A5018003620- Phytochemicals and Antioxidant Activities
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Essential Oils and Antimicrobial Activity
- Clostridium difficile and Clostridium perfringens research
- Pharmacological Effects of Natural Compounds
- Garlic and Onion Studies
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Fungal Biology and Applications
- Cannabis and Cannabinoid Research
- Tea Polyphenols and Effects
- Medicinal Plant Extracts Effects
- Nicotinic Acetylcholine Receptors Study
- Medicinal Plants and Neuroprotection
- Pulmonary Hypertension Research and Treatments
- Bacteriophages and microbial interactions
- Neuroscience and Neuropharmacology Research
- Phytochemical compounds biological activities
- Piperaceae Chemical and Biological Studies
- Genomics, phytochemicals, and oxidative stress
- Bacterial Infections and Vaccines
- Breast Cancer Treatment Studies
- GABA and Rice Research
- Medicinal Plants and Bioactive Compounds
University of Chieti-Pescara
2020-2024
Toscana Life Sciences
2020-2024
University of Salerno
2022
Global Vaccines (United States)
2021
Federico II University Hospital
2015-2017
University of Siena
2012-2015
Abstract Artemisia annua L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and inflammation. In this study we aimed evaluate the effects of polarity extracts (hexane, dichloromethane, ethyl acetate, ethanol, ethanol/water (70 %) water) from A. against burden inflammation oxidative stress occurring colon tissue exposed LPS. parallel, chemical...
Industrial hemp is a multiuse crop whose phytocomplex includes terpenophenolics and flavonoids. In the present study, phenolic terpenophenolic compounds were assayed in water extract of variety Futura 75. Protective effects also investigated human fibroblast keratinocytes isolate mouse skin specimens, which exposed to hydrogen peroxide and/or (1–500 µg/mL). The results phytochemical analysis suggested cannabidiol, cannabidiolic acid rutin as prominent phytocompounds. vitro system represented...
Shigellosis accounts for substantial morbidity and mortality worldwide is the second most common cause of moderate severe diarrhoea in children.This phase 2b study (NCT03527173), conducted between August 2018 November 2019, evaluated vaccine efficacy (VE), safety, immunogenicity a Shigella sonnei GMMA candidate (1790GAHB) adults, using S. 53 G controlled human infection model. Participants (randomized 1:1) received two doses 1790GAHB or placebo (GAHB-Placebo), at day (D) 1 D29, an oral...
Vitis vinifera (grape) contains various compounds with acknowledged phytochemical and pharmacological properties. Among the different parts of plant, pomace is particular interest as a winemaking industry by-product. A characterization water extract from grape Montepulciano d'Abruzzo variety (Villamagna doc) was conducted, bioactive phenolic were quantified through HPLC-DAD-MS analysis. HypoE22, hypothalamic cell line, challenged an oxidative stimulus exposed to concentrations (1 µg/mL-1...
Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. italica is a medicinal plant traditionally used for its analgesic effects, in present study, phytochemical composition biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, water extracts aerial parts were investigated determining phenolic composition,...
Pelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, chemical composition and bio-pharmacological properties of P. extracts were investigated. Enzyme inhibition scavenging/reducing water, methanol, ethyl acetate assayed. The also studied in an ex vivo experimental model colon inflammation, this context gene expression cyclooxygenase-2 (COX-2) tumor necrosis factor α (TNFα) Additionally, cancer HCT116 cells, transient receptor...
Abstract Inflammatory bowel disease (IBD) is a morbid condition characterized by relapsing–remitting inflammation of the colon, accompanied persistent gut dysmotility and abdominal pain. Different reports demonstrated biological activities aged black garlic (ABG), including anti‐inflammatory antioxidant effects. We aimed to investigate beneficial effects exerted ABGE on colon using ex vivo in experimental models. investigated an ABG water extract (ABGE) rat specimens exposed E. coli...
Industrial hemp is characterized by a huge amount of by-products, such as inflorescences, that may represent high-quality sources biomolecules with pharmaceutical interest. In the present study, we have evaluated phytochemical profile, including terpene and terpenophenolic compounds, essential oils (EOs) Futura 75, Carmagnola selezionata Eletta campana varieties. The EOs were also tested for antifungal properties toward Trichophyton mentagrophytes, rubrum, Arthroderma crocatum, quadrifidum,...
In this study, the methanolic and infusion extracts of two species, Thymbra capitata Thymus sipyleus subsp. rosulans, were tested for their chemical composition biological abilities (antioxidant, enzyme inhibitory anti-inflammatory effects). The yielded total phenolic flavonoid contents in range 83.43-127.52 mg GAE/g 9.41-46.34 RE/g, respectively. HPLC analysis revealed rosmarinic acid to be a major component studied (15.85-26.43%). best ABTS radical scavenging ability was observed methanol...
Inflammatory bowel diseases (IBDs) are chronic and multifactorial inflammatory conditions of the colonic mucosa (ulcerative colitis), characterized by increased unbalanced immune response to external stimuli. Garlic its bioactive constituents were reported exert various biological effects, including anti-inflammatory, antioxidant immunomodulatory activities. We aimed evaluate protective effects a hydroalcoholic (GHE) water (GWE) extract from Sicilian variety garlic, known as Nubia red on an...
The aim of the present study was to investigate phenolic composition and efficacy an innovative formulation based on Mg, Vitamin B6, water extracts from Vitex agnus-castus, Crocus sativus, Melissa officinalis, Betula pendula, pubescens developed as effective tool face neuroinflammation depression symptoms occurring in premenstrual syndrome (PMS). analyzed through colorimetric liquid chromatography methods for determining content phenols flavonoids. Additionally, scavenging/reducing...
Medicinal plants and natural compounds have been considered alternative therapeutic options for counteracting postmenopausal disorders thanks to their different concomitant effects, including antioxidant anti-inflammatory properties the regulation of hormone activity. It is important highlight that efficacy medicinal increases when used in combination, thus making development herbal formulations rational. Therefore, present study aimed evaluate phytochemical pharmacological an innovative...
Contrast-enhanced mammography (CEM) is rapidly expanding as a credible alternative to MRI in various clinical settings.
Shigellosis is a leading cause of diarrheal disease in low-middle-income countries (LMICs). Effective vaccines will help to reduce the burden, exacerbated by increasing antibiotic resistance, most susceptible population represented young children. A challenge for broadly protective vaccine against shigellosis cover epidemiologically relevant serotypes among >50 Shigella circulating worldwide. The GMMA platform has been proposed as an innovative delivery system O-antigens, and we have...
Grape (Vitis vinifera L.) pomace is a residue derived from the winemaking process, which contains bioactive compounds displaying noteworthy health-promoting properties. The aim of present study was to investigate phenolic composition and protective effects water extract grape (WEGP) in colorectal cancer cell line SW480 isolated mouse colon exposed Escherichia coli lipopolysaccharide (LPS). decreased SW-480 viability, as well vascular endothelial factor A (VEGFA), hypoxia-induced 1α (HIF1α),...
Shigella is associated with a significant burden of disease worldwide among individuals all ages and the major cause moderate severe diarrhea in children under five years age low- middle-income countries. Several candidate vaccines against species are currently clinical development. The investigational 1790GAHB vaccine sonnei based on GMMA (Generalized Modules for Membrane Antigens) technology. was well tolerated induced high antibody levels early-phase trials both -endemic non-endemic...
Cannabis sativa products have historically been used for healing purposes; now their biological properties are supported with scientific evidence, but modern research has not yet fully developed its therapeutic potential. This study focuses on the cultivar of C. called strawberry to understand and medical potentials hydroalcoholic extracts from two different parts plant: leaves inflorescences. Two assets were investigated including antioxidant antimicrobial Additionally, quantitative...
Multiple studies demonstrated biological activities of aged black garlic, including anti-inflammatory, antioxidant, and cardioprotective effects. We aimed to investigate the protective effects an garlic water extract (ABGE) alone or in association with multivitamins consisting combined Vitamins D, C, B12, on mouse heart specimens exposed E. coli lipopolysaccharide (LPS). Moreover, we studied hydrogen sulphide (H2S) releasing properties membrane hyperpolarization effect Formulation composed...
We report data from Stage 1 of an ongoing two-staged, phase I/II randomized clinical trial (NCT05073003) with a 4-component Generalized Modules for Membrane Antigens-based vaccine against Shigella sonnei and S. flexneri 1b, 2a 3a (altSonflex1-2-3, GSK).
Oxidative stress (OS) is important in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA) and its experimental model – adjuvant (AA). Antioxidants are scarcely studied autoimmunity, future analyses needed to assess effects ameliorating these diseases. Although there studies about antioxidants on course RA, their role combination therapy has not yet been detail, especially extra-articular manifestations AA. During 28-d administration pinosylvin (PIN) monotherapy with...