A5026596212- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Antimicrobial Resistance in Staphylococcus
- Cardiac, Anesthesia and Surgical Outcomes
- Dialysis and Renal Disease Management
- Canadian Identity and History
- Nosocomial Infections in ICU
- Blood Coagulation and Thrombosis Mechanisms
- Heart Failure Treatment and Management
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- Thermal Regulation in Medicine
- Pneumonia and Respiratory Infections
- Healthcare Decision-Making and Restraints
- Treatment of Major Depression
La Jolla Pharmaceutical (United States)
2022-2025
Innoviva (United States)
2023-2025
Gilead Sciences (United States)
2024
ON Semiconductor (United States)
2024
North Tees and Hartlepool NHS Foundation Trust
2024
Medway NHS Foundation Trust
2024
Somerset Medical Center
2018-2022
Rutgers, The State University of New Jersey
2016-2022
Centre Hospitalier Universitaire de Bordeaux
2022
Centre National de la Recherche Scientifique
2022
Abstract Background Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these might impact the response angiotensin-II treatment during vasodilatory shock. Methods In a post-hoc subgroup analysis randomized, placebo-controlled, Angiotensin Therapy for High Output Shock (ATHOS-3) trial, we compared patients with chronic angiotensin-converting use, blocker without exposure either...
Influenza and COVID-19 contribute significantly to the infectious disease burden during respiratory season, but their relative remains unknown. This study characterizes frequency severity of medically attended influenza peak 2022–2023 season in pediatric, adult, older adult populations prevalence underlying conditions among patients hospitalized with COVID-19. cross-sectional analysis included individuals Veradigm EHR Database linked Komodo claims data a medical encounter between 1 October...
Observational studies involving hemodialysis patients suggest a U-shaped relationship between BP and mortality, but the majority of these followed large, heterogeneous cohorts. To examine whether age, race, diabetes status affect association systolic (SBP; predialysis) we studied cohort 16,283 incident patients. We constructed series multivariate proportional hazards models, adding age to analyses as cubic polynomial splines model potential nonlinear relationships with mortality. Overall,...
There is a scarcity of research on immunocompromised patients with necrotizing soft-tissue infection (NSTI).To evaluate the effect status in NSTI.Single-institution retrospective cohort study at tertiary academic teaching hospital affiliated major cancer center.Patients NSTI.Treatment Brigham and Women's Hospital Dana-Farber Cancer Institute between November 25, 1995, April 2011.Necrotizing infection-associated in-hospital mortality.Two hundred one were diagnosed as having NSTI. Forty-six...
BackgroundEmpagliflozin has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory, metabolic, and haemodynamic effects. The RECOVERY trial aimed to assess safety efficacy in patients admitted hospital with COVID-19.MethodsIn randomised, controlled, open-label trial, several possible treatments are compared usual care hospitalised COVID-19. In this analysis, we eligible consenting adults who were randomly allocated 1:1 ratio either standard alone or plus oral...
Despite the high prevalence of cardiovascular disease among hemodialysis patients, relationship between age and blood pressure (BP) is not well understood. It was postulated that BP to differs patients versus general population there significant variability in dialysis unit measurements.To explore this hypothesis, patterns systolic, diastolic, mean arterial, pulse pressures using data from National Health Nutrition Examination Survey participants (n = 9242) were compared with those a cohort...
Abstract Background The physiological effects of renin-angiotensin system modulation in acute respiratory distress syndrome (ARDS) remain controversial and have not been investigated randomized trials. We sought to determine whether angiotensin-II treatment is associated with improved oxygenation shock-associated ARDS. Methods Post-hoc subgroup analysis the Angiotensin Therapy for High Output Shock (ATHOS-3) trial. studied patients who met modified Berlin ARDS criteria at enrollment. primary...
Abstract Background No standardized index exists to assess cardiovascular responsiveness angiotensin-II. We hypothesized that a of initial blood pressure response angiotensin-II treatment would be associated with clinical outcomes. Methods Using data from the Angiotensin Therapy for High Output Shock (ATHOS-3) trial, we developed an Angiotensin-II Initial MAP Response Index Treatment Effect (AIMRITE) defined as (MAP at hr1 – baseline)/study drug dose. assessed AIMRITE continuously and, based...
Objective: Analysis of data from the Burns Registry Australia and New Zealand (BRANZ) to determine extent variation between participating units in treatment specific outcomes during first 4 years its operation. Design: BRANZ, an initiative Australian Burn Association, is a clinical quality registry developed accordance with Commission on Safety Quality Healthcare national operating principles. Setting: Patients burn injury who fulfil pre-defined criteria are transferred managed designated...
Background : This study was performed to review the changing pattern of incidence severe craniomaxillofacial (CMF) trauma in Auckland over 8 years (1989–1997) and audit involvement regional plastic surgery service. Methods A prospectively collected admission data patients admitted Hospital Department Critical Care Medicine (DCCM) with CMF during 1997. comparison is made similar from 1989. Injury severity defined using Severity Score (ISS). Results Twenty‐six were DCCM Their average ISS 35....
Evidence‐based management of analgesia and sedation in COVID‐19‐associated acute respiratory distress syndrome remains limited. Non‐guideline recommended analgesic sedative medication regimens deeper targets have been employed for patients with COVID‐19 due to exaggerated requirements extended durations mechanical ventilation. This, coupled a desire minimize nurse entry into patient rooms, marked obesity, altered end‐organ function, evolving shortages, presents numerous short‐ long‐term...
We describe the discovery and preclinical characterization of a potent selective lysophosphatidic acid receptor 1 (LPAR1) antagonist with direct-acting antifibrotic mechanism.
Journal Article Assessment of low-dose i.v. ketamine infusions for adjunctive analgesia Get access Sarah Kator, Pharm.D., Pharm.D. Department Pharmacy, Mayo Clinic, Rochester, MN Address correspondence to Dr. Kator ( katosara@pharmacy.isu.edu ). Search other works by this author on: Oxford Academic Google Scholar Darin J. Correll, M.D., M.D. Brigham and Women's Hospital Harvard Medical School, Boston, MA Judy Y. Ou, M.P.H., Ph.D., Ph.D. Cancer Control Population Sciences, Huntsman Institute,...
A 71-year-old Caucasian man diagnosed with myelodysplastic syndrome developed interstitial and alveolar fibrosis after receiving a 7-day course of azacitidine therapy. The patient's pulmonary function began to deteriorate immediately the administration his chemotherapy regimen. Other potential causes toxicity were ruled out such as viral, fungal, bacterial pathogens, well other concomitant drugs. To our knowledge, this is first case report documenting biopsy-proven associated azacitidine....
Background: Historically, procalcitonin(PCT) has been used as a predictor of bacterial infection and to guide antibiotic therapy in hospitalized patients. The purpose this study was determine PCT's diagnostic utility predicting secondary pneumonia critically ill patients with severe COVID-19 pneumonia. Methods: A retrospective cohort conducted adults admitted the ICU between March 2020, 2021. All included had PCT level within 72 h presentation serum creatinine <1.5mg/dL. threshold 0.5ng/mL...
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a major cause of infection in both the hospital and community setting. Obesity is risk factor for infection, prevalence this disease reached epidemic proportions worldwide. Treatment infections special population challenge given lack data on optimal antibiotic choice dosing strategies, particularly treatment MRSA infections. associated with various physiological changes that may lead to altered pharmacokinetic...