Stefano Manfredini

ORCID: 0000-0003-1348-4422
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Research Areas
  • Essential Oils and Antimicrobial Activity
  • Synthesis and biological activity
  • Synthesis and Characterization of Heterocyclic Compounds
  • Synthesis and Biological Evaluation
  • Synthesis and Reactions of Organic Compounds
  • Biochemical and Molecular Research
  • Skin Protection and Aging
  • HIV/AIDS drug development and treatment
  • Phytochemistry and Biological Activities
  • Synthesis and Reactivity of Heterocycles
  • Synthesis of heterocyclic compounds
  • Phytochemicals and Antioxidant Activities
  • Antioxidant Activity and Oxidative Stress
  • Click Chemistry and Applications
  • Free Radicals and Antioxidants
  • Synthesis of Organic Compounds
  • Carbohydrate Chemistry and Synthesis
  • Chemical Synthesis and Analysis
  • Synthesis and Catalytic Reactions
  • Asymmetric Synthesis and Catalysis
  • Advancements in Transdermal Drug Delivery
  • Retinoids in leukemia and cellular processes
  • Fluorine in Organic Chemistry
  • Bee Products Chemical Analysis
  • Synthesis and pharmacology of benzodiazepine derivatives

University of Ferrara
2016-2025

Cardiff University
2023

Arcispedale Sant'Anna
2016-2020

University of Trieste
2004

University of Cagliari
2004

University of Parma
2004

University of Portsmouth
1999

Rega Institute for Medical Research
1997-1999

KU Leuven
1997-1999

Umeå University
1999

It has been suggested that oxidative stress may play a role in the pathogenesis of Autism Spectrum Disorders (ASD), but literature reports somewhat contradictory results. To further investigate issue, we evaluated high number peripheral parameters, and some related issues such as erythrocyte membrane functional features lipid composition. Twenty-one autistic children (Au) aged 5 to 12 years, were gender age-matched with 20 typically developing (TD). Erythrocyte thiobarbituric acid reactive...

10.1371/journal.pone.0066418 article EN cc-by PLoS ONE 2013-06-19

We here report the results of our investigations carried out on verbascoside, a phenylpropanoid glycoside known for its antioxidant, anti-inflammatory and photoprotective actions. Verbascoside was obtained from Buddleia davidii meristematic cells, in turn using sustainable biotechnology platform which employs an vitro plant cell culture technology. first investigated to assess behaviour active ingredient solution or finished preparations, view potential topical use, especially skin...

10.3390/molecules16087068 article EN cc-by Molecules 2011-08-18

Moringa oleifera has gained increasing popularity as a food supplement but not in the pharmaceutical and cosmetic area. The aim of this study was preparation, characterization, evaluation extracts from leaves herbal sun care phytocomplex. Three different leaves, Senegal, have been prepared chemically characterized phenolic fraction by HPLC-DAD Folin–Ciocalteu test. To explore photoprotective properties, an extensive UV filtering, antioxidant (DPPH, FRAP, ORAC, PCL), anti-hyperproliferative...

10.3390/molecules23030664 article EN cc-by Molecules 2018-03-15

Diesel particulate matter is one of the most dangerous environmental stressors affecting human health. Many plant-derived compounds with antioxidant and anti-inflammatory properties have been proposed to protect skin from pollution damage. Curcumin (CUR) has a plethora pharmacological activities, including anticancer, antimicrobial, antioxidant. However, it low bioavailability due its difficult absorption rapid metabolism elimination. CUR encapsulation in nanotechnological systems...

10.3390/antiox13010091 article EN cc-by Antioxidants 2024-01-11

Aims: The goal of this work was to investigate the influence DMSO, garlic extract and p‐coumaric acid on bacterial quorum sensing (QS). Methods Results: decreases in QS responses reporter strains Escherichia coli pSB401 pSB536, Agrobacterium tumefaciens NTL4, Chromobacterium violaceum 5999 wt 494, Pseudomonas putida IsoF/gfp environmental chlororaphis were quantified relation growth inhibitory effects. DMSO showed no significant QS‐specific effects tested even at close‐to‐lethal...

10.1111/j.1472-765x.2009.02704.x article EN Letters in Applied Microbiology 2009-07-25

Dry eye syndrome is a common disease which can damage the corneal epithelium. It treated with drops to stimulate tear production and hydrate surface. The most prescribed artificial remedies contain hyaluronic acid (HA), enhances epithelial wound healing, improving tissue health. To best of our knowledge, only few recent studies have investigated cross-linked HA (HA-CL) in for human applications. This work consists an vitro evaluation re-epithelialization ability two different preparations...

10.3390/molecules22122104 article EN cc-by Molecules 2017-11-30

A polar head and an apolar tail chemically characterize surfactants, they show different properties are categorized by factors such as charge molecular weight. They work reducing the surface tension between oil water phases to facilitate formation of one homogeneous mixture. In this respect, represent unavoidable ingredients, their main application is in production detergents, if not most important categories cosmetics. Their role very important, it should be remembered that was precisely...

10.3390/cosmetics7020046 article EN cc-by Cosmetics 2020-06-11

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosidesStefano Manfredini, Rita Bazzanini, Pier Giovanni Baraldi, Mario Guarneri, Daniele Simoni, Maria E. Marongiu, Alessandra Pani, Paolo La Colla, Enzo TramontanoCite this: J. Med. Chem. 1992, 35, 5, 917–924Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published...

10.1021/jm00083a017 article EN Journal of Medicinal Chemistry 1992-03-01

Wild Amazonian basil Ocimum micranthum Willd. (O. campechianum Mill.) Labiatae essential oil was analyzed by GC and GC-MS: 31 compounds were identified. The main components eugenol (46.55 ± 5.11%), β-caryophyllene (11.94 1.31%), β-elemene (9.06 0.99%), while a small amount of linalool (1.49 0.16%) detected. tested for its in vitro food-related biological activities compared with common basilicum Thymus vulgaris commercial oils. Radical scavenging activity evaluated employing...

10.1021/jf035145e article EN Journal of Agricultural and Food Chemistry 2004-05-05

An efficient method for preparing ß-hydroxy ketones from 2-isoxazolines by N-O bond cleavage promoted molybdenum hexacarbonyl is described.

10.1055/s-1987-27915 article EN Synthesis 1987-01-01

The phenolic compound phloridzin (phloretin 2′-O-glucoside, variously named phlorizin, phlorrhizin, phlorhizin or phlorizoside) is a prominent member of the chemical class dihydrochalcones, which are phenylpropanoids. Phloridzin specifically found in apple and juice known for its biological properties. In particular we were attracted by potential dermo-cosmetic applications. Here report synthesis, stability studies antimicrobial activity F2, new semi-synthetic derivative phloridzin....

10.3390/molecules171113275 article EN cc-by Molecules 2012-11-07
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