A5003821899- COVID-19 Clinical Research Studies
- Phytochemicals and Antioxidant Activities
- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Atrial Fibrillation Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Venous Thromboembolism Diagnosis and Management
- Reconstructive Facial Surgery Techniques
- Antimicrobial Resistance in Staphylococcus
- Nonmelanoma Skin Cancer Studies
- SARS-CoV-2 and COVID-19 Research
- Gout, Hyperuricemia, Uric Acid
- Diabetes Treatment and Management
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Bacterial Identification and Susceptibility Testing
- Receptor Mechanisms and Signaling
- Drug Transport and Resistance Mechanisms
- Fungal Infections and Studies
- Antibiotic Use and Resistance
- Biochemical effects in animals
- Blood Pressure and Hypertension Studies
- Patient Safety and Medication Errors
- Sepsis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
Rutgers, The State University of New Jersey
2016-2025
Somerset Medical Center
2016-2025
University of Chieti-Pescara
2001-2024
Robert Wood Johnson University Hospital
2007-2024
Rutgers Sexual and Reproductive Health and Rights
2021
Ortho Clinical Diagnostics (United States)
2018
Hackensack University Medical Center
2017
Maine Medical Center
2017
Eckert & Ziegler (United States)
2016
Providence Park Hospital
2016
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is a pandemic causing havoc globally. Currently, there are no Food and Drug Administration (FDA)-approved drugs to treat COVID-19. In the absence of effective treatment, off-label drug use, in lieu evidence from published randomized, double-blind, placebo-controlled clinical trials, common Although it vital affected patients with antiviral drugs, knowledge gap regarding use...
Coronavirus disease 2019 (COVID-19) has become a global pandemic. Clinical characteristics regarding secondary infections in patients with COVID-19 have been reported, but detailed microbiology, risk factors, and outcomes of bloodstream (sBSIs) severe not well described.We performed multicenter case-control study including all hospitalized diagnosed blood cultures drawn from 1 March 2020 to 7 May at 3 academic medical centers New Jersey. Data collection included demographics, clinical...
The repurposing of colchicine for the treatment COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. We performed a single-center propensity score matched cohort study, including all consecutive patients admitted to community hospital between 1 March 2020 30 May 2020. Patients were stratified according receipt colchicine. primary endpoint defined as in-hospital death within 28-days follow-up. Secondary endpoints included favorable change Ordinal...
Given the obesity epidemic and prevalence of comorbidities, there is an ongoing need to understand health consequences this disease state better. Understanding gene expression signals will facilitate identification mechanisms kidney liver dysfunction/disease often present in individuals with obesity. qPCR standard method for studying changes relative expression. Reference genes (RGs) are obligatory accurately normalizing mRNA transcript levels across samples. Despite qPCR, reliability data...
Curcumin is a major component of the spice turmeric (Curcuma longa), often used in food or as dietary supplement. Many preclinical studies on curcumin suggest health benefits many diseases due to its antioxidant/anti-inflammatory and epigenetic effects. The few human curcumin's unfavorable pharmacokinetics (PK) have limited potential, leading researchers study develop formulations improve PK. purpose this clinical describe acute pharmacodynamics (PK/PD) commercially marketed normal, healthy...
Abstract The novel coronavirus disease 2019 (COVID-19) worldwide pandemic has placed a significant burden on hospitals and healthcare providers. immune response to this is thought lead an aberrant inflammatory or cytokine storm, which contributes the severity of illness. There urgent need confirm whether use tocilizumab provides benefit in individuals with COVID-19. A single-center propensity-score matched cohort study, including all consecutive COVID-19 patients, admitted medical center who...
Vitis vinifera (grape) contains various compounds with acknowledged phytochemical and pharmacological properties. Among the different parts of plant, pomace is particular interest as a winemaking industry by-product. A characterization water extract from grape Montepulciano d'Abruzzo variety (Villamagna doc) was conducted, bioactive phenolic were quantified through HPLC-DAD-MS analysis. HypoE22, hypothalamic cell line, challenged an oxidative stimulus exposed to concentrations (1 µg/mL-1...
In this study, the methanolic and infusion extracts of two species, Thymbra capitata Thymus sipyleus subsp. rosulans, were tested for their chemical composition biological abilities (antioxidant, enzyme inhibitory anti-inflammatory effects). The yielded total phenolic flavonoid contents in range 83.43-127.52 mg GAE/g 9.41-46.34 RE/g, respectively. HPLC analysis revealed rosmarinic acid to be a major component studied (15.85-26.43%). best ABTS radical scavenging ability was observed methanol...
To investigate how obesity affects the pharmacokinetics of biologics in a rat model. Male Long-Evans rats were fed high-fat diet from age 3 weeks and development was monitored by measuring body size composition (fat lean mass). The animals received nivolumab (1 8 mg/kg) or recombinant human erythropoietin (rHuEPO, 1000 IU/kg) intravenous subcutaneous injection. Serum samples collected analyzed using an enzyme-linked immunosorbent assay (ELISA). Endogenous IgG also measured study. A standard...
Abstract Background Levetiracetam (LEV) is an antiepileptic drug (AED) used to treat a variety of seizures in adult and pediatric populations. It ideal AED due its favorable pharmacokinetic (PK) pharmacodynamic profile lack interactions with other AEDs. Methods This retrospective cohort study was designed identify covariates that affect LEV clearance volume distribution generate population PK model. Adults seizure history receiving during hospital admission minimum one serum concentration...
Linn. (Amaranthaceae), commonly known as the Prickly Chaff flower, is used herbal medicine in Ivorian's culture, Africa. Nonetheless, there currently a paucity of scientific information on
Grape (Vitis vinifera L.) pomace is a residue derived from the winemaking process, which contains bioactive compounds displaying noteworthy health-promoting properties. The aim of present study was to investigate phenolic composition and protective effects water extract grape (WEGP) in colorectal cancer cell line SW480 isolated mouse colon exposed Escherichia coli lipopolysaccharide (LPS). decreased SW-480 viability, as well vascular endothelial factor A (VEGFA), hypoxia-induced 1α (HIF1α),...
Bamlanivimab and casirivimab/imdevimab are monoclonal antibody (mAb) treatments used for mild to moderate coronavirus disease 2019 (COVID-19) in high-risk patients. To date, there few data summarizing real-world evidence comparing the 2 mAbs. Additionally, insufficient guide administration timing relative symptom onset. The purpose of this study was evaluate 30-day failure rates each agent identify relationship between onset efficacy.We performed a retrospective cohort 6-month period at...