A5028134752- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Blood disorders and treatments
- Identification and Quantification in Food
- Molecular Biology Techniques and Applications
- Acute Myeloid Leukemia Research
- interferon and immune responses
- RNA Research and Splicing
- Meat and Animal Product Quality
- Cancer-related gene regulation
- Metabolism and Genetic Disorders
- Bioactive Compounds and Antitumor Agents
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Neurogenetic and Muscular Disorders Research
- Moringa oleifera research and applications
- Herbal Medicine Research Studies
- Chromatin Remodeling and Cancer
- Cardiovascular Disease and Adiposity
- Ion Channels and Receptors
- Protein Degradation and Inhibitors
- Environmental DNA in Biodiversity Studies
Montreal Clinical Research Institute
2018-2023
McGill University
2018-2021
Gaziantep University
2014-2020
Colorectal cancer (CRC) is the most common of gastrointestinal tract. Different factors are responsible for development CRC. Transient Receptor Potential (TRP) which an important component calcium channel associated with several pathological conditions like cancer, neurodegenerative and cardiovascular diseases. Thirty members family TRP ion in mammals have been determined till now. The aim this study to investigate TRPM, TRPV TRPC gene expression levels tumor tissues CRC patients analyze...
Long non-coding RNAs (lncRNAs) are found to play crucial roles in several biological processes and have been associated with many complex human diseases including cancers. Several lines of evidences indicate that lncRNAs deregulated cancer tissues. In this particular study, differential expression long intergenic RNA 663 (LINC00663) was demonstrated various cell healthy tissues by using RT-PCR qPCR methods. While level LINC00663 most prominent thyroid gland uterus, it is least expressed...
Abstract Growth factor indepdendent 1 (GFI1) is a SNAG-domain, DNA binding transcriptional repressor which controls myeloid differentiation through molecular mechanisms and co-factors that still remain to be clearly identified. Here we show GFI1 associates with the chromodomain helicase protein 4 (CHD4) other components of Nucleosome remodeling deacetylase (NuRD) complex. In granulo-monocytic precursors, GFI1, CHD4 or GFI1/CHD4 complexes occupy sites enriched for histone marks associated...
Abstract Long noncoding RNA (lncRNA) dysregulation is known to be taking part in majority of cancers, including osteosarcoma. In one our previous studies, we showed that lncRNA MEG3 being regulated by microRNA‐664a (miR‐664a) suppresses the migratory potential osteosarcoma cells (U‐2OS). We now report a novel lncRNA, namely, ERICD, which linked transcription factor AT‐rich interaction domain 3A (ARID3A) U‐2OS cells. show ARID3A binds ERICD and indirectly interacts with each other via E2F 1...
A novel thermostable lipase from Shewanella putrefaciens was identified, expressed in Escherichia coli, characterized and used biodiesel production. Enzyme characterization carried out by enzyme assay, SDS-PAGE other biochemical reactions. The recombinant found to have a molecular mass of 29 kDa exhibited activity when Tween 80 as the substrate. purified showed maximum at pH 5.0 80°C. for transesterification canola oil waste oil. retains 50% its 90°C 30 minutes. It is also able retain 20%...
HER2 (ErbB2/Neu) is a transmembrane tyrosine kinase belonging to the ERBB family of receptors. HER2/ErbB2 also well known proto-oncogene which one most practiced molecules in cancer area. A primary function suppressing apoptosis enhance cell survival giving rise uncontrolled proliferation and tumor growth. Caspases are renowned proteases initiators as perfect finishers apoptotic process. The aim this research was study expression levels related factors CASP-3 CASP-8 several cancers including...
Breast cancer is a matter of great concern as it the most common life-threatening diseases for women.Non-coding RNAs has pivotal role in breast cancer.These non-coding RNAs, example microRNAs and long are vital regulatory molecules which play critical cancer.In this review, we discuss about interaction between lncRNA miRNAs cancer.Apart from this, exosomal involved known their use biomarkers.They can also be used agents delivering antitumor drugs.This revew compiles all data related to...
Abstract GFI1 is a DNA-binding transcription factor that regulates hematopoiesis by repressing target genes through its association with complexes containing histone demethylases such as KDM1A (LSD1) and deacetylases (HDACs). To study the consequences of disruption complex between histone-modifying enzymes, we have used knock-in mice harboring P2A mutation in coding region renders it unable to bind LSD1 associated enzymes HDACs. GFI1P2A die prematurely show increased numbers memory effector...