A5081496904- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Opioid Use
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Nerve Injury and Rehabilitation
- Opioid Use Disorder Treatment
- Pediatric Pain Management Techniques
- Innovations in Medical Education
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Anesthesia and Neurotoxicity Research
- Shoulder Injury and Treatment
- Pain Mechanisms and Treatments
- Palliative Care and End-of-Life Issues
- Enhanced Recovery After Surgery
- Pharmacological Effects and Toxicity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Hernia repair and management
- Treatment of Major Depression
- Surgical Simulation and Training
- Management of metastatic bone disease
- Delphi Technique in Research
Vertex Pharmaceuticals (United States)
2023-2025
Brigham and Women's Hospital
2011-2021
Harvard University
2008-2021
Massachusetts General Hospital
2017
Barro Colorado Island
2017
Farmington Community Library
2016
Philadelphia University
2016
Center for Pain and the Brain
2006
Thomas Jefferson University
1999-2001
Thomas Jefferson University Hospital
2000
The NaV1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role transmitting signals. effect of VX-548, an oral, highly selective inhibitor NaV1.8, on control acute pain is being studied.
<ns4:p>Chronic postoperative pain is a poorly recognized potential outcome from surgery. It affects millions of patients every year, with lasting for months to years, resulting in patient suffering and ensuing economic consequences. The operations the highest incidence chronic are amputations, thoracotomies, cardiac surgery, breast Other risk factors include preoperative pain, psychological factors, demographics, intensity acute pain. Attempts prevent have often led debatable results. This...
Preoperative clinics have been shown to decrease operating room delays and cancellations. One mechanism for this positive economic impact is that medical issues are appropriately identified necessary information obtained, so knowledge of the patients' status complete before day surgery. In study, authors describe identification management in preoperative clinic.All patients coming Clinic during a 3-month period from November 1, 2003, through January 31, 2004, at Brigham Women's Hospital,...
Over the past 2 decades, many new techniques and drugs for treatment of acute pain have achieved widespread use. The main aim this study was to assess progress in their implementation using scientometric analysis. following indices were used: 1) popularity index, representing share articles on a specific technique (or drug) relative all field pain; 2) index change, degree growth publications topic compared previous period; 3) expectations, ratio number top 20 journals (>5,000) biomedical...
Background Clinical and organizational aspects of the preoperative visit can have a significant impact on patient satisfaction. The authors' previous work demonstrated that communication information from clinician to was found be most positively rated component, whereas issues, particularly waiting time, were negative. This study compares two yearly cycles satisfaction surveys assess process implementation changes. Methods authors distributed one-page questionnaire, consisting elements...
Background Age is often the sole criterion for determining need preoperative electrocardiograms. However, screening electrocardiograms have not been shown to add value above clinical information. This study was designed determine whether it possible target ordering patients most likely an abnormality that would affect management and if age alone predictive of significant abnormalities. Methods A list developed abnormalities considered enough impact management, as well a patient factors...
BackgroundPatients prescribed opioids for chronic pain may suffer from inadequate postoperative control. Ketamine is an adjuvant demonstrating analgesic and opioid-sparing effects. We hypothesize that intravenous ketamine infusion in addition to opioid-based patient-controlled analgesia (PCA) improves relief this patient population.
Background: Opioids are effective for treating acute pain but have safety, tolerability, and addiction concerns while non-opioid analgesics limited efficacy. Suzetrigine, an oral, non-opioid, small molecule, selectively inhibits the voltage-gated sodium channel 1.8 (Na V 1.8) has potential to provide efficacious safe relief pain, without concerns. Methods: To evaluate suzetrigine treatment of we conducted two phase 3, randomized, double-blind, placebo- active-controlled trials in adults with...
Many patients experience inadequate pain control due to limited options that are both efficacious and safe for treating moderate-to-severe acute pain; therefore, opioids still frequently prescribed their effectiveness despite known tolerability issues safety concerns. Suzetrigine, an oral, non-opioid, offers a promising alternative by selectively inhibiting the voltage-gated sodium channel 1.8 (NaV1.8), novel therapeutic target management. Given high selectivity of suzetrigine NaV1.8 (does...
Epidural analgesia has been shown to provide superior pain control compared with intravenous (IV) opioids after major surgical procedures. In this study, we the effect of epidural and IV morphine patient-controlled (PCA) on relief, duration hospitalization, oral nutrition, ambulation, side effects in patients undergoing a procedure (i.e., unilateral mastectomy immediate transverse rectus abdominis musculocutaneous flap reconstruction).Eighteen were prospectively randomized receive either or...
Guidelines with recommendations for monitoring type and timing of hospitalized patients opioid-induced respiratory depression have been published, yet adverse events continue to occur.This study reports on the practices 8 hospitals that volunteered pilot test a Centers Medicare & Medicaid Services e-quality measure was under development. Recommendations nurse executives are provided support patient safety.Data were collected retrospectively from electronic medical records at all receiving...
The need to measure, compare, and improve the quality of pain management is important patients, payers, health care providers. Pain after thoracic surgery can be severe, thoracoscopic approaches have not had favorable impact on as anticipated. aim this study was evaluate determinants patient satisfaction with acute effectiveness control video-assisted using a modified version Revised American Society Patient Outcome Questionnaire.We performed single-center, prospective, survey-based 300...
More than a quarter of medical costs for Medicare beneficiaries are incurred in the last year life; surgical intensity during this time is significant. This study was performed to determine types operations patients undergo their terminal year, and compare characteristics decedents with those survivors.Population 747 consecutive all-payer seen at preoperative assessment center tertiary care hospital. Patient were obtained from electronic record. Surgical indication (palliative, curative,...
Journal Article Assessment of low-dose i.v. ketamine infusions for adjunctive analgesia Get access Sarah Kator, Pharm.D., Pharm.D. Department Pharmacy, Mayo Clinic, Rochester, MN Address correspondence to Dr. Kator ( katosara@pharmacy.isu.edu ). Search other works by this author on: Oxford Academic Google Scholar Darin J. Correll, M.D., M.D. Brigham and Women's Hospital Harvard Medical School, Boston, MA Judy Y. Ou, M.P.H., Ph.D., Ph.D. Cancer Control Population Sciences, Huntsman Institute,...
BACKGROUND: The United States is in the middle of an opioid epidemic. Gastrointestinal surgery has been ranked top 3 surgical subspecialties for highest prescribing. OBJECTIVE: goal this study to determine rate and risk factors prolonged use following colectomy. DESIGN: This utilized data (2015–2017) from American College Surgeons National Surgical Quality Improvement Program 5 institutions. SETTINGS: was conducted at 2 academic community hospitals. PATIENTS: Included were 1243 patients who...
Barnet, Caryn S.; Arriaga, Alexander F.; Hepner, David L.; Correll, Darin J.; Gawande, Atul A.; Bader, Angela M. Author Information