A5069760417- Fungal Biology and Applications
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactivity Studies
- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogens and Fungal Diseases
- Chemical synthesis and alkaloids
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Forest Ecology and Biodiversity Studies
- Medicinal Plants and Neuroprotection
- Phytochemical compounds biological activities
- Sesquiterpenes and Asteraceae Studies
- Plant chemical constituents analysis
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Medicinal Plants and Bioactive Compounds
- GABA and Rice Research
- Cannabis and Cannabinoid Research
- Medicinal plant effects and applications
- Microbial Natural Products and Biosynthesis
- Natural Compound Pharmacology Studies
- Phytochemistry and biological activity of medicinal plants
- Seaweed-derived Bioactive Compounds
- Herbal Medicine Research Studies
University of Perugia
2019-2025
University of Chieti-Pescara
2023-2025
Kyiv City Clinical Oncology Center
2019
The enormous burden of the COVID-19 pandemic in economic and healthcare terms has cast a shadow on serious threat antimicrobial resistance, increasing inappropriate use antibiotics shifting focus drug discovery programmes from antibacterial antifungal fields. Thus, there is pressing need for new antimicrobials involving innovative modes action (MoAs) to avoid cross-resistance rise. Thiosemicarbazones (TSCs) stand out due their easy preparation polypharmacological application, also infectious...
ABSTRACT Stellaria media L., also called chickweed, is widespread in all parts of the world. In present study, we investigated biological properties and chemical profiles different extracts (ethyl acetate, ethanol, ethanol/water, water) S. . The were examined using UHPLC/MS/MS technique. Regarding properties, antioxidant as well enzyme‐inhibiting cytotoxic effects demonstrated by vitro methods. To obtain further information about structure‐ability relationship, network pharmacology molecular...
Prostatitis is an inflammatory condition that related to multiple infectious agents, including bacteria and fungi. Traditional herbal extracts proved efficacious in controlling clinical symptoms associated with prostatitis. In this context, the aim of present study was explore efficacy from Solidago virga-aurea, Ononis spinosa, Peumus boldus, Epilobium angustifolium, Phyllanthus niruri against bacterial (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus) fungi...
The present work evaluates the aromatic waters of rosemary (Salvia rosmarinus Spenn. syn. Rosmarinus officinalis L.), sage and cypress (Cupressus sempervirens L.) obtained as innovative commercial products a hydrodistillation process. All extracts were exhaustively analysed by GC-MS, 1H-NMR, LC-MS in order to evaluate potential metabolite fingerprint differences. GC-MS appears be most exhaustive technique for qualitative identification single constituents, although this case, use 1H-NMR...
Tricholosporum goniospermum (Bres.) Guzmán ex T.J. Baroni is an excellent edible mushroom whose compounds and biological properties are still unknown. In this study, n-hexane, ethyl acetate methanol extracts from fruiting bodies liquid-cultured mycelia were compared for the analysis of phenolic compounds, evaluation scavenger (DPPH, ABTS) reducing (CUPRAC, FRAP) activities, enzyme inhibition α-amylase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE) tyrosinase. Additionally, T....
Inonotus hispidus (Bull.) P. Karst. has been used as traditional medicine for the treatment of dyspepsia, cancer, and diabetes. Numerous studies have confirmed antimicrobial, antiviral, antioxidant, anti-inflammatory, immunomodulatory, antiproliferative cytotoxic biological activities extracts from this species. The purpose study was a comparative analysis antioxidant antimicrobial methanol fruit liquid-cultured mycelia. Four compounds (N-butylbenzenesulfonamide, lauramidopropyl betaine,...
Industrial hemp is characterized by a huge amount of by-products, such as inflorescences, that may represent high-quality sources biomolecules with pharmaceutical interest. In the present study, we have evaluated phytochemical profile, including terpene and terpenophenolic compounds, essential oils (EOs) Futura 75, Carmagnola selezionata Eletta campana varieties. The EOs were also tested for antifungal properties toward Trichophyton mentagrophytes, rubrum, Arthroderma crocatum, quadrifidum,...
The aim of the present study was to investigate phenolic composition and efficacy an innovative formulation based on Mg, Vitamin B6, water extracts from Vitex agnus-castus, Crocus sativus, Melissa officinalis, Betula pendula, pubescens developed as effective tool face neuroinflammation depression symptoms occurring in premenstrual syndrome (PMS). analyzed through colorimetric liquid chromatography methods for determining content phenols flavonoids. Additionally, scavenging/reducing...
ABSTRACT Hypericum species are known for their ability to produce multiple classes of secondary metabolite and in this article the possible health‐promoting role H. empetrifolium lydium have been evaluated combining vitro silico approaches. extracts were obtained using different solvents (ethyl acetate, aceton, aceton/water, water) composition was compared NMR LC–MS based Myricetin‐3‐ O ‐glucoside, Kaemempferol ‐3‐ hyperopliphylirrin present only empetrifolium. Rutin, quercetin‐3‐...
ABSTRACT This study investigates the phytochemical composition and biopharmacological potential of three Hypericum species ( H. scabrum , lysimachioides uniglandulosum ) from Turkey. Aqueous hydroalcoholic extracts were analyzed for their total phenolic content (TPC), flavonoid (TFC), individual components (by UHPLC–HRMS technique). Antioxidant activities investigated by DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, metal chelating assays. The inhibition effects tested on acetylcholinesterase...
ABSTRACT Mushrooms have long been an integral part of human culture and health are valued for their nutritional therapeutic properties. Often referred to as a superfood, mushrooms rich in bioactive compounds that provide range benefits including antioxidant, antimicrobial, anticancer, prebiotic, antidiabetic, anti‐inflammatory effects. This review focussed on the diversity mushrooms, emphasizing medicinal significance, explores secondary metabolites with potential applications nutraceuticals...
The human gut microbiota—an intricate and dynamic ecosystem—plays a pivotal role in metabolic regulation, immune modulation, the maintenance of intestinal barrier integrity. Although antibiotic therapy is indispensable for managing bacterial infections, it profoundly disrupts microbial communities. Such dysbiosis typified by diminished diversity shifts community structure, especially among beneficial genera (e.g., Bifidobacterium Eubacterium), fosters antibiotic-resistant strains horizontal...
Oyster mushroom (Pleurotus ostreatus) has gained in the last years increasing attention due to its richness bioactive metabolites with health properties, making this variety an attractive candidate for promising developments nutraceutical and cosmeceutical fields. According conditions planned by experimental design approach, ultrasound-assisted extraction of phenol fraction from P. ostreatus was performed evaluating influence critical variables (solvent, solvent/solid ratio, time,...
Cannabis sativa products have historically been used for healing purposes; now their biological properties are supported with scientific evidence, but modern research has not yet fully developed its therapeutic potential. This study focuses on the cultivar of C. called strawberry to understand and medical potentials hydroalcoholic extracts from two different parts plant: leaves inflorescences. Two assets were investigated including antioxidant antimicrobial Additionally, quantitative...
Pleurotus spp. have been gaining popularity as a source for the creation of functional foods, nutraceuticals and novel pharmaceuticals. Despite is specious genus including 208 legitimate species, only few them such P. ostreatus are commercially accessible. The genetic metabolic diversity both at specific subspecific level therefore main concern many researchers. In addition to conventional morphological approach, molecular biochemical markers greatly contributing investigate these issues....
Mushroom polysaccharides, key components of fungal cell walls, exhibit various biological properties and hold significant medicinal industrial value. These polysaccharides are known for their like antitumor, antioxidant, anticancer, immunomodulatory, antiviral properties. particularly β-glucans, α-glucans, chitin, have been associated with health benefits. β-glucans well studied bioactivities, while α-glucans chitin gained attention prebiotic, antimicrobial, wound-healing The therapeutic...
To avail the possible pharmacological actions of Brideliaferruginea Benth., present investigation was designed to quantitatively analyze total flavonoid and phenolic contents assess various antioxidant enzyme inhibition properties leaf stem bark extracts (ethyl acetate, water methanolic) B. ferruginea. Anti-proliferative effect also investigated against human colon cancer cells (HCT116) as well antimicrobial potential multiple bacterial fungal (yeasts dermatophytes) strains. The methanolic...
Fomitopsis officinalis is a holartic polyporous mushroom that forms large fruiting bodies on old standing trees, fallen logs, or stumps. F. medicinal species most commonly used in traditional European medicine. In this study, we explore the spatial metabolic differences officinalis' parts, i.e., cap (median and apical parts) hymenium. Additionally, chromatographic analysis was conducted order to unravel composition of specialized metabolites hydroalcoholic extracts. The potential antifungal...
Mangrove forests exemplify a multifaceted ecosystem since they do not only play crucial ecological role but also possess medicinal properties. Methanolic, ethyl acetate and aqueous leaf bark extracts were prepared using homogenizer-assisted extraction (HAE), infusion maceration (with without stirring). The different screened for phytochemical profiling antioxidant capacities in terms of radical scavenging (DPPH, ABTS), reducing potential (CUPRAC, FRAP), total capacity chelating power....
Prunus mahaleb L. fruit has long been used in the production of traditional liqueurs. The also displayed scavenging and reducing activity, vitro. present study focused on unravelling peripheral central protective effects, antimicrobial but anti-COVID-19 properties exerted by water extract P. mahaleb. Anti-inflammatory effects were studied isolated mouse colons exposed to lipopolysaccharide. Neuroprotection, measured as a blunting effect hydrogen-peroxide-induced dopamine turnover, was...
The genus Pleurotus (Fr.) P. Kumm (Pleurotaceae, Basidiomycota) comprises a cosmopolitan group of mushrooms highly appreciated for their nutritional value and health-promoting benefits. Despite there being many studies about the phytochemical composition spp., are very few reports dealing with phytochemistry, antioxidant antimicrobial activities columbinus Quél. In this study, mass spectrometry ultra-performance liquid chromatography (UHPLC)-QTOF method, coupled principal component analysis...