Douglas A. Simonetto
A5056754182- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Organ Transplantation Techniques and Outcomes
- Telomeres, Telomerase, and Senescence
- Sepsis Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Electrolyte and hormonal disorders
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Artificial Intelligence in Healthcare
- LGBTQ Health, Identity, and Policy
- Acute Kidney Injury Research
- Substance Abuse Treatment and Outcomes
- Mesenchymal stem cell research
- Hepatitis Viruses Studies and Epidemiology
- Nutrition and Health in Aging
- Liver physiology and pathology
- Cytomegalovirus and herpesvirus research
- Cannabis and Cannabinoid Research
- Colorectal Cancer Screening and Detection
- Genetic and Kidney Cyst Diseases
- Renal function and acid-base balance
- Metabolism and Genetic Disorders
Mayo Clinic in Arizona
2016-2025
WinnMed
2015-2025
Mayo Clinic
2015-2025
Cedars-Sinai Medical Center
2024
Loma Linda University
2024
University of Southern California
2024
Mayo Clinic in Florida
2023
China Classification Society
2023
St. Luke's Hospital
2022
University of Minnesota Rochester
2021
The vasoconstrictor terlipressin is used for type 1 hepatorenal syndrome (HRS-1) in many parts of the world and part clinical practice guidelines Europe.We conducted a phase 3 trial to confirm efficacy safety plus albumin adults with HRS-1. patients were randomly assigned 2:1 ratio receive or placebo up 14 days; both groups, concomitant use was strongly recommended. primary end point verified reversal HRS, defined as two consecutive serum creatinine measurements 1.5 mg per deciliter less at...
Physiologic aging leads to attrition of telomeres and replicative senescence. An acceleration this process has been hypothesized in the progression chronic liver disease. We sought examine association telomere length (TL) with disease its impact on mortality risk. A cohort 7,072 adults leukocyte TL measurements from National Health Nutrition Examination Survey 1999‐2002 follow‐up through 2015 was analyzed. Liver defined by aminotransferase levels classified into etiology‐based advanced...
Background and Aims Interleukin‐22 has beneficial effects on inflammation impaired hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a recombinant fusion protein of human interleukin‐22 immunoglobulin G2 fragment crystallizable. This study aims to assess the safety efficacy signals in patients with moderate severe AH. Approach Results A phase‐2 dose‐escalating was carried out. (10 μg/kg, 30 or 45 μg/kg) administered days 1 7 tested 3 each (Model for End‐Stage...
Kaplan, David E.; Bosch, Jaime; Ripoll, Cristina; Thiele, Maja; Fortune, Brett Simonetto, Douglas A.; Garcia-Tsao, Guadalupe Author Information
The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between PHPs and consequences.
Chronic passive hepatic congestion (congestive hepatopathy) leads to fibrosis; however, the mechanisms involved in this process are not well understood. We developed a murine experimental model of congestive hepatopathy through partial ligation inferior vena cava (pIVCL). C57BL/6 and transgenic mice overexpressing tissue factor pathway inhibitor (SM22α‐TFPI) were subjected pIVCL or sham. Liver blood samples collected analyzed immunohistochemical, morphometric, real‐time polymerase chain...
Purpose To investigate the utility of magnetic resonance (MR) elastography-derived mechanical properties in discrimination hepatic inflammation and fibrosis early stages chronic liver diseases. Materials Methods All studies were approved by institutional animal care use committee. A total 187 animals studied, including 182 mice five pigs. These represented different diseases with a varying combination extent inflammation, fibrosis, congestion, portal hypertension. Multifrequency...
Nonalcoholic fatty liver disease (NAFLD) is currently one of most common forms chronic globally. NAFLD represents a wide spectrum involvement from nonprogressive isolated steatosis to nonalcoholic steatohepatitis (NASH), characterized by necroinflammation and fibrosis the top causes end-stage hepatocellular carcinoma. At present, there lack effective treatments, central barrier development therapies requirement for an invasive biopsy diagnosis NASH. Discovery reliable, noninvasive biomarkers...
Urinary neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in differentiating acute tubular necrosis (ATN) from other types of kidney injuries (AKIs) cirrhosis, particularly hepatorenal syndrome (HRS). However, NGAL is not currently available clinical practice North America.Urinary was measured a prospective cohort 213 US hospitalized patients with decompensated cirrhosis (161 AKI and 52 reference without AKI). assessed for its ability to discriminate ATN non-ATN predict...