A5078275872- HIV/AIDS drug development and treatment
- Prion Diseases and Protein Misfolding
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical and Molecular Research
- Synthesis and biological activity
- Cholesterol and Lipid Metabolism
- HIV Research and Treatment
- Synthesis and Biological Evaluation
- Metal complexes synthesis and properties
- Alzheimer's disease research and treatments
- Synthesis and Reactions of Organic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Alcoholism and Thiamine Deficiency
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Neurological diseases and metabolism
- Ferroelectric and Piezoelectric Materials
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Immunology Research
- Mitochondrial Function and Pathology
- Synthesis of heterocyclic compounds
- Lanthanide and Transition Metal Complexes
Instituto Politécnico Nacional
2025
Maharaja Sriram Chandra Bhanja Deo University
2023-2024
International Fund for Agricultural Development
2022
University of Cagliari
2009-2019
Policlinico Universitario di Catania
2018
Società Italiana di Nefrologia
2018
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2000-2017
Bushehr University of Medical Sciences
2009
Istituto Pasteur
2002
University of Palermo
1999
Neurodegeneration, a common feature for many brain disorders, has severe consequences on the mental and physical health of an individual. Typically human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people, progress slowly, lead to disability premature death; however they may occur at all ages. Despite extensive research investments, current therapeutic interventions against these disorders treat solely symptoms. Therefore, since underlying...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosidesStefano Manfredini, Rita Bazzanini, Pier Giovanni Baraldi, Mario Guarneri, Daniele Simoni, Maria E. Marongiu, Alessandra Pani, Paolo La Colla, Enzo TramontanoCite this: J. Med. Chem. 1992, 35, 5, 917–924Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published...
Alterations in plasma lipid profile and intracellular cholesterol homoeostasis have been described various malignancies; however, significance of these alterations, if any, cancer biology is not clear. The aim the present study was to investigate a possible correlation between alterations metabolism expansion leukaemia cell numbers.Lipid profiles primary cells isolated from patients with acute or chronic lymphocytic (ALL CLL) were studied.Decreased levels HDL-C observed leukaemic patients,...
Abstract Food insecurity in the African context is a critical issue; yet total food losses are estimated at 15.9% and 17.2% quantity caloric value, respectively (FAO, 2019). Currently across continent, there insufficient funding lack of policy mechanisms to support interdisciplinary analytical approaches data collection systems better inform reduction loss. This paper highlights need for paradigm shift current research development programs aimed loss reduction, as demonstrated by findings...
Intracellular cholesterol metabolism was reported to modulate amyloid-β (Aβ) generation in Alzheimer's disease (AD). Results presented herein demonstrated that, like brain cells, cultured skin fibroblasts from AD patients contained more e
Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated the host. PrP(Sc) propagation involves conversion from its normal isoform, PrP(C), by a seeded or templated polymerization mechanism. Such mechanism also basis RT-QuIC eQuIC assays which use recombinant PrP (rPrP(Sen)) as substrate. These ultrasensitive detection have been developed for TSE prions...
Alzheimer's disease is the most common progressive neurodegenerative disease. In recent years, numerous progresses in discovery of novel molecular biomarkers brain as well biological fluids have been made. Among them, those involving lipid metabolism are emerging potential candidates. particular, an accumulation neutral lipids was recently found by us skin fibroblasts from patients. Therefore, with aim to assess whether peripheral alterations cholesterol homeostasis might be relevant...
A novel series of 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazole (DAMNI) analogues were synthesized and tested in cell-based assays enzyme against HIV-1 recombinant reverse transcriptase (RT). Preparation the new derivatives was performed by reacting appropriate benzhydrols or correspondig bromides with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole 3-hydroxypropyl homologue. Several compounds showed anti-HIV-1 activity submicromolar range. Structure−activity relationship studies...
The iminoquinone is an important moiety of a large number antineoplastic drugs and plays significant role in the nucleus actinomycins, powerful, highly toxic, natural antibiotics that target DNA as intercalating agents. A series polycyclic iminoquinonic compounds, 2-amino-3H-phenoxazin-3-one (1), 2-amino-1,9-diacetyl-3H-phenoxazin-3-one (2), 2-acetylamino-3H-phenoxazin-3-one (3), 3H-phenoxazin-3-one (4), 5H-pyrido[3,2-a]phenoxazin-5-one (5), 5H-pyrido[3,2-a]phenothiazin-5-one (6), strictly...
In this paper we describe our structure-based ligand design, synthetic strategy, and structure−activity relationship (SAR) studies that led to the identification of thiocarbamates (TCs), a novel class non-nucleoside reverse transcriptase inhibitors (NNRTIs), isosteres phenethylthiazolylthiourea (PETT) derivatives. Assuming as lead compound O-[2-(phthalimido)ethyl]phenylthiocarbamate 12, one precursors previously described acylthiocarbamates (Ranise, A.; et al. J. Med. Chem. 2003, 46,...
The current model of poliovirus morphogenesis postulates a fundamental role for procapsid, 80S shells that, upon interaction with viral RNA and subsequent proteolytic cleavage, give rise to complete virus particles. Although sedimenting particles can, indeed, be isolated from cytoplasmic extracts infected cells, their physical properties differ those reported procapsids. Far being stable structures, they can dissociated by pH 8.5 0.1% sodium dodecyl sulfate into slower-sedimenting subunits....
Cholesterol homeostasis dysfunction has been reported to have role in the pathogenesis of Alzheimer disease (AD). Therefore, changes cholesterol metabolism blood components may help develop new potential AD biomarkers. In this study metabolism-related gene expression genes were evaluated peripheral mononuclear cells (PBMCs) from subjects, their first degree relatives (FDR) and two groups age matched controls (C1 > 80 years, C2 < 60 years). The three related APP processing was also...
Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine 5 were synthesized by diazotization substituted 2-(2-aminophenyl)indoles followed an intramolecular coupling reaction diazonium group with indole nitrogen. To obtain indolobenzotriazine it was necessary to protect 3 position nucleus avoid cyclization into indolo[3,2-c]cinnoline 4. Indolobenzotriazines 5a−g evaluated in vitro for antitumor activity against a panel leukemia-, lymphoma-, carcinoma-, and neuroblastoma-derived...
A novel series of potent, selective HIV-1 N-acylthiocarbamate (ATC) nonnucleoside reverse transcriptase inhibitors (NNRTIs) is described. The title compounds were synthesized through a highly convergent, one-pot procedure. In cell-based assays, the lead compound (17c) prevented multiplication with an EC50 8 μM. optimization strategy was developed by single or multiple modifications three molecular portions, in which 17c notionally divided. Molecular modeling studies led to synthesis...