transport, interventions one...