A5002019760- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Traumatic Brain Injury and Neurovascular Disturbances
- Nosocomial Infections in ICU
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Dialysis and Renal Disease Management
- Autoimmune Bullous Skin Diseases
- Venous Thromboembolism Diagnosis and Management
- Cancer Risks and Factors
- Heart Failure Treatment and Management
- Pressure Ulcer Prevention and Management
- Acute Kidney Injury Research
- Pharmacological Receptor Mechanisms and Effects
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Intensive Care Unit Cognitive Disorders
- Cassava research and cyanide
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Vitamin C and Antioxidants Research
- Renal Diseases and Glomerulopathies
- Patient Safety and Medication Errors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
Mayo Clinic Hospital
2020-2025
Regional Medical Center
2017
Massachusetts General Hospital
2017
Duquesne University
2015
Despite the established role of critical care pharmacist on ICU multiprofessional team, workloads are likely not optimized in ICU. Medication regimen complexity (as measured by Regimen Complexity-ICU [MRC-ICU] scoring tool) has been proposed as a potential metric to optimize workload but lacked robust external validation. The purpose this study was test hypothesis that MRC-ICU is related both patient outcomes and interventions diverse population.This multicenter, observational cohort...
Background Different equations for predicting body surface area have been derived. The DuBois and Mosteller are considered equivalent, but the accuracy in adult patients at extremes of height weight is unknown. Purpose To compare using both formulas to determine whether a difference affected chemotherapy dose. Methods Anthropometric data were extracted from 2012 Centers Disease Control Prevention Vital Health Statistics. Data males females examined. 50th percentiles used calculate with...
Refractory septic shock is associated with high morbidity and mortality. Hydroxocobalamin used to treat postoperative vasoplegia; however, data supporting its use in the setting of refractory limited restricted case reports. This study evaluates effect hydroxocobalamin on mean arterial pressure vasopressor requirements a series patients shock.Single-center, retrospective analysis.Urban, tertiary-care ICU.Adult ICU treated between August 2018 January 2020.Hydroxocobalamin 5 g IV...
Abstract Objective: To evaluate the rate of coinfections and secondary infections seen in hospitalized patients with COVID-19 antimicrobial prescribing patterns. Methods: This single-center, retrospective study included all aged ≥18 years admitted for at least 24 hours to a 280-bed, academic, tertiary-care hospital between March 1, 2020, August 31, 2020. Coinfections, infections, antimicrobials prescribed these were collected. Results: In total, 331 confirmed diagnosis evaluated. No...
Introduction: Monitoring unfractionated heparin (UFH) is challenging in the setting of mechanical circulatory support. Further complicating this are conditions that alter traditional coagulation tests. We present a case extreme hyperbilirubinemia managed with therapeutic plasma exchange (TPE) where anti- factor Xa (anti-Xa) assay and activated partial thromboplastin time (aPTT) were unreliable. Description: A 67-year-old female newly diagnosed hiatal hernia presented for elective...
Copyright © 2017 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
Copyright © 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
Abstract Background Inappropriate use of carbapenems is a major driver antimicrobial resistance. The intensive care unit (ICU) at Mayo Clinic Arizona had higher meropenem (MER) days therapy (DOT) per 1000 patient (PD) compared to other Enterprise sites, despite low rates Pseudomonal resistance narrower spectrum anti-pseudomonal beta-lactams. Methods A multidisciplinary team infectious diseases (ID) and critical medicine (CCM) physicians pharmacists was created reduce inappropriate MER in the...
1Mayo Clinic, Phoenix, AZ 2Mayo Clinic Alix School of Medicine, Scottsdale, 3Mayo
Introduction: Sedation for ventilated patients with COVID-19 is challenging given the severity and duration of disease. Complicating this introduction extracorporeal membrane oxygenation (ECMO) refractory respiratory failure. An ECMO circuit can meaningfully alter drug pharmacokinetics by sequestering drug, increasing volume distribution, altering clearance. Many common sedatives are known to be significantly impacted, thus standard dosing. In circumstances warranting deep sedation, such as...