A5029455714- Genetics and Neurodevelopmental Disorders
- Skin Protection and Aging
- Air Quality and Health Impacts
- Medical and Biological Ozone Research
- Climate Change and Health Impacts
- Advancements in Transdermal Drug Delivery
- Antioxidant Activity and Oxidative Stress
- Family and Disability Support Research
- Bee Products Chemical Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Autism Spectrum Disorder Research
- Hydrogen's biological and therapeutic effects
- Adenosine and Purinergic Signaling
- Inflammasome and immune disorders
- Phytochemicals and Antioxidant Activities
- RNA modifications and cancer
- Vitamin C and Antioxidants Research
- Genomics, phytochemicals, and oxidative stress
- Wound Healing and Treatments
- Child Nutrition and Feeding Issues
- Endoplasmic Reticulum Stress and Disease
- Nutritional Studies and Diet
- Autophagy in Disease and Therapy
- Paraoxonase enzyme and polymorphisms
- Alzheimer's disease research and treatments
University of Ferrara
2016-2025
Kyung Hee University
2015-2025
North Carolina State University
2016-2025
North Central State College
2016-2025
David H. Murdock Research Institute
2016-2024
University of Siena
2000-2023
National Institute of Environmental Health Sciences
2018-2023
Animal Health Institute
2021
University of Canberra
2017
University of Padua
2014
Since the ability of cancer cells to evade apoptosis often limits efficacy radiotherapy and chemotherapy, autophagy is emerging as an alternative target promote cell death. Therefore, we wondered whether Rottlerin, a natural polyphenolic compound with antiproliferative effects in several types, can induce death MCF-7 breast cells. The line good model chemo/radio resistance, being both resistant, due deletion caspase 3 gene, high expression antiapoptotic protein Bcl-2, low autophagic Beclin-1...
Epidemiological studies suggest a correlation between increased airborne particulate matter (PM) and adverse health effects. The mechanisms of PM-health effects are believed to involve oxidative stress inflammation. To evaluate the ability PM promoting skin tissue damage, one main organs exposed outdoor pollutants, we analyzed effect concentrated ambient particles (CAPs) in reconstructed human epidermis (RHE) model. RHE tissues were 25 or 100 µg/ml CAPs for 24 48 h. Data showed that seems be...
ABSTRACT Ozone is well recognized as a bactericidal agent and its beneficial effect on wound healing could be consequence of this property. Because ozone itself does not penetrate the cells but immediately reacts with polyunsaturated fatty acids, effects should results oxidative reaction. For reason, ozonated oils way to deliver messengers skin. This paper evaluated therapeutic three different grades sesame oil in acute cutaneous wounds made skin SKH1 mice. Specifically, closure rate,...
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of cases by loss-of-function mutations gene encoding methyl-CpG binding protein 2 (MECP2). High circulating levels oxidative stress (OS) markers patients suggest involvement OS RTT pathogenesis. To investigate occurrence brain damage Mecp2 mutant mouse models, several were evaluated whole brains Mecp2-null (pre-symptomatic, symptomatic, and rescued) Mecp2-308...
Mangiferin is a natural glucosyl xanthone with antioxidant and anti-inflammatory activity, making it suitable for protection against cutaneous diseases. In this study ethosomes transethosomes were designed as topical delivery systems mangiferin. A preformulation was conducted using different surfactants in association phosphatidylcholine. Vesicle dimensional distribution monitored by photon correlation spectroscopy, while capacity cytotoxicity respectively assessed free radical scavenging...
The present study is aimed to design ethosomes and transethosomes for topical administration of quercetin. To overcome quercetin low bioavailability, scarce solubility poor permeability that hamper its pharmaceutical use, the drug was loaded in based on different concentrations phosphatidylcholine. Vesicle morphology studied by cryogenic transmission electron microscopy, while size distribution entrapment capacity were evaluated up 3 months, respectively, photon correlation spectroscopy...
Diesel particulate matter is one of the most dangerous environmental stressors affecting human health. Many plant-derived compounds with antioxidant and anti-inflammatory properties have been proposed to protect skin from pollution damage. Curcumin (CUR) has a plethora pharmacological activities, including anticancer, antimicrobial, antioxidant. However, it low bioavailability due its difficult absorption rapid metabolism elimination. CUR encapsulation in nanotechnological systems...
Flavonoids are potent antioxidants and have been associated with lowering the risk of cardiovascular diseases. In this study, effect flavonoids (monomers, dimers a trimer) as well French maritime pine bark extract, Pycnogenol, on NO production, tumor necrosis factor‐α (TNF‐α) secretion nuclear factor (NF)‐κB activity was compared. Monomers repressed TNF‐α NF‐κB‐dependent gene expression induced by interferon γ, whereas trimeric procyanidin C2 Pycnogenol enhanced these parameters. addition,...