A5074988328- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
- Circular RNAs in diseases
- RNA Research and Splicing
- Nuts composition and effects
- Enzyme function and inhibition
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Biological Activity of Diterpenoids and Biflavonoids
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Synthesis and Catalytic Reactions
- Nigella sativa pharmacological applications
- Sperm and Testicular Function
- Mitochondrial Function and Pathology
- Neurotransmitter Receptor Influence on Behavior
- Tea Polyphenols and Effects
- Tannin, Tannase and Anticancer Activities
- Cardiovascular Disease and Adiposity
- Essential Oils and Antimicrobial Activity
- Cholinesterase and Neurodegenerative Diseases
- ATP Synthase and ATPases Research
- Pericarditis and Cardiac Tamponade
- Molecular Biology Techniques and Applications
Harran University
2018-2025
UCLouvain
2024-2025
Gaziantep University
2014-2021
Carbonic anhydrase IX (CAIX) is a hypoxia-related protein that plays role in proliferation solid tumours. However, how CAIX increases and metastasis tumours unclear. The objective of this study was to investigate synthetic inhibitor triggers apoptosis the HeLa cell line. intracellular effects inhibition were determined with AO/EB, AnnexinV-PI, γ-H2AX staining; measurements pH (pHi), reactive oxygen species (ROS), mitochondrial membrane potential (MMP); analyses cycle, apoptotic, autophagic...
Abstract Metabolomics, unlike traditional methods for analysing the nutritional content of fruits and vegetables, enables detection low-molecular-weight metabolites (<1 kDa), including carnitine its derivatives, acylcarnitines. These compounds are integral to energy metabolism, facilitating mitochondrial transport long-chain fatty acids, cytosolic export short-chain stabilisation coenzyme A acetyl-CoA ratio, preservation membrane integrity, reduction lactate production. While profiles in...
Selective inhibition with sulphonamides of carbonic anhydrase (CA) IX reduces cell proliferation and induces apoptosis in human cancer cells. The effect on CA expression seven previously synthesised sulphonamide inhibitors, high affinity for IX, as well their the proliferation/apoptosis cancer/normal lines was investigated. Two normal three were used. Treatment resulted dose- time-dependent growth various lines. One compound showed remarkably toxicity towards IX-positive HeLa mechanisms...
The enaminone derivatives of sulfonamides (1–11) were obtained in good yield and high purity. Choline esterase (ChE) inhibitory activities the novel compounds against AChE BChE determined by Ellman’s method. Ki values for enzymes ranges 14.28˗160.17 µM, 8.30˗324.27 respectively. Compound, 9 presented activity towards with 14.28 µM 8.30 Compounds 2 10 found to be most potent showing cytotoxic effect (IC50 = 71.54 µg/mL IC50 83.59 µg/mL), respectively, on lung cancer cell line (A549) normal...
Background: In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes lung cancer. miRNAbased clinical trials are currently the preferred therapeutic strategy. Also, ceRNAs (competing endogenous RNA) would be newest and most effective approach to uncover novel interactions between mRNAs miRNAs in NSCLC carcinogenesis. There many factors influencing efficiency a miRNA suppress or silence...
Long non-coding RNAs (lncRNAs) are found to play crucial roles in several biological processes and have been associated with many complex human diseases including cancers. Several lines of evidences indicate that lncRNAs deregulated cancer tissues. In this particular study, differential expression long intergenic RNA 663 (LINC00663) was demonstrated various cell healthy tissues by using RT-PCR qPCR methods. While level LINC00663 most prominent thyroid gland uterus, it is least expressed...
The global COVID-19 pandemic, caused by the SARS-CoV-2 virus, has created great problems in healthcare systems throughout world. Although, just like other respiratory tract viral infections, it is a disease with pathophysiological processes associated general cytokine production, inflammation, cell death, and redox imbalance or oxidative stress, very little known about pathology. Also, recent studies, effect of asprosin, which an important complex role on metabolism, unknown. aim this study...
Abstract This study examines efficiency of a newly synthesized sulfonamide derivative 2‐bromo‐ N ‐(4‐sulfamoylphenyl)propanamide (MMH‐1) on the inhibition Carbonic Anhydrase IX (CA IX), which is overexpressed in many solid tumors including breast cancer. The inhibitory potential MMH‐1 compound against its four major isoforms, cytosolic isoforms h CA I and II, as well tumor‐associated membrane‐bound XII, was evaluated. To this context, cytotoxic effect cancer normal cells tested found to...
Pistachio is considered to be one of the fifty foods with highest antioxidant effect. However, anticancer effect mechanisms this plant extracts are unknown. The aim study was investigate different from green hull pistachio. cytotoxic effects solvent on cancer and normal cells were examined by cell viability assay flow cytometric analysis. levels apoptotic gene protein investigated Western Blot ELISA, qPCR. intracellular free radical exchange determined oxidative nitric oxide analyses. DNA...
Fuziline is one of the many antioxidants currently being tested to treat cardiac damage. In our study, histopathological and biochemical effects fuziline were investigated in mice with dobutamine-induced heart damage vitro.Thirty-two adult male BALB/c mice, average weight 18-20 g, randomly divided into four groups - Group 1 (sham, n=8), 2 (control, dobutamine, 3 (treatment 1, dobutamine + fuziline, 4 2, n=8). Biochemical parameters total antioxidant status (TAS), oxidant (TOS), oxidative...
Abstract This research investigates the potential use of Jurinea mesopotamica Hand.‐Mazz. ( Asteraceae ) in cancer treatment. In this study, a plant extract was prepared using all parts J. , and its effect on proliferation normal cells tested MTT method. It found to have selective cytotoxic prostate cells, with lowest IC 50 (half‐maximal inhibitory concentration) 10μg/mL butanol (JMBE). The suppressed (67 %), disrupted organelle integrity (49 increased reactive oxidative stress (66 triggered...
Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II migraine has not been considered yet. The molecular mechanisms and genetics have fully clarified yet, but it well-known that changes considerably contribute pathophysiology also complications. aim this study was to analyze plasma U-II levels along with genotype distributions allele frequencies for UTS2 Thr21Met Ser89Asn polymorphisms among patients...
Medical improvements are needed to prevent ischemia-reperfusion injury in thoracoabdominal aortic surgery. The aim of this study was determine the antioxidant effects thymoquinone, silymarin, and curcumin against associated with abdominal aorta.Twenty-five Wistar albino rats were included study. Sham, control, treatment (thymoquinone, curcumin) groups set equal numbers. Ischemia-reperfusion applied by clamping (120 minutes) de-clamping (60 infrarenal aorta all groups, except sham group....