Julie-Alexia Dias
A5065897031- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- BRCA gene mutations in cancer
- Pancreatitis Pathology and Treatment
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Acute Lymphoblastic Leukemia research
- Muscle metabolism and nutrition
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Childhood Cancer Survivors' Quality of Life
- Renal function and acid-base balance
Harvard University
2022-2025
Dana-Farber Cancer Institute
2023
Abstract Summary Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for special challenges studies admixed populations. Here, we present admix-kit, an integrated toolkit pipeline analyses Admix-kit implements a suite methods to facilitate genotype phenotype simulation,...
Abstract The increasing availability of diverse biobanks has enabled multi-ancestry genome-wide association studies (GWAS), enhancing the discovery genetic variants across traits and diseases. However, choice an optimal method remains debated due to challenges in statistical power differences ancestral groups approaches account for population structure. Two primary strategies exist: (1) Pooled analysis, which combines individuals from all backgrounds into a single dataset while adjusting...
Abstract Introduction: Breast cancer genome-wide association studies (GWAS) have identified over 200 susceptibility loci, many replicated in diverse populations. However, cross-ancestry evaluation of breast genetic architecture remains limited. We examined using GWAS summary results from European (EUR; cases (ca) = 188,474, controls (co) 96,201), East Asian (EAS; ca 20,393, co 86,329), African American (AA; 9,235, 10,184), and US Hispanic/Latina Latin (H/L; 2,396, =7,468) studies. Methods:...
Abstract Summary Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for special challenges study admixed populations. Here, we present admix-kit, an integrated toolkit pipeline analyses Admix-kit implements a suite methods to facilitate genotype phenotype simulation,...
Prostate cancer and its treatment may induce muscle wasting. Body composition functionality are rarely assessed in patients with prostate from developing countries due to the limited availability of high-quality equipment for routine diagnosis. This cross-sectional study evaluated association between several simplistic techniques assessing mass function a more complex standard reference wasting among Mexican men cancer. Muscle was highly prevalent, yet it presumably associated aging rather...
Many pathogenic sequence variants (PSVs) have been associated with increased risk of cancers. Mendelian prediction models use laws inheritance to predict the probability having a PSV based on family history, as well specified frequency and penetrance (agespecific developing cancer given genotype). Most existing assume is same for any PSVs in certain gene. However, some genes (for example, BRCA1/2), does vary by PSV. We propose an extension relax assumption that gene incorporating...