A5038229502- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Assisted Reproductive Technology and Twin Pregnancy
- Hepatitis B Virus Studies
- Chromosomal and Genetic Variations
- Reproductive System and Pregnancy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Sexual Differentiation and Disorders
- Chronic Kidney Disease and Diabetes
- Reproductive Biology and Fertility
- Diabetes Treatment and Management
- Reproductive Health and Technologies
- Congenital Anomalies and Fetal Surgery
- DNA Repair Mechanisms
- Birth, Development, and Health
- Gynecological conditions and treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Genetic and Kidney Cyst Diseases
- Sperm and Testicular Function
- MicroRNA in disease regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related gene regulation
- melanin and skin pigmentation
Harran University
2012-2021
Istanbul Memorial Hospital
2009-2015
Dicle University
2002-2015
Taksim German Hospital
2009
Yeditepe University Hospital
2009
Istanbul University
2003
We reviewed cytogenetic studies performed on 4216 patients who were referred to the Cytogenetics Unit at Dicle University Hospital, Diyarbair, Southeast Turkey, between 2000 and 2009.The cases grouped according reason of referral for analysis.The frequencies different types numerical structural abnormalities determined, relative frequency with abnormal karyotypes was calculated in each group.The most common requesting testing Down syndrome repeated abortions.The highest found among that due...
Abstract This study investigated parental decision‐making to terminate or continue a pregnancy after prenatal diagnosis of chromosomal abnormality among sample patients in Southeast Turkey. Between 2004 and 2007, 1068 amniocentesis tests were performed the Medical Biology Genetic Department Laboratory at Dicle University. Aneuploidy was found 38 cases (3.56%). counseling provided for couples that received abnormal results, they later interviewed asked if had continued interrupted diagnosis....
rate of chromosome heteromorphism, cases heteromorphism should not be disregarded in the etiological investigation recurrent abortions.Further research done to investigate phenotypic effects heteromorphism.
Gestational diabetes mellitus (GDM) is a glucose intolerant condition that affects 14% of all pregnancies. Diabetes (DM) occurs in 30 - 70% patients with GDM after delivery. DM and are associated structural functional deterioration the renovascular system. Our aim to investigate association Glu- 298Asp polymorphism endothelial nitric oxide synthase (eNOS) gene serum levels microalbuminuria healthy pregnancies.Serum (NO) levels, urinary excretion albumin Glu298Asp eNOS were analyzed 68 73...
Vitiligo is an acquired hypomelanotic skin disorder resulting from the loss of functional melanocytes cutaneous epidermis. Low catalase (CAT) activity and Accumulation hydrogen peroxide (H2O2) have been demonstrated in epidermis vitiligo patients. Some polymorphisms on gene may effect quantity enzyme. The aim this study was to investigate whether are associated with susceptibility Turkish population.One hundred three patients one seven gender, age ethnic matched controls were enrolled study....
X-ray repair cross-complementing group 1 (XRCC1) plays a role in repairing DNA damage during spermatogenesis. We examined the effects possible of two single nucleotide polymorphisms XRCC1 Arg194Trp and Arg399Gln gene with risk idiopathic non-obstructive azoospermia (INOA) south-east Turkey population.The genotype allele frequencies observed were by polymerase chain reaction-restriction fragment length polymorphism 102 infertile men INOA fertile controls.In our study, all are agreement...
Vitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 C>T single nucleotide polymorphism (rs2476601) has been shown be associated with various disorders.The aim this study was investigate whether the susceptibility generalized vitiligo in a Turkish population.One hundred and seven patients vitiligo, one twelve gender-, age-, ethnic-matched controls were enrolled study. Genotyping done polymerase chain...
Objective Thromogenic gene mutations has been thought to be associated with recurrent pregnancy loss in women Turkey. The aim of this study was investigate the prevalence thromogenic such as factor V Leiden (FVL, G1691T), prothrombin (G20210A), and methylene tetrahydrofolate reductase (MTHFR, C677T) mutation loss. Methods This descriptive carried out Department Obstetrics Gynaecology, Harran University School Medicine, included a total 1,507 histories between January 2010 June 2013. were...
Ring chromosomes are unusual abnormalities that observed in prenatal diagnosis. A 23-year-old patient (gravida 1, para 0) referred for amniocentesis due to abnormal maternal serum screening result the 16th week of second pregnancy. Cytogenetic analysis cultured amniyotic fluid cells revealed out ring chromosome 4. Both and paternal karyotypes were normal. Terminal deletion was both 4p 4q arms 4 by fluorescence situ hybridization (FISH). However not WHS critical region normal an additional...
Insulin resistance plays a central role in the development of gestational diabetes mellitus (GDM). The fetuin A molecule, which serum level increases during pregnancy, is an inhibitor insulin receptor tyrosine kinase and it associated with resistance. aim this study to research relationship –843A>T (rs2248690) 767C>G (rs4918) polymorphisms alpha-2-Heremans Schmid glycoprotein (AHSG) gene responsible for synthesis its association In study, 83 pregnant women GDM who applied Obstetrics...
Polymorphisms of the p53 gene, which participates in DNA repair, can affect functioning protein. The Arg and Pro variants codon 72 were shown to have different regulation properties p53-dependent repair target genes that various levels cytogenetic aberrations chronic hepatitis B patients. present study aimed examine frequency chromosomal mitotic index patients with their possible association gene exon 4 Arg72Pro (Ex4+119 G>C; rs1042522) polymorphism. Fifty-eight 30 healthy individuals...
MicroRNAs (miRNAs) are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression. Although it is reported in many studies there associations between alterations of miRNA homeostasis and pathological conditions such as cancer, psychiatric neurological diseases, cardiovascular disease autoimmune disease, the effects common genetic variants these genes on male infertility unclear. To better understand this effect, we performed a case-control study including...
Intercellular adhesion molecule-1 (ICAM-1), a member of the large immunoglobulin superfamily cell molecules, is constituent component blood–testis barrier, and it plays significant role in homeostasis spermatogenesis. The E469K polymorphism human ICAM-1 gene has been previously associated various inflammatory/autoimmune disorders. However, spermatogenesis remains unclear. aim present study to analyse possible association between male infertility with non-obstructive azoospermia (NOA)...
One of the reasons most frequent application to Clinics Pediatric Endocrinology is short stature. The major are familial stature, constitutional delay, systematic diseases, lack nutrition and endocrine disorders. Chromosomal analysis required for cases whose reason cannot be detected especially has a dysmorphic appearance. Our patient was 12 year old boy who had applied due complaint with no pathology in routine examinations whom reciprocal translocation that scoped chromosomes number 16 22...
A growing body of evidence suggest that obese individuals are under risk renal parenchymal disorders when compared to nonobese counterparts. Microalbuminuria is the early marker involvement. Although most patients carries multiple factors for microalbuminuria, some without factor may progress microalbuminuria. The present study was performed examine role ICAM-1 gene 1462A>G (K469E) polymorphism on microalbuminuria in subjects diabetes mellitus, hypertension, hiperlipidemia and older...