A5014233752- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Enzyme function and inhibition
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis and Catalytic Reactions
- Sperm and Testicular Function
- Reproductive biology and impacts on aquatic species
- Synthesis and bioactivity of alkaloids
- Toxin Mechanisms and Immunotoxins
- Insect and Pesticide Research
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Medicinal plant effects and applications
- Alkaloids: synthesis and pharmacology
- Tannin, Tannase and Anticancer Activities
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activity of medicinal plants
- Neurogenetic and Muscular Disorders Research
- Reproductive Biology and Fertility
- Cholinesterase and Neurodegenerative Diseases
- Advanced Synthetic Organic Chemistry
- Fuel Cells and Related Materials
- Seaweed-derived Bioactive Compounds
Harran University
2018-2025
University of Chieti-Pescara
2024
The n-hexane, ethyl acetate, ethanol, ethanol/water (70% ethanol), and water extracts of Astragalus aduncus aerial parts were investigated for their antioxidant potential, enzyme inhibition activity (anti-acetylcholinesterase [AChE], anti-butyrylcholinesterase [BChE], antityrosinase, antiamylase, antiglucosidase) antiproliferative effect (against colon adenocarcinoma cell line [HT-29], gastric cancer [HGC-27], prostate carcinoma [DU-145], breast [MDA-MB-231], cervix [HeLa]). In addition, the...
ABSTRACT Hypericum species are known for their ability to produce multiple classes of secondary metabolite and in this article the possible health‐promoting role H. empetrifolium lydium have been evaluated combining vitro silico approaches. extracts were obtained using different solvents (ethyl acetate, aceton, aceton/water, water) composition was compared NMR LC–MS based Myricetin‐3‐ O ‐glucoside, Kaemempferol ‐3‐ hyperopliphylirrin present only empetrifolium. Rutin, quercetin‐3‐...
In the present study, we aimed to investigate chemical profiles and biological activities of different extracts (ethyl acetate, dichloromethane, ethanol, water) Pelargonium endlicherianum parts (aerial roots). Free radical scavenging, reducing power, phosphomolybdenum, metal chelating were assayed for antioxidant properties. To detect enzyme inhibitory properties, cholinesterase, amylase, glucosidase, tyrosinase chosen as target enzymes. The ethanol extract aerial contained higher amounts...
Five solvent extracts (n-hexane, ethyl acetate, ethanol, ethanol/water (70%), and water) of
ABSTRACT Bellardia trixago (L.) All. (family Orobanchaceae) is a facultative hemiparasitic plant used traditionally to cure many diseases. The present study was designed evaluate the phenolic constituents, antioxidant, enzyme inhibitory, and cytotoxic properties of aerial parts B. . Ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH extracts were prepared by maceration, while aqueous extract infusion. Rutin, 4‐hydroxy benzoic acid, ferulic p ‐coumaric hyperoside, delphinidin 3,5 diglucoside,...
Carbonic anhydrase IX (CA IX) has recently been validated as an antitumor/antimetastatic drug target. In this study, we examined the underlying molecular mechanisms and anticancer activity of sulfonamide CA inhibitors against cervical cancer cell lines. The effects several sulfonamides on HeLa, MDA-MB-231, HT-29 lines, normal lines (HEK-293, PNT-1A) viability were determined. compounds showed high cytotoxic apoptotic activities, mainly HeLa cells overexpressing IX. We also for intracellular...
Lantana camara is widely known as a garden plant, but its use for various medicinal purposes widespread in traditional medicine. In the frame of this study, L. was subjected to several different extraction techniques, including supercritical carbon dioxide extraction, accelerated solvent (ASE), homogenizer-assisted microwave-assisted ultrasound-assisted maceration, and Soxhlet extraction. The investigation encompasses analysis chemical composition alongside assessments biological activities,...
The present study investigates the chemical profile and biological activities of
Abstract Celtis australis L. (Family: Cannabaceae) is commonly used to treat many diseases like gastrointestinal problems, menstrual bleeding and amenorrhea. The present study was designed investigate the chemical constituents, antioxidant, enzyme inhibitory cytotoxic properties of different extracts from twigs, fruits leaves C. . EtOAc, EtOH, 70% EtOH aqueous were prepared by maceration. Results showed that extract had highest total phenolic content possessed remarkable antiradical, ion...
Abstract This research investigates the potential use of Jurinea mesopotamica Hand.‐Mazz. ( Asteraceae ) in cancer treatment. In this study, a plant extract was prepared using all parts J. , and its effect on proliferation normal cells tested MTT method. It found to have selective cytotoxic prostate cells, with lowest IC 50 (half‐maximal inhibitory concentration) 10μg/mL butanol (JMBE). The suppressed (67 %), disrupted organelle integrity (49 increased reactive oxidative stress (66 triggered...
Abstract This study examines efficiency of a newly synthesized sulfonamide derivative 2‐bromo‐ N ‐(4‐sulfamoylphenyl)propanamide (MMH‐1) on the inhibition Carbonic Anhydrase IX (CA IX), which is overexpressed in many solid tumors including breast cancer. The inhibitory potential MMH‐1 compound against its four major isoforms, cytosolic isoforms h CA I and II, as well tumor‐associated membrane‐bound XII, was evaluated. To this context, cytotoxic effect cancer normal cells tested found to...
In this study, the effects of supplemented inositol on sperm extenders were examined spermatozoa motility rate and duration, total antioxidant oxidant status, apoptotic DNA damage, during post-thaw process Mesopotamian Catfish (Silurus triostegus, H. 1843). The semen was frozen in diluents containing different concentrations (5, 10, 20 40 mg). Increasing levels linearly improved duration significantly (p < 0.05). MDA TOS decreased, however, TAS GSH increased increasing resulted a linear...
Background: Nature is a source of therapeutic compounds which have fewer side effects compared to synthetic drugs. Stinging nettle extract, widely-used in Anatolia, has strong antiproliferative effect on many types cancer. However, the underlying molecular mechanisms this still not known. Materials and Methods: In study, interaction Urtica dioica L. extract at different concentrations with apoptosis autophagy pathways human promyelocytic cell line (HL-60) was studied elucidate how it...
The aim of this study was to determine the levels enzymatic and nonenzymatic antioxidants DNA damage in blood rainbow trout (Oncorhynchus mykiss) exposed chlorpyrifos (CPF) protective effects curcumin (CUR) on CPFinduced oxidative stress damage.For purpose, 0.5% 1.0% CUR administered via intraperitoneal route for 45 days during exposure water containing 0.040 mg/L CPF trout.We observed a significant decrease total peroxide (TP), glutathione (GSH), GSH peroxidase (GPx), superoxide dismutase...
In this study, protective effects of Curcumin (CUR) against Chlorphyrifos (CPF)-induced oxidative stress on blood serum, liver and gill tissues rainbow trout (Oncorhynchus mykiss) were investigated.In the first group, normal water recommended diet used as control group.The second fish group was exposed to containing 0.040 mg/l CPF.The third received only 0.5% (CUR1) fourth 1% CUR (CUR2).The fifth CPF (CPF + CUR1).The sixth CPF, giving 0.1% CUR2).Samples taken from blood, total antioxidant...