A5036497463- Estrogen and related hormone effects
- Computational Drug Discovery Methods
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Bioinformatics and Genomic Networks
- Cancer Treatment and Pharmacology
- Bladder and Urothelial Cancer Treatments
- Telomeres, Telomerase, and Senescence
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Breast Lesions and Carcinomas
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Global Cancer Incidence and Screening
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Università degli Studi di Enna Kore
2024-2025
Second Xiangya Hospital of Central South University
2023
Peking University
2023
Peking University First Hospital
2023
Central South University
2023
Second Military Medical University
2021
Changhai Hospital
2021
Creative Commons
2020
Breast cancer is a leading cause of mortality worldwide. Pharmacological inhibitors cyclin-dependent kinases (CDK) 4 and 6 (CDK4/6i) inhibit breast growth by inducing senescent-like state. However, the long-term treatment efficacy remains limited development drug resistance, so clearance cells may extend durability treatment. we show here that while CDK4/6i-treated exhibit various senescence-associated phenotypes, they remain insensitive to common senolytic compounds. By searching for novel...
Prostate cancer (PCa) patients are risk-stratified on the basis of clinical stage and PSA level at diagnosis Gleason Score (GS) in prostate biopsy. However, these parameters not completely accurate discriminating between high- low-risk disease, creating a need for reliable marker to determine aggressiveness. Prostate-specific membrane antigen (PSMA) appears fulfill this need. We analyzed 79 biopsies 28 prostatectomies assess whether PSMA expression detected by immunohistochemistry is related...
Resistant tumours are thought to arise from the action of Darwinian selection on genetically heterogenous cancer cell populations. However, simple clonal is inadequate describe late relapses often characterising luminal breast cancers treated with endocrine therapy (ET), suggesting a more complex interplay between genetic and non-genetic factors. Here, we dissect contributions diversity transcriptional plasticity during early phases ET at single-cell resolution. Using RNA-sequencing imaging...
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia associated with alterations in carbohydrate, lipid, and protein metabolism. The prognosis of T2DM patients highly dependent on the development complications, therefore identification biomarkers progression, minimally invasive techniques, huge need. In present study, we applied 1H-Nuclear Magnetic Resonance (1H-NMR)-based metabolomic approach coupled multivariate data analysis to identify serum...
Tumors are complex and heterogeneous diseases characterized by an intricate milieu dynamically in connection with surrounding distant tissues. In the last decades, great efforts have been made to develop novel preclinical models able recapitulate original features of tumors. However, development vitro functional realistic tumor organ is still utopic represents one major challenges reproduce architecture ecosystem. A strategy decrypt whole picture predict its behavior could be started from...
Background: Cyclin-dependent kinase 4 and 6 (CDK4 CDK6) inhibitors have changed the therapeutic management of hormone receptor-positive (HR+) metastatic breast cancer (mBC) by targeting cell cycle machinery overcoming endocrine resistance. However, a large number patients present disease progression due to cells resisting CDK4/6 inhibitors. Our research considers which clinicopathological characteristics could be useful in identifying who might respond analyzing retrospective case series...
miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Here, we show that high levels are associated with unfavorable prognostic factors two independent cancer cohorts (CSS cohort, n=283; and TCGA-BC dataset, n=1095). Consistently, results as differentially expressed the subgroups identified by surrogate molecular classification CSS-cohort PAM50 classifier TNBC HER2-amplified tumors carrying highest levels. Since...
While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In attempt to clarify this, we profiled members expression in large cohort cases with long follow-up (H-CSS cohort) and TCGA-BRCA cohort. Overall, was found upregulated tumors respect normal tissues while downregulated more aggressive subtypes (i.e. Luminal B, HER2 triple negative), consistently their function repressors...
ABSTRACT COVID‐19 remains a significant global health problem with uncertain long‐term consequences for convalescents. We investigated the relationships between anti‐N protein antibody levels, severe acute respiratory syndrome (SARS)‐CoV‐2‐associated TCR repertoire parameters, HLA type and epidemiological information from three cohorts of 524 SARS‐CoV‐2‐infected subjects subgrouped in phase, seronegative seropositive convalescents Emilia Romagna region. Epidemiological index were associated...