A5091964477- Chemotherapy-induced organ toxicity mitigation
- Acute Kidney Injury Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Radiation Dose and Imaging
- Acute Lymphoblastic Leukemia research
- Magnesium in Health and Disease
- Chronic Kidney Disease and Diabetes
- Tuberous Sclerosis Complex Research
- Occupational and environmental lung diseases
Brigham and Women's Hospital
2023-2024
BACKGROUND. Patients with cancer undergo frequent CT examinations iodinated contrast media and may be uniquely predisposed to contrast-associated acute kidney injury (CA-AKI).
To develop and externally validate a prediction model for severe cisplatin associated acute kidney injury (CP-AKI).
Abstract Introduction Hyperthermic intraoperative cisplatin (HIOC) is associated with acute kidney injury (AKI). Administration of high‐dose magnesium attenuates cisplatin‐induced AKI (CP‐AKI) in animal models but has not been rigorously examined humans. Methods We tested the feasibility and safety different doses mesothelioma patients receiving HIOC. In Pilot Study 1, we administered a 36‐h continuous infusion at 0.5 g/h, targeting serum levels between 3 4.8 mg/dL. 2A, 6 g bolus followed by...
Journal Article Accepted manuscript Effect of Mannitol on Cisplatin-Associated AKI: A Target Trial Emulation Get access Shruti Gupta, Gupta Division Renal Medicine, Brigham and Women's Hospital, Boston, MA, USAAdult Survivorship Program, Dana-Farber Cancer Institute, USAHarvard Medical School, USA Correspondence to: Gupta; E-mail: Sgupta21@bwh.harvard.edu https://orcid.org/0000-0002-5747-2151 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ilya G Glezerman,...