A5023209904- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Chronic Lymphocytic Leukemia Research
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Computational Drug Discovery Methods
- Infectious Disease Case Reports and Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related cognitive impairment studies
- Blood Pressure and Hypertension Studies
- Angiogenesis and VEGF in Cancer
- Frailty in Older Adults
- Bladder and Urothelial Cancer Treatments
- Nitric Oxide and Endothelin Effects
- Body Contouring and Surgery
- PARP inhibition in cancer therapy
- Diabetes Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Cardiac pacing and defibrillation studies
- COVID-19 Clinical Research Studies
- Cutaneous Melanoma Detection and Management
- Chemotherapy-induced organ toxicity mitigation
- Urinary Bladder and Prostate Research
- Advanced Breast Cancer Therapies
Massachusetts General Hospital
2022-2024
Harvard University
2022-2023
Importance Serum creatinine–based estimated glomerular filtration rate (eGFRcr) may overestimate the (GFR) in patients with cancer. Cystatin C–based eGFR (eGFRcys) is an alternative marker of GFR. Objective To determine whether therapeutic drug levels and adverse events (AEs) associated renally cleared medications were higher cancer whose eGFRcys was more than 30% lower their eGFRcr. Design, Setting, Participants This cohort study analyzed adult at 2 major academic centers Boston,...
Abstract Background Creatinine‐based estimated glomerular filtration rate (eGFR CRE ) may overestimate kidney function in patients with sarcopenia. While cystatin C‐based eGFR CYS is less affected by muscle mass, it underestimate obesity. We sought to evaluate the relationship between body composition defined computed tomography (CT) scans and discordance creatinine, adult cancer. Methods This study a cross‐sectional of consecutive adults cancer an abdominal CT scan performed within 90 days...
Abstract Cyclin-dependent kinase (CDK) 4/6 inhibitors have significantly improved overall and progression free survival of patients with metastatic breast cancer, but their effect on short long-term kidney function is unknown. We found that early, mild estimated glomerular filtration rate (eGFR) decline was common in treated CDK inhibitors; however, severe injury rare eGFR uncommon.
Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPi) have revolutionized the treatment of ovarian cancer; however, real-world data on kidney function among patients treated with PARPi are lacking. Methods We identified adults olaparib or niraparib between 2015 and 2021 at a major cancer center in Boston, MA, USA. determined incidence any acute injury (AKI), defined as least 1.5-fold rise serum creatinine from baseline first 12 months following initiation. calculated percentage...
Vascular endothelial growth factor (VEGF) signaling pathway inhibitors (VSPIs) treat numerous types of cancers by blocking tumor angiogenesis,1 yet are associated with both hypertension and proteinuria. Hypertension is one the earliest on-target effects VSPIs has been reported in 20-90% patients.2,3 The onset can vary from hours to weeks, depending upon half-life VSPI.4 There several proposed mechanisms for VSPI-associated hypertension, including reduced vasodilatory nitric oxide...
Key Points A large eGFR discordance ( i.e ., cystatin C–based >30% lower than creatinine-based eGFR) is common in older adults and increased with age. was associated risk of falls, hospitalization, death, independent kidney function. There are multiple ways to measure differences creatinine C; all produce similar associations aging-related adverse outcomes. Background calculated using C often differ adults. We hypothesized that (eGFRcys) values significantly (eGFRcr) may have higher...
Creatinine-based estimated glomerular filtration rate (eGFRCRE) may overestimate kidney function in patients with cancer. Cystatin C-based eGFR (eGFRCYS) is an alternative marker of function. We investigated whether discrepancy, defined as eGFRCYS >30% lower than the concurrent eGFRCRE, had increased risk adverse events resulting from renally-cleared medications.We conducted a cohort study adult cancer who serum creatinine and cystatin C measured on same day between May 2010 January 2022 at...
Background: Sodium–glucose transporter 2 (SGLT2) inhibitors have been approved for treatment of diabetes mellitus (DM), chronic kidney disease, and heart failure, but little is known about prescription levels safety profiles among people with HIV (PWH). Methods: We leveraged data from the US Mass General Brigham electronic healthcare database to determine use/uptake SGLT2 PWH type II (DM2) (with or without proteinuria, failure) assess rates adverse events DM2 taking inhibitors. Results:...
Abstract Antiviral medications such as remdesivir, molnupiravir, and nirmatrelvir/ritonavir are most effective when used early in the course of coronavirus disease 2019 (COVID-19). These mainly authorized for outpatient use high risk populations. End-stage kidney (ESKD) is among strongest factors mortality from COVID-19, however, therapeutic options have been lacking this patient population given exclusion ESKD registrational trials antiviral therapy leading to limited FDA approval. In our...
Introduction: Renal adverse events related to receptor tyrosine kinase inhibitors (RTKIs) have been reported, including elevated creatinine levels, electrolyte abnormalities, blood pressure, and proteinuria. Cabozantinib is a RTKI approved for patients with renal cell carcinoma (RCC), who failed other lines of treatment. Here we report case nephrotic syndrome biopsy-proven podocytopathy shortly after starting cabozantinib. Case description: An 80-year-old white man stage IV metastatic...
Abstract Purpose Creatinine-based estimated glomerular filtration rate (eGFR CRE ) may overestimate kidney function in patients with sarcopenia. While Cystatin C-based eGFR CYS is less affected by muscle mass, it underestimate obesity. We sought to evaluate the relationship between body composition and discrepancies creatinine cancer. Methods conducted a cross-sectional study of consecutive adults cancer who had an abdominal CT scan performed within 90 days simultaneous measurements May...
Radical cystectomy with urinary diversion, or without cisplatin-based neoadjuvant chemotherapy, is the current standard of care for nonmetastatic muscle invasive bladder cancer 1. Orthotopic ileal neobladder a type continent diversion that utilizes an intestinal segment as anatomical and functional substitution (Supplemental Figure 1). Compared to conduit, has advantage achieving spontaneous voiding continence.