A5086542748- Obstructive Sleep Apnea Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Photoreceptor and optogenetics research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Cardiovascular and Diving-Related Complications
- Optical Imaging and Spectroscopy Techniques
- EEG and Brain-Computer Interfaces
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Antioxidant Activity and Oxidative Stress
- Adenosine and Purinergic Signaling
- Sleep and related disorders
- Asthma and respiratory diseases
- Gut microbiota and health
- Vitamin C and Antioxidants Research
- Immune Response and Inflammation
University of Salento
2014-2025
University of Naples Federico II
2023
Ferrari (Italy)
2019
Ospedale Civile di Vittorio Veneto
2019
University of Campania "Luigi Vanvitelli"
2017
Istituto Nanoscienze
2015
Sapienza University of Rome
1998-1999
In the present study we used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model to analyze resveratrol neuroprotective effects. The MPTP-induced PD is characterized by chronic inflammation, oxidative stress and loss of dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc). We observed that treatment significantly reduced glial activation, decreasing levels IL-1β, IL-6 TNF-α, as well their respective receptors SNpc MPTP-treated...
Parkinson’s disease (PD) is a common neurodegenerative characterised by slow and progressive degeneration of dopaminergic neurons in the substantia nigra (SN). Despite intensive research, cause neuronal loss PD poorly understood. Inflammatory mechanisms have been implicated pathophysiology PD. In this study, conducted on an experimental 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model, we investigated expression interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6 their...
Krill oil (KO) is a dietary source of n-3 polyunsaturated fatty acids, mainly represented by eicosapentaenoic acid and docosahexaenoic bound to phospholipids. The supplementation high-fat diet with 2.5% KO efficiently prevented triglyceride cholesterol accumulation in liver treated rats. This effect was accompanied parallel reduction the plasma levels triglycerides glucose prevention insulin increase. investigation molecular mechanisms action fed animals revealed strong decrease activities...
Vitamin C (Vit C) is anutrient present in many foods, particularly citrus fruits, green vegetables, tomatoes, and potatoes. Vit studied for its applications the prevention management of different pathologies, including neurodegenerative diseases. Neuroinflammation a defense mechanism activated by stimulus or an insult that aimed at preservation brain promoting tissue repair removing cellular debris; however, persistent inflammatory responses are detrimental may lead to pathogenesis...
AbstractSystemic infections are often associated with neurodegenerative processes in many diseases of the central nervous system (CNS), including Parkinson's disease. Toll-like receptor (TLR)4 and CD14 act as receptors for lipopolysaccharide (LPS) released by gram-negative bacteria. In this contest, functions main LPS ligand TLR4 transmits signal into cell. paper, we investigated expression CD14, different anatomical areas CNS, an experimental model Parkinson's-like disease, represented...
OSA is a heterogeneous disease with variable physio-pathological and clinical manifestations, it associated numerous co-morbidities (1). It chronic inflammatory low degree of activity (2), in which the microbiome now widely considered to play role. In last few decades, research into has rapidly evolved become hot topic basic research, both pre-clinical clinical. Some recent studies have demonstrated that gut microbiota (GM), situated human gastrointestinal tract consisting bacteria, viruses,...
Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the inflammation, are pharmacological targets non-steroidal anti-inflammatory drugs, used treat pain inflammation. Since it was reported that COX-1 is major player mediating brain inflammatory response, aim this study evaluate effects highly...
α-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular accumulation of insoluble aggregates populated α-Synuclein (α-Syn) fibrils. In Parkinson’s disease (PD) and dementia with Lewy bodies, intraneuronal α-Syn referred to as bodies in somata neurites neuronal processes. multiple system atrophy (MSA) also found within mature oligodendrocytes (OLs) where they form Glial Cytoplasmic Inclusions (GCIs). However, origin GCIs remains enigmatic: (i) OLs do...
Human female reproductive system is closely dependent by hormonal stimulation. Anyway it now commonly stated that autonomic innervation regulates, along with stimulation, the uterine physiology. Cholinergic and adrenergic innervations have a critical role in mediating input to uterus, but other neurotransmitters neuropeptides exist influence physiology, as well. In present investigation, we analyzed distribution of large set neurotransmitters, focusing on adrenergic, noradredenergic,...
Among therapeutic approaches that have been investigated, targeting of receptors implicated in managing neuroinflammation has described. One such family comprises the formyl peptide (FPRs) whose ligands could play a role host defense. The murine FPR gene includes at least six members while humans there are only three. two most important Fpr1 and Fpr2. Fpr1encodes FPR1, which is considered orthologue human FPR. Resveratrol, non-flavonoid polyphenol rich red wine grapes, apart from its...
<b><i>Background/Aims:</i></b> Gastrointestinal damage (GD) is commonly associated with the inhibition of cyclooxygenase (COX)-1, one two known COXs, by traditional non-steroidal anti-inflammatory drugs. More recent evidences have proven that GD caused simultaneous COXs. This study was designed to evaluate effect selective COX-1 on gastric integrity. <b><i>Methods:</i></b> evaluated in male CD1 mice. Drugs were administered gavage at a dose 50...
The prolonged activation of microglia and excessive production pro-inflammatory cytokines can lead to chronic neuroinflammation, which is an important pathological feature Parkinson's disease (PD). We have previously reported the protective effect Vitamin C (Vit C) on a mouse model PD. However, its microglial functions in neuroinflammation remains be clarified. Glycogen synthase kinase 3β (GSK3β) serine/threonine having role driving inflammatory responses, making GSK3β inhibitors promising...