A5069404918- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Aquaculture Nutrition and Growth
- Trace Elements in Health
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Physiological and biochemical adaptations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Prion Diseases and Protein Misfolding
- Cancer Cells and Metastasis
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Parkinson's Disease Mechanisms and Treatments
- HER2/EGFR in Cancer Research
- RFID technology advancements
- Enzyme function and inhibition
- Cellular Mechanics and Interactions
- Chronic Myeloid Leukemia Treatments
- Reproductive biology and impacts on aquatic species
- Neurological diseases and metabolism
- Gut microbiota and health
- Wireless Body Area Networks
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
Ospedale Vito Fazzi
2005-2025
University of Salento
2016-2025
La Trobe University
2023
Universitat Politècnica de València
2023
Istituto di Nanotecnologia
2021
Istituto Nanoscienze
2021
AOL (United States)
2017
Innovation Engineering (Italy)
1998-2015
Istituto Tumori Bari
2011
Casa Sollievo della Sofferenza
2011
Abstract —Because oleic acid is implicated in the antiatherogenic effects attributed to Mediterranean diet, we investigated whether this fatty can modulate endothelial activation, ie, concerted expression of gene products involved leukocyte recruitment and early atherogenesis. We incubated sodium oleate with human umbilical vein cells for 0 72 hours, followed by coincubation recombinant tumor necrosis factor, interleukin (IL)-1α, IL-1β, IL-4, Escherichia coli lipopolysaccharide (LPS), or...
Mitochondrial dysfunction is a key feature of cancer and frequently associated with increased aggressiveness metastatic potential. Recent evidence has brought to light metabolic rewiring that takes place during the epithelial-to-mesenchymal transition (EMT), process drives invasive capability malignant tumors, highlights mechanistic link between mitochondrial EMT been only partially investigated. In this study, we characterized function bioenergetic status cultured human breast cell lines,...
We report the molecular and functional characterisation of a novel peptide transporter from zebrafish, orthologue to mammalian avian PEPT1. Zebrafish PEPT1 is low‐affinity/high‐capacity system. However, in contrast higher vertebrate counterparts which maximal transport activity independent extracellular pH, zebrafish rates unexpectedly increase at alkaline pH. pept1 highly expressed proximal intestine since day 4 post‐fertilisation, thus preceding maturation gut, first feeding complete yolk...
Phytochemicals constitute a heterogeneous group of substances with an evident role in human health. Their properties on cancer initiation, promotion and progression are well documented. Particular attention is now devoted to better understand the molecular basis their anticancer action. In present work, we studied effect resveratrol ovarian cell line OVCAR-3 by proteomic approach. Our findings demonstrate that down-regulates protein cyclin D1 and, concentration dependent manner,...
The new goal of anticancer agent research is the screening natural origin drugs with lower systemic adverse effects than synthetic compounds. Here, we focus on curcumin, an important polyphenolic pigment classically used as spice in Indian cuisine. molecule has high pleiotropic activities including strong antioxidant and anti‐inflammatory properties. However, its clinical potential limited due low solubility bioavailability. We have developed a layer by functionalization Fe 3 O 4...
β-catenin plays an important role as regulatory hub in several cellular processes including cell adhesion, metabolism, and epithelial mesenchymal transition. This is mainly achieved by its dual structural component of cadherin-based adherens junctions, a key nuclear effector the Wnt pathway. For this role, different classes proteins are differentially regulated via dependent mechanisms. Here, we applied liquid chromatography-mass spectrometry (LC-MS/MS) approach to identify modulated after...
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia associated with alterations in carbohydrate, lipid, and protein metabolism. The prognosis of T2DM patients highly dependent on the development complications, therefore identification biomarkers progression, minimally invasive techniques, huge need. In present study, we applied 1H-Nuclear Magnetic Resonance (1H-NMR)-based metabolomic approach coupled multivariate data analysis to identify serum...
To determine the in vivo and vitro antiangiogenic power of lenalidomide, a "lead compound" IMiD immunomodulatory drugs bone marrow (BM) endothelial cells (EC) patients with multiple myeloma (MM) active phase (MMEC).The effect was studied using chorioallantoic membrane (CAM) assay. Functional studies (angiogenesis, "wound" healing chemotaxis, cell viability, adhesion, apoptosis) were conducted both primary MMECs ECs monoclonal gammopathies (MGUS) undetermined significance (MGEC) or healthy...
The aim of this study was to investigate the angiogenic role hepatocyte growth factor (HGF)/cMET pathway and its inhibition in bone marrow endothelial cells (EC) from patients with multiple myeloma versus monoclonal gammopathy undetermined significance (MGUS) or benign anemia (control group).The HGF/cMET evaluated ECs (multiple ECs) at diagnosis, relapse after bortezomib- lenalidomide-based therapies, on refractory phase these drugs; MGUS (MGECs); those control group. effects a selective...
The growing understanding of the molecular mechanisms underlying epithelial-to-mesenchymal transition (EMT) may represent a potential source clinical markers. Despite EMT drivers have not yet emerged as candidate markers in setting, their association with established improve specificity and sensitivity. Mass spectrometry-based platforms allow analyzing multiple samples for expression markers, help to diagnose diseases or monitor treatment efficiently. This review highlights proteomic...
Dietary phytochemicals found in vegetables and fruits consist of a wide variety biologically active compounds with anti-carcinogenic activity. The aim this study was to evaluate the antigrowth activity carnosol, dietary diterpene, as single agent or combination other chemotherapeutic drugs against panel tumor cell lines. Carnosol decreased viability human breast, ovarian, intestinal lines, inhibited cancer adhesion on fibronectin growth cells suspension. also EGF-induced epithelial...