A5037915962- Intensive Care Unit Cognitive Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Kidney Injury Research
- Pharmacological Effects and Toxicity Studies
- Long-Term Effects of COVID-19
- Hip and Femur Fractures
- Antimicrobial Resistance in Staphylococcus
- Cardiac, Anesthesia and Surgical Outcomes
- Innovations in Medical Education
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Pharmaceutical Practices and Patient Outcomes
- Antibiotic Use and Resistance
- Electrolyte and hormonal disorders
- Hemoglobinopathies and Related Disorders
- Poisoning and overdose treatments
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Intracranial Aneurysms: Treatment and Complications
- Patient Safety and Medication Errors
- Nutrition and Health in Aging
- Vitamin C and Antioxidants Research
- Health Systems, Economic Evaluations, Quality of Life
University of Kentucky
2016-2025
University of Kentucky HealthCare
2016-2025
National Heart Lung and Blood Institute
2023
EVERSANA (Canada)
2020-2022
Albert B. Chandler Hospital
2017-2022
Cornerstone Research Group (United States)
2013-2019
NYU Langone Health
2019
Baylor Scott & White Health
2019
Novartis (United Kingdom)
2019
Novartis (Switzerland)
2019
Mounting evidence has shown that critically ill patients are commonly thiamine deficient. We sought to test the hypothesis with septic shock exposed would demonstrate improved lactate clearance and more favorable clinical outcomes compared those not receiving thiamine.Retrospective, single-center, matched cohort study.Tertiary care academic medical center.Adult admitted an International Classification of Diseases, 9th Edition, or 10th diagnosis code either medicine surgery ICU.None.Patients...
Abstract Background Patients surviving critical illness develop muscle weakness and impairments in physical function; however, the relationship between early skeletal alterations function at hospital discharge remains unclear. The primary purpose of this study was to determine whether changes size, strength power assessed intensive care unit (ICU) predict discharge. Methods Study design is a single-center, prospective, observational patients admitted medicine or cardiothoracic ICU with...
Abstract Objective Administration of diuretics has been shown to assist fluid management and improve clinical outcomes in the critically ill post-shock resolution. Current guidelines have not yet included standardization or guidance for diuretic-based de-resuscitation patients. This study aimed evaluate impact a multi-disciplinary protocol diuresis-guided ill. Methods was pre-post single-center pilot within medical intensive care unit (ICU) large academic center. Adult patients admitted...
Abstract Background FDC is the first antibiotic with effluent flow rate-based dosing recommendations outlined in product label for patients receiving CRRT including modalities such as continuous venovenous hemodiafiltration (CVVHDF). The objective of this study was to investigate population pharmacokinetics among and validate these novel recommendations. Methods A multicenter pharmacokinetic critically ill conducted. Subsequent blood sampling performed at steady-state, concentrations were...
Although the potential dangers of hyperchloremia from resuscitation fluids continue to emerge, no study date has considered contribution medication diluents cumulative volume and hyperchloremia. This compares saline versus dextrose 5% in water as primary diluent occurrence critically ill patients.Prospective, open-label, sequential period pilot study.Medical ICU a large academic medical center.Adult patients admitted were eligible for inclusion. Patients who less than 48 hours, 18 years old,...
Hypophosphatemia is commonly observed in patients receiving continuous KRT. Patients who develop hypophosphatemia may be at risk of respiratory and neuromuscular dysfunction therefore subject to prolongation ventilator support. We evaluated the association phosphate-containing versus phosphate-free KRT solutions with dependence critically ill KRT.Our study was a single-center, retrospective, pre-post cohort adult mechanical ventilation during their intensive care unit stay. Zero-inflated...
Abstract Critically ill patients with requirement of continuous renal replacement therapy (CRRT) represent a growing intensive care unit (ICU) population. Optimal CRRT delivery demands communication between stakeholders, iterative adjustment therapy, and quality assurance systems. This Quality Improvement (QI) study reports the development, implementation outcomes system to support provision in ICU. was carried out at University Kentucky Medical Center September 2016 June 2019. We...
Postoperative ileus, a temporary cessation in bowel motility, is common and significant complication of major surgery. Consequences postoperative ileus include increased patient discomfort, delayed time to adequate nutrition, prolonged length stay, cost the healthcare system. The traditional, multi-modal approach resolution includes opioid minimization, early ambulation, feeding. Newer medications, such as methlynaltrexone alvimopan (which are peripherally acting mu receptor antagonists),...
The use of high-fidelity simulation training for preparing pharmacy residents various high-stress and high-impact medical emergencies the impact this on residents' perception preparedness are described.During 2015-16 residency year at University Kentucky Medical Center, training, in addition to lecture-based orientation was chosen as a method reinforce skills knowledge learned throughout orientation, before began working on-call shifts. Three different exercises were developed cover five...
Evidence‐based management of analgesia and sedation in COVID‐19‐associated acute respiratory distress syndrome remains limited. Non‐guideline recommended analgesic sedative medication regimens deeper targets have been employed for patients with COVID‐19 due to exaggerated requirements extended durations mechanical ventilation. This, coupled a desire minimize nurse entry into patient rooms, marked obesity, altered end‐organ function, evolving shortages, presents numerous short‐ long‐term...
Background: Limited data support high-dose oseltamivir in critically ill patients with influenza. In several recent influenza seasons, there were drug shortages. Methods: This was a retrospective cohort analysis of 57 admitted to the intensive care unit (ICU) confirmed Patients receiving compared those standard dosing. Results: When adjusted for clinically relevant predictors disease severity, including age, duration therapy, Acute Physiology and Chronic Health Evaluation II score, receipt...
Abstract Background Cefiderocol is the first antibiotic with effluent flow rate–based dosing recommendations outlined in product label for patients receiving continuous renal replacement therapy (CRRT). We aimed to investigate population pharmacokinetics of cefiderocol among CRRT and validate these recommendations. Methods A multicenter, prospective pharmacokinetic study intensive care unit was conducted (2022–2023). Blood sampling performed at steady-state concentrations were assayed by...
Vasopressors such as norepinephrine are first line for support of mean arterial pressure (MAP) in the management septic shock. Their use, however, is commonly associated with many adverse events. These detriments frequently trigger use alternative, noncatecholamine therapies, including vasopressin. Vasopressin deficiency a known physiologic consequence shock, and while guidelines recommend vasopressin addition to norepinephrine, no consensus exists on duration or ideal time cessation....