A5013246528- Garlic and Onion Studies
- Extracellular vesicles in disease
- Dermatology and Skin Diseases
- Genetics and Neurodevelopmental Disorders
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Phytochemistry and biological activities of Ficus species
- Pineapple and bromelain studies
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Growth Hormone and Insulin-like Growth Factors
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Natural Compounds
- Quantum Dots Synthesis And Properties
University of Chieti-Pescara
2023-2025
Abstract Inflammatory bowel disease (IBD) is a morbid condition characterized by relapsing–remitting inflammation of the colon, accompanied persistent gut dysmotility and abdominal pain. Different reports demonstrated biological activities aged black garlic (ABG), including anti‐inflammatory antioxidant effects. We aimed to investigate beneficial effects exerted ABGE on colon using ex vivo in experimental models. investigated an ABG water extract (ABGE) rat specimens exposed E. coli...
Chimeric Antigen Receptor (CAR) T cell-derived Extracellular Vesicles (EVs) might represent a new therapeutic tool for boosting CAR-T cell antileukemic effects. Here, cohort of 22 patients infused with CD19.CAR-T cells was monitored the presence circulating CD19.CAR+-T EVs (CD19.CAR+EVs), which were then separated and functionally characterized their killing abilities. A GMP-compliant separation method also developed. Results demonstrated that CD19.CAR+EVs detectable in peripheral blood up...
Multiple studies demonstrated biological activities of aged black garlic, including anti-inflammatory, antioxidant, and cardioprotective effects. We aimed to investigate the protective effects an garlic water extract (ABGE) alone or in association with multivitamins consisting combined Vitamins D, C, B12, on mouse heart specimens exposed E. coli lipopolysaccharide (LPS). Moreover, we studied hydrogen sulphide (H2S) releasing properties membrane hyperpolarization effect Formulation composed...
Growth hormone (GH)-releasing (GHRH) has been suggested to play a crucial role in brain function. We aimed further investigate the effects of novel GHRH antagonist Miami (MIA) series, MIA-602, on emotional disorders and explore relationships between endocrine system mood disorders. In this context, induced by MIA-602 were also analyzed comparison vehicle-treated mice with GH deficiency due generalized ablation gene (GHRH knock out (GHRHKO)). show that chronic subcutaneous administration wild...
Pancreatic cancer (PC) has a poor prognosis and displays resistance to immunotherapy. A better understanding of tumor-derived extracellular vesicles (EVs) effects on immune responses might contribute improved EVs derived from Capan-2 BxPC-3 PC cells isolated by ultracentrifugation were characterized atomic force microscopy, western blot (WB), nanoparticle tracking analysis label-free proteomics. Fresh PBMCs healthy donors treated with PC- or control-derived heterologous followed flow...
Pancreatic cancer (PC) has a poor prognosis and displays resistance to immunotherapy. A better understanding of tumor-derived extracellular vesicle (EV) effects on immune responses might contribute improved EVs derived from Capan-2 BxPC-3 PC cells isolated by ultracentrifugation were characterized atomic force microscopy, Western blot (WB), nanoparticle tracking analysis, label-free proteomics. Fresh PBMCs healthy donors treated with PC- or control-derived heterologous EVs, followed flow...
Background/Objectives: Urinary tract infections (UTIs) are that involve the urethra, bladder, and, in much more severe cases, even kidneys. These represent one of most common diseases worldwide. Various pathogens responsible for this condition, being Escherichia coli (E. coli). Bromelain is a proteolytic complex obtained from stem and stalk Ananas comosus (L.) Merr. showing several beneficial activities. In addition to bromelain, N-acetylcysteine (NAC) has also been used. Methods: The...