A5010992446- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Adenosine and Purinergic Signaling
- Pregnancy and preeclampsia studies
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Venous Thromboembolism Diagnosis and Management
- Cell Adhesion Molecules Research
- Alzheimer's disease research and treatments
- Reproductive Biology and Fertility
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Allergic Rhinitis and Sensitization
University of Chieti-Pescara
2016-2025
Centre for Excellence in Mining Innovation
2015
University Foundation
2014
Brighton and Sussex Medical School
2009
Regulatory T Cells (Tregs) are a T-lymphocyte subset involved in the maintenance of immune peripheral tolerance. Despite evidence adaptive system's role Alzheimer's Disease (AD), involvement Tregs is still not clear. We focused on Flow-Cytometry analysis Treg frequencies and phenotypes AD. The aim study to analyse similarities differences profile between Multiple Sclerosis. (CD4+/CD25high/CD127low-neg) were identified using an innovative Flow Cytometry method subtyped as Resting (analysed...
Multiple Sclerosis (MuS) is a complex multifactorial neuropathology, resulting in heterogeneous clinical presentation. A very active MuS research field concerns the discovery of biomarkers helpful to make an early and definite diagnosis. The sphingomyelin pathway has emerged as molecular mechanism involved MuS, since high levels ceramides cerebrospinal fluid (CSF) were related axonal damage neuronal dysfunction. Ceramides are hydrolysis products sphingomyelins through reaction catalyzed by...
Molecular markers for prostate cancer (PCa) are required to improve the early definition of patient outcomes. Atypically large extracellular vesicles (EVs), referred as "Large Oncosomes" (LO), have been identified in highly migratory and invasive PCa cells. We recently developed characterized DU145R80 subline, selected from parental DU145 cells resistant inhibitors mevalonate pathway. showed different proteomic profile compared cells, along with altered cytoskeleton dynamics a more...
Primary open-angle glaucoma (POAG) represents the leading cause of irreversible blindness worldwide and is a multifactorial, chronic neurodegenerative disease characterized by retinal ganglion cell visual field loss. There are many factors that associated with risk developing POAG, increased intraocular pressure being one most prevalent. Due to asymptomatic nature disease, diagnosis POAG often occurs too late, which necessitates development new effective screening strategies for early...
Extracellular vesicles (EVs) are released by shedding during different physiological processes and increasingly thought to be new potential biomarkers. However, the impact of pre-analytical processing phases on final measurement is not predictable for this reason, translation basic research into clinical practice has been precluded. Here we have optimized a simple procedure in combination with polychromatic flow cytometry (PFC), identify, classify, enumerate, separate circulating EVs from...
Rationale. Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified. Objectives. We aimed to verify whether microparticles (MPs) released from thrombin-activated platelets differed in obese nonobese women number, size, proteomics cargo capacity modulate vitro expression of (i) genes related epithelial mesenchymal transition (EMT) endothelial (EndMT), (ii) cyclooxygenase(COX)-2 involved production angiogenic inflammatory...
Helicobacter pylori, a Gram-negative neutrophilic pathogen, is the cause of chronic gastritis, peptic ulcers, and gastric cancer in humans. Current therapeutic regimens suffer from an emerging bacterial resistance rate poor patience compliance. To improve discovery compounds targeting alternative enzymes or essential pathways such as carbonic anhydrases (CAs), we assessed anti-H. pylori activity thymol carvacrol terms CA inhibition, isoform selectivity, growth impairment, biofilm production,...
The level of environmental microplastics in the sea is constantly increasing. They can enter human body with food, be absorbed through gut and have negative effects on organism's health after its digestion. To date, (MPs) are considered new pollutants air they attracting wide attention. possible toxic MPs isolated at different depths 1, 24 78 m were explored an vitro model gingival fibroblasts (hGFs). from showed size then divided into sample groups: m. results obtained revealed that able to...
Glioblastoma multiforme (GBM) is a lethal disease characterized by an overall survival of about 1 year, making it one the most aggressive tumours, with very limited therapeutic possibilities. Specific biomarkers for early diagnosis as well innovative strategies are urgently needed to improve management this deadly disease. In work, we demonstrated that vesicular galectin-3-binding protein (LGALS3BP), glycosylated overexpressed in variety human malignancies, potential GBM marker and can be...
Platelet-cancer cell interactions modulate tumor metastasis and thrombosis in cancer. Platelet-derived extracellular vesicles (EVs) can contribute to these outcomes.We characterized the medium-sized EVs (mEVs) released by thrombin-stimulated platelets of colorectal cancer (CRC) patients healthy subjects (HS) on capacity induce epithelial-mesenchymal transition (EMT)-related genes cyclooxygenase (COX)-2(PTGS2), thromboxane (TX)B2 production cocultures with four lines. mEVs were assessed for...
Abstract Treatment response assessment of rectal cancer patients is a critical component personalized care and it allows to identify suitable candidates for organ-preserving strategies. This pilot study employed novel multi-omics approach combining MRI-based radiomic features untargeted metabolomics infer treatment at staging. The metabolic signature highlighted how tumor cell viability predictively down-regulated, while the oxidative stress was up-regulated in responder patients, showing...
Circulating endothelial cells (CEC) and their progenitors (EPC) are restricted subpopulations of peripheral blood (PB), cord (CB), bone marrow (BM) cells, involved in the homeostasis maintenance. Both CEC EPC thought to represent potential biomarkers several clinical conditions involving turnover/remodeling. Although different flow cytometry methods for characterization have been published so far, none them reached consistent conclusions, therefore consensus guidelines with respect...