A5071172605- Neuroscience and Neural Engineering
- Planarian Biology and Electrostimulation
- Muscle activation and electromyography studies
- Pluripotent Stem Cells Research
- Neurological disorders and treatments
- Wireless Body Area Networks
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tissue Engineering and Regenerative Medicine
- Laser Applications in Dentistry and Medicine
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Sperm and Testicular Function
- Electromagnetic Fields and Biological Effects
- Microbial Inactivation Methods
- Autism Spectrum Disorder Research
- 3D Printing in Biomedical Research
- Reproductive Biology and Fertility
- Alzheimer's disease research and treatments
- Pain Management and Treatment
- Dysphagia Assessment and Management
- Vagus Nerve Stimulation Research
- Musculoskeletal pain and rehabilitation
Deutsches Historisches Institut Rom
2016-2025
Universidade de São Paulo
2025
University of Florence
2018-2022
University of Sassari
2022
Shanghai CASB Biotechnology (China)
2017
University of Salento
2015
The World Academy of Sciences
2009
Human adipose-derived stem cells (hASCs) have been recently proposed as a suitable tool for regenerative therapies their simple isolation procedure and high proliferative capability in culture. Although hASCs can be committed into different lineages vitro, the differentiation is low-yield often incomplete process. We developed novel nonenzymatic method device, named Lipogems, to obtain fat tissue derivative highly enriched pericytes/mesenchymal by mild mechanical forces from human...
Abstract Post-polio syndrome (PPS) brings new challenges for polio survivors, including muscle decline, pain, depression, and diminished quality of life. This study explored the potential REAC neuromodulatory treatments to ease improve mood, enhance life in PPS patients. 17 individuals with (average age 54.8) received three treatments: Neuro Postural Optimization, Psycho Physical Optimization-Cervico Brachial. Pain, anxiety, stress, were assessed before after using established scales....
Radiofrequency (RF) waves from Wi-Fi (wireless fidelity) technologies have become ubiquitous, with Internet access spreading into homes, and public areas. The human body harbors multipotent stem cells various grading of potentiality. Whether may be affected by RF energy remains unknown. We exposed mouse embryonic (ES) to a Radio Electric Asymmetric Conveyer (REAC), an innovative device delivering 2.4 GHz its conveyer electrodes immersed the culture medium. Cell responses were investigated...
Somatic cells can be directly reprogrammed to alternative differentiated fates without first becoming stem/progenitor cells. Nevertheless, the initial need for viral-mediated gene delivery renders this strategy unsafe in humans. Here, we provide evidence that exposure of human skin fibroblasts a Radio Electric Asymmetric Conveyer (REAC), an innovative device delivering radio electric conveyed fields at radiofrequency 2.4 GHz, afforded remarkable commitment toward cardiac, neuronal, and...
Abstract Decline in the gene expression of senescence repressor Bmi1 and telomerase, together with telomere shortening, underlay stem cells cultured for multiple passages. Here, we investigated whether impairment preventing mechanisms can be efficiently counteracted by exposure human adipose-derived to radio electric asymmetrically conveyed fields an innovative technology, named Radio Electric Asymmetric Conveyer (REAC). Due REAC exposure, number positively stained associated β-galactosidase...
Research for the use of physical means, in order to induce cell differentiation new therapeutic strategies, is one most interesting challenges field regenerative medicine, and then treatment neurodegenerative diseases, Parkinson's disease (PD) included. The aim this work verify effect radio electric asymmetric conveyer (REAC) technology on PC12 rat adrenal pheochromocytoma line, as they display metabolic features PD. cells were cultured with a REAC tissue optimization (TO-RGN) period ranging...
Abstract Hyaluronic acid (HA) plays a fundamental role in cell polarity and hydrodynamic processes, affording significant modulation of proliferation, migration, morphogenesis senescence, with deep implication the ability stem cells to execute their differentiating plans. The Radio Electric Asymmetric Conveyer (REAC) technology is aimed optimize ions fluxes at molecular level order mechanisms driving cellular asymmetry polarization. Here, we show that treatment 4-methylumbelliferone (4-MU),...
Background: This study evaluated the effectiveness of radio electric asymmetric conveyer (REAC) neurobiological optimization treatments on muscle strength (MS) in individuals with post-polio syndrome (PPS), a condition causing new weakness polio survivors. Traditional focus symptom management, whereas REAC technology uses symmetric conveyed fields to modulate neurotransmission and cellular function. Methods: open-label involved 17 PPS patients who maintained their existing medications. The...
An 88-year-old woman presented with a longstanding history of dizziness, tremors, and progressive mental physical decline, significantly impairing her mobility autonomy. Recently discharged from an ICU, the patient required extensive support for daily activities. Diagnostic evaluations, including EEG analysis, revealed irregular frequency peaks altered cortical activity, particularly in frontal prefrontal regions. The underwent cycle 18 sessions radio electric asymmetric conveyer (REAC)...
Human dental pulp stem cells (hDPSCs) have shown relevant potential for cell therapy in the orthopedic and odontoiatric fields. The optimization of their osteogenic is currently a major challenge. Vascular endothelial growth factor A (VEGF A) has been recently reported to act as conductor osteogenesis vitro vivo . Here, we attempted prime endogenous VEGF expression without need viral vector mediated gene transfer technologies. We show that hDPSCs exposure mixture hyaluronic, butyric,...
This case report describes the clinical progress of a 22-year-old male patient diagnosed with consolidating Hill-Sachs lesion, treated 18 sessions Tissue Optimization Reparative (TO-Rpr) protocol, specific to Radio Electric Asymmetric Conveyor (REAC) technology. At baseline, reported persistent pain numeric rating scale (NRS) score 7 out 10 and significant functional limitations shoulder (flexion 90°, abduction 70°, external rotation 20°), accompanied by bone marrow edema, tendinous...
Background: Beta-galactosidase is the most widely used biomarker for highlighting processes of cellular aging, including neurodegeneration. On this basis, we decided to test in vitro whether a set rescuing/reparative events previously observed by us subjects treated with radioelectric asymmetric conveyor (REAC) technology may also involve antagonism marker aging-related degenerative processes, as assessed reduction beta-galactosidase at level. Methods: Human adipose-derived stem cells were...
Abstract The aim of this randomized double-blind study was to evaluate in healthy adult subjects, with functional magnetic resonance imaging (fMRI), long lasting changes brain activation patterns following administration a single, 250 milliseconds pulse emitted radio-electric asymmetric conveyer (REAC) technology the Wi-Fi bands. REAC impulse not administered during scan, but after this, according protocol that has previously been demonstrated be effective improving motor control and...
Human breast adenocarcinoma is a form of cancer which has the tendency to metastasize other tissues, including bones, lungs, brain, and liver. Several chemotherapeutic drugs are used treat tumors. Their combination simultaneously target different mechanisms involved in cell replication. Radio electric asymmetric conveyer (REAC) technology an innovative technology, both vitro vivo, induce reprogramming counteract senescence processes. Within this context, we treated MCF-7 cells with...
Abstract The purpose of this study was the evaluation effectiveness in improvement psychic and symptomatic stress‐related disorders by means radio‐electric stimulation on some auricular reflex points with a device named asymmetric conveyer (REAC). This conducted 124 subjects psychological distress symptoms that were assessed Symptomatic Check List‐90 (SCL‐90) pre‐ post‐intervention. After randomization, two groups created: group treated effective REAC underwent same treatment disarmed (the...
Purpose: Behavioral and psychiatric symptoms of dementia (BPSD) are common in Alzheimer's disease (AD) disrupt the effective management AD patients. The present study explores use radio electric asymmetric brain stimulation (REAC) patients who have had a poor response to pharmacological treatment. Patients methods: Eight (five females three males; mean [±standard deviation] age at baseline: 69.9 ± 3.0 years) diagnosed with according DSM-IV-TR criteria (mean onset AD: 65.4 3.5 were...
The aim of this double-blind randomized study is to test the efficacy a radio electric stimulator device using an auricular reflex therapy protocol for stress-related symptoms. has been carried out on 200 subjects (138 females, 62 males) that voluntarily came our Institute declaring "feel stressed". participants were randomly allocated with computerized procedure: 150 treated therapeutic (REAC) and 50 inactivated, placebo REAC. Psychological stress was evaluated trough self-administered...
Purpose: Osteoarthritis (OA) is a degenerative disease characterized by progressive loss of articular cartilage extracellular matrix and due to functional impairments occurring in chondrocytes. In previous works, we highlighted that Regenerative Tissue Optimization (TO-RGN) treatment with radioelectric asymmetric conveyer (REAC) technology influenced the gene expression profiles controlling stem cell differentiation pluripotency human skin-derived fibroblasts vitro. Since interleukin-1 beta...
Fluctuating asymmetry (FA) is widely defined as the deviation from perfect bilateral symmetry and considered an epigenetic measure of environmental stress. Rinaldi Fontani hypothesized that FA morpho-functional changes originate adaptive motor behavior determined by functional alterations in cerebellum neural circuits, not caused a lesion, but induced They called this phenomenon dysmetria (FD). On premise, they developed radio electric asymmetric conveyer (REAC) technology, neuromodulation...
Simultaneous coexistence of anxiety with depressive disorders is probably one the major current problems in Medicine. The pharmacological approach for Panic Disorder and Major Depression includes "high-powered" benzodiazepines rapid, but transitory relief same symptoms especially antidepressant compounds. Recently physical-instrumental approaches have been tested treatment these complex diseases, like Cranial Electrotherapy Stimulation (CES), Trans-cranial Magnetic (TMS), Radio Electric...
Generalized anxiety disorder (GAD) is often presented with major depression (MD). GAD-MD can be a chronic and disabling condition, patients suffering from this respond poorly to psychopharmacological treatment experience side effects medication. Therefore, there high demand for effective nonpharmacological therapy patients. The current study explores the use of radioelectric asymmetric conveyer (REAC) device in GAD-MD.Participants were 24 diagnosed being treated at public psychiatric center....
Purpose: This study assessed changes in functional dysmetria (FD) and brain activation observable by magnetic resonance imaging (fMRI) during a leg flexion-extension motor task following stimulation with single radioelectric asymmetric conveyer (REAC) pulse, according to the precisely defined neuropostural optimization (NPO) protocol. Population methods: Ten healthy volunteers were using fMRI conducted simple before immediately after delivery of REAC-NPO pulse. The consisted movement legs...